Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Open accessAbstract
A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase their motility, exit the spleen en masse, accumulate in injured tissue, and participate in wound healing. These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These monocytes derive from the peripheral blood and from pools in the bone marrow and possibly in the spleen.
“These monocytes derive from the peripheral blood and from pools in the BM and possibly in the spleen (Swirski et al., 2009).”
From Iron in infection and immunity (2020) · cites this paper as Swirski et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106 · see citing works
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,365 · see citing works
Self-citationNahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Self-citationStructure and function of the spleen
Mebius, R. E., & Kraal, G. (2005) · Nature reviews. Immunology · doi:10.1038/nri1669 · Cited by 2,245 · see citing works
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973 · see citing works
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712 · see citing works
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658 · see citing works
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,647 · see citing works
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564 · see citing works
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
Immune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313 · see citing works
Świrski, F. K., Libby, P., Aikawa, E. R., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,258 · see citing works
Self-citationTsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152 · see citing works
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124 · see citing works
Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii
Dunay, I. R., DaMatta, R. A., Fux, B., Presti, R. M., Greco, S., Colonna, M., & Sibley, L. D. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.019 · Cited by 433 · see citing works
AbdAlla, S., Lother, H., Langer, A., el Faramawy, Y., & Quitterer, U. (2004) · Cell · doi:10.1016/j.cell.2004.10.006 · Cited by 204 · see citing works
Nahrendorf, M., Sosnovik, D. E., Waterman, P. R., Świrski, F. K., Pande, A. N., Aikawa, E. R., Figueiredo, J., Pittet, M. J., & Weissleder, R. (2007) · Circulation Research · doi:10.1161/01.res.0000265064.46075.31 · Cited by 158 · see citing works
Self-citationAngiotensin II Induces Migration and Pyk2/Paxillin Phosphorylation of Human Monocytes
Kintscher, U., Wakino, S., Kim, S., Fleck, E., Hsueh, W. A., & Law, R. E. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.587 · Cited by 105 · see citing works
The Actions of Drugs on the Smooth Muscle of the Capsule and Blood Vessels of the Spleen
Davies, B. N., & Withrington, P. G. (1973) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06615-3 · Cited by 105 · see citing works
Neuroendocrine changes in acute myocardial infarction
McAlpine, H. M., & Cobbe, S. M. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90206-9 · Cited by 76 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015 · see citing works
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067 · see citing works
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Cholesterol, inflammation and innate immunity.
Tall, A. R., & Yvan-Charvet, L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3793 · Cited by 1,479 · see citing works
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271 · see citing works
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3258 · Cited by 1,041 · see citing works
Self-citationPhagocyte partnership during the onset and resolution of inflammation
Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works
Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · see citing works
Monocytes in atherosclerosis: subsets and functions
Woollard, K. J., & Geissmann, F. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.228 · Cited by 890 · see citing works
Therapeutic siRNA silencing in inflammatory monocytes in mice
Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T. I., Donahoe, J. S., Courties, G., Lee, K. M., Kim, J. I., Markmann, J. F., Marinelli, B., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1989 · Cited by 839 · see citing works
Self-citationThe role of myeloid cells in cancer therapies
Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788 · see citing works
Self-citationImaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works
Bajpai, G., Bredemeyer, A., Li, W., Zaitsev, K., Koenig, A. L., Lokshina, I., Mohan, J., Ivey, B., Hsiao, H.-M., Weinheimer, C., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314028 · Cited by 751 · see citing works
Wen, Y., Lambrecht, J., Ju, C., & Tacke, F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00558-8 · Cited by 695 · see citing works
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673 · see citing works
