The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
Principles of regulatory T cell function
Open accessAbstract
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of Treg cells as principal guardians of the immune system can be attributed to their ability to restrain all currently recognized major types of inflammatory responses through modulating the activity of a wide range of cells of the innate and adaptive immune system. This broad purview over immunity and inflammation is afforded by the multiple modes of action Treg cells exert upon their diverse molecular and cellular targets. Beyond the suppression of autoimmunity for which they were originally recognized, Treg cells have been implicated in tissue maintenance, repair, and regeneration under physiologic and pathologic conditions. Herein, we discuss the current and emerging understanding of Treg cell effector mechanisms in the context of the basic properties of Treg cells that endow them with such functional versatility.
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Cites
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Self-citationInduction of Colonic Regulatory T Cells by Indigenous Clostridium Species
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Cited by
CAR-Treg cell therapies and their future potential in treating ocular autoimmune conditions
Abraham, A. R., Maghsoudlou, P., Copland, D. A., Nicholson, L. B., & Dick, A. D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1184937 · Cited by 20
“Alternative approaches have included the use of engineