The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase
Open accessAbstract
Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades. Whether concurrent changes in the cellular metabolism that occur upon TLR activation influence the quality of the transcriptional responses remains unknown. Here, we investigated how macrophages adopt their metabolism early after activation to regulate TLR-inducible gene induction. Shortly after TLR4 activation, macrophages increased glycolysis and tricarboxylic acid (TCA) cycle volume. Metabolic tracing studies revealed that TLR signaling redirected metabolic fluxes to generate acetyl-Coenzyme A (CoA) from glucose resulting in augmented histone acetylation. Signaling through the adaptor proteins MyD88 and TRIF resulted in activation of ATP-citrate lyase, which in turn facilitated the induction of distinct LPS-inducible gene sets. We postulate that metabolic licensing of histone acetylation provides another layer of control that serves to fine-tune transcriptional responses downstream of TLR activation. Our work highlights the potential of targeting the metabolic-epigenetic axis in inflammatory settings.
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Metadata
- Authors
- Lauterbach, M. A., Hanke, J. E., Serefidou, M., Mangan, M. S. J., Kolbe, C.-C., Hess, T., Rothe, M., Kaiser, R., Hoss, F., Gehlen, J., Engels, G., Kreutzenbeck, M., Schmidt, S. V., Christ, A., Imhof, A., Hiller, K., & Latz, E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 51
- Issue
- 6
- Pages
- 997-1011.e7
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2994673696
- Cited by
- 434
- References
- 63
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lauterbach, M. A., Hanke, J. E., Serefidou, M., Mangan, M. S. J., Kolbe, C.-C., Hess, T., Rothe, M., Kaiser, R., Hoss, F., Gehlen, J., Engels, G., Kreutzenbeck, M., Schmidt, S. V., Christ, A., Imhof, A., Hiller, K., & Latz, E. (2019). Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. https://doi.org/10.1016/j.immuni.2019.11.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