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Guidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526 · see citing works
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514 · see citing works
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62636 · Cited by 481 · see citing works
Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.185 · Cited by 477 · see citing works
Pittet, M. J., & Weissleder, R. (2011) · Cell · doi:10.1016/j.cell.2011.11.004 · Cited by 466 · see citing works
Self-citationSleep modulates haematopoiesis and protects against atherosclerosis
McAlpine, C. S., Kiss, M. G., Rattik, S., He, S., Vassalli, A., Valet, C., Anzai, A., Chan, C. T., Mindur, J. E., Kahles, F., et al. (2019) · Nature · doi:10.1038/s41586-019-0948-2 · Cited by 447 · see citing works
Self-citationOn-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Theurl, I., Hilgendorf, I., Nairz, M., Tymoszuk, P., Haschka, D., Asshoff, M., He, S., Gerhardt, L. M. S., Holderried, T. A. W., Seifert, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4146 · Cited by 412 · see citing works
Self-citationSeidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-30 · Cited by 390 · see citing works
Ma, Y., Mouton, A. J., & Lindsey, M. L. (2018) · Translational Research · doi:10.1016/j.trsl.2017.10.001 · Cited by 405 · see citing works
Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
Marbach, D., Lamparter, D., Quon, G., Kellis, M., Kutalik, Z., & Bergmann, S. (2016) · Nature Methods · doi:10.1038/nmeth.3799 · Cited by 326 · see citing works
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378 · see citing works
Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
Getts, D. R., Terry, R. L., Getts, M. T., Deffrasnes, C., Müller, M., van Vreden, C., Ashhurst, T. M., Chami, B., McCarthy, D., Wu, H., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007563 · Cited by 378 · see citing works
Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design
Ogle, M. E., Segar, C. E., Sridhar, S., & Botchwey, E. A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216650293 · Cited by 378 · see citing works
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Faraco, G., Sugiyama, Y., Lane, D., Garcia-Bonilla, L., Chang, H., Santisteban, M. M., Racchumi, G., Murphy, M., Van Rooijen, N., Anrather, J., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86950 · Cited by 350 · see citing works
A novel Ly6C/Ly6G‐based strategy to analyze the mouse splenic myeloid compartment
Rose, S., Misharin, A., & Perlman, H. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22012 · Cited by 347 · see citing works
Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329 · see citing works
Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W., & Rosenthal, N. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036814 · Cited by 318 · see citing works
Identification of an atypical monocyte and committed progenitor involved in fibrosis
Satoh, T., Nakagawa, K., Sugihara, F., Kuwahara, R., Ashihara, M., Yamane, F., Minowa, Y., Fukushima, K., Ebina, I., Yoshioka, Y., et al. (2017) · Nature · doi:10.1038/nature20611 · Cited by 302 · see citing works
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis
Revelo, X. S., Parthiban, P., Chen, C., Barrow, F., Fredrickson, G., Wang, H., Yücel, D., Herman, A., & van Berlo, J. H. (2021) · Circulation Research · doi:10.1161/circresaha.121.319737 · Cited by 298 · see citing works
Wohleb, E. S., McKim, D. B., Shea, D. T., Powell, N. D., Tarr, A. J., Sheridan, J. F., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.029 · Cited by 300 · see citing works
Rahbari, N. N., Kedrin, D., Incio, J., Liu, H., Ho, W. W., Nia, H. T., Edrich, C. M., Jung, K., Daubriac, J., Chen, I., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf5219 · Cited by 258 · see citing works
Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation
Kurotaki, D., Osato, N., Nishiyama, A., Yamamoto, M., Ban, T., Sato, H., Nakabayashi, J., Umehara, M., Miyake, N., Matsumoto, N., et al. (2013) · Blood · doi:10.1182/blood-2012-06-437863 · Cited by 252 · see citing works
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251 · see citing works
Myeloid suppressor cells in cancer and autoimmunity
Sica, A., & Massarotti, M. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.07.010 · Cited by 201 · see citing works
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1
Dutta, P., Hoyer, F. F., Grigoryeva, L. S., Sager, H. B., Leuschner, F., Courties, G., Borodovsky, A., Novobrantseva, T., Ruda, V. M., Fitzgerald, K., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141642 · Cited by 180 · see citing works
Self-citationReader, B. F., Jarrett, B. L., McKim, D. B., Wohleb, E. S., Godbout, J. P., & Sheridan, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.001 · Cited by 179 · see citing works
“The idea that the spleen serves as an alternative source of monocyte trafficking is seen in several studies involving inflammatory challenges including myocardial infarction (Swirski et al., 2009) and stroke (Seifert et al., 2012).”
