The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
Open accessAbstract
Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac–derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown. By performing BrdU labeling and parabiosis experiments in adult mice, we found that circulating monocytes contributed minimally to the steady-state AMF pool. Mature AMFs were undetectable before birth and only fully colonized the alveolar space by 3 d after birth. Before birth, F4/80hiCD11blo primitive macrophages and Ly6ChiCD11bhi fetal monocytes sequentially colonized the developing lung around E12.5 and E16.5, respectively. The first signs of AMF differentiation appeared around the saccular stage of lung development (E18.5). Adoptive transfer identified fetal monocytes, and not primitive macrophages, as the main precursors of AMFs. Fetal monocytes transferred to the lung of neonatal mice acquired an AMF phenotype via defined developmental stages over the course of one week, and persisted for at least three months. Early AMF commitment from fetal monocytes was absent in GM-CSF–deficient mice, whereas short-term perinatal intrapulmonary GM-CSF therapy rescued AMF development for weeks, although the resulting AMFs displayed an immature phenotype. This demonstrates that tissue-resident macrophages can also develop from fetal monocytes that adopt a stable phenotype shortly after birth in response to instructive cytokines, and then self-maintain throughout life.
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Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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Self-citationA Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
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InfluentialInfiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
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Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung
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Cited by
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Self-citationMonocytes and macrophages: developmental pathways and tissue homeostasis
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Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585
Metadata
- Authors
- Guilliams, M., De Kleer, I., Henri, S., Post, S., Vanhoutte, L., De Prijck, S., Deswarte, K., Malissen, B., Hammad, H., & Lambrecht, B. N.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2013-09-16
- Volume
- 210
- Issue
- 10
- Pages
- 1977-1992
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2100646399
- Cited by
- 1,276
- References
- 13
- FWCI
- 32.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guilliams, M., De Kleer, I., Henri, S., Post, S., Vanhoutte, L., De Prijck, S., Deswarte, K., Malissen, B., Hammad, H., & Lambrecht, B. N. (2013). Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20131199
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