BackgroundGata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis
Deniset, J. F., Belke, D., Lee, W.-Y., Jorch, S. K., Deppermann, C., Hassanabad, A. F., Turnbull, J. D., Teng, G., Rozich, I., Hudspeth, K., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.010 · Cited by 178 · see citing works
Macrophages in the Aging Liver and Age-Related Liver Disease
Stahl, E. C., Haschak, M. J., Popovic, B., & Brown, B. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02795 · Cited by 171 · see citing works
Rudmann, D. G., Alston, J. T., Hanson, J. C., & Heidel, S. (2013) · Toxicologic Pathology · doi:10.1177/0192623312474726 · Cited by 170 · see citing works
Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses
Jetten, N., Roumans, N., Gijbels, M. J., Romano, A., Post, M. J., de Winther, M. P. J., van der Hulst, R. R. W. J., & Xanthoulea, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102994 · Cited by 162 · see citing works
Chong, S. Z., Evrard, M., Devi, S., Chen, J., Lim, J. Y., See, P., Zhang, Y., Adrover, J. M., Lee, B., Tan, L., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160800 · Cited by 142 · see citing works
Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat
McKim, D. B., Patterson, J. M., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Godbout, J. P., & Sheridan, J. F. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.010 · Cited by 137 · see citing works
The neuroimmunology of social-stress-induced sensitization
Biltz, R. G., Sawicki, C. M., Sheridan, J. F., & Godbout, J. P. (2022) · Nature Immunology · doi:10.1038/s41590-022-01321-z · Cited by 132 · see citing works
Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo
Lewis, D. R., Petersen, L. K., York, A. W., Zablocki, K. R., Joseph, L. B., Kholodovych, V., Prud’homme, R. K., Uhrich, K. E., & Moghe, P. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424594112 · Cited by 111 · see citing works
Leuschner, F., & Nahrendorf, M. (2011) · Circulation Research · doi:10.1161/circresaha.110.232678 · Cited by 110 · see citing works
Self-citationNahrendorf, M., & Swirski, F. K. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv453 · Cited by 95 · see citing works
Self-citationA role for spleen monocytes in post-ischemic brain inflammation and injury
Bao, Y., Kim, E., Bhosle, S., Mehta, H., & Cho, S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-92 · Cited by 94 · see citing works
Paré, A., Mailhot, B., Lévesque, S. A., Juzwik, C., Ignatius Arokia Doss, P. M., Lécuyer, M.-A., Prat, A., Rangachari, M., Fournier, A., & Lacroix, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714948115 · Cited by 94 · see citing works
Protective features of peripheral monocytes/macrophages in stroke
Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88 · see citing works
Monocyte and macrophage biology: an overview
Rees, A. J. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.002 · Cited by 84 · see citing works
Harms, R., Morsey, B., Boyer, C. W., Fox, H. S., & Sarvetnick, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049897 · Cited by 81 · see citing works
Lessard, A.-J., LeBel, M., Egarnes, B., Préfontaine, P., Thériault, P., Droit, A., Brunet, A., Rivest, S., & Gosselin, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.009 · Cited by 70 · see citing works
Bedolla, A. M., McKinsey, G. L., Ware, K., Santander, N., Arnold, T. D., & Luo, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113660 · Cited by 53 · see citing works
“The spleen is a particularly important site for the storage and rapid deployment of monocytes in the setting of development and inflammation 25-27 and can be used as a surrogate for circulating monocytes with recombination activity.”
Brown, D. E., Libby, S. J., Moreland, S. M., McCoy, M. W., Brabb, T., Stepanek, A., Fang, F. C., & Detweiler, C. S. (2013) · Veterinary Pathology · doi:10.1177/0300985813478213 · Cited by 48 · see citing works
Reboll, M. R., Korf-Klingebiel, M., Klede, S., Polten, F., Brinkmann, E., Reimann, I., Schönfeld, H.-J., Bobadilla, M., Faix, J., Kensah, G., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.029980 · Cited by 48 · see citing works
Nonmyogenic Cells in Skeletal Muscle Regeneration
Paylor, B., Natarajan, A., Zhang, R.-H., & Rossi, F. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00006-1 · Cited by 49 · see citing works
Terry, R. L., Deffrasnes, C., Getts, D. R., Minten, C., van Vreden, C., Ashhurst, T. M., Getts, M. T., Xie, R. D. V., Campbell, I. L., & King, N. J. C. (2015) · Journal of Innate Immunity · doi:10.1159/000365972 · Cited by 40 · see citing works
Monteiro, S., Pinho, A. G., Macieira, M., Serre-Miranda, C., Cibrão, J. R., Lima, R., Soares-Cunha, C., Vasconcelos, N. L., Lentilhas-Graça, J., Duarte-Silva, S., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01945-8 · Cited by 36 · see citing works
Ergen, C., Niemietz, P. M., Heymann, F., Baues, M., Gremse, F., Pola, R., van Bloois, L., Storm, G., Kiessling, F., Trautwein, C., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.025 · Cited by 27 · see citing works
Imaging macrophage development and fate in atherosclerosis and myocardial infarction
Swirski, F. K., & Nahrendorf, M. (2013) · Immunology & Cell Biology · doi:10.1038/icb.2012.72 · Cited by 23 · see citing works
Self-citationMacrophage heterogeneity in liver fibrosis
Wang, W., Li, S., Liu, Y., Ding, X., Yang, Y., Chen, S., Cao, J., Tacke, F., Dong, W., & Lan, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639455 · Cited by 8 · see citing works
Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages
Aquino, J. B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792423 · Cited by 1 · see citing works
- Authors
- Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., Aikawa, E., Mempel, T. R., Libby, P., Weissleder, R., & Pittet, M. J.
- Affiliations
- Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Nahrendorf, Matthias
- Weissleder, Ralph
- ORCID
- Venue
- Science
- Published
- 2009-07-31
- Volume
- 325
- Issue
- 5940
- Pages
- 612-616
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2803111
- OpenAlex
- W2003870922
- Cited by
- 2,221
- References
- 27
- Citations by year
- 2026: 72 · 2025: 92 · 2024: 130 · 2023: 125 · 2022: 134 · 2021: 147 · 2020: 148 · 2019: 137 · 2018: 151 · 2017: 167 · 2016: 158 · 2015: 131 · 2014: 169 · 2013: 135 · 2012: 129
- FWCI
- 46.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion, other-oa)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Public Health Service (P01 A154904)
- National Heart, Lung, and Blood Institute (U01HL080731, R01HL095629, R00HL094533, R01HL096576, R01HL095612)
- National Cancer Institute (P50-CA-86355, P50CA086355, R24 CA69246, U54CA126515)
- National Institute of Allergy and Infectious Diseases (P01AI054904)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- splenic monocytes, monocyte mobilization, myocardial ischemic injury, wound healing, inflammation, monocyte differentiation, dendritic cells, macrophages
- MeSH terms
- Angiotensin II, Animals, Antigens, Ly, Bone Marrow Cells, Cell Differentiation, Cell Movement, Female, Inflammation, Mice, Inbred C57BL, Monocytes, Myocardial Infarction, Myocardium, Receptors, Angiotensin, Spleen, Splenectomy, Rats, Wistar, Cell Size, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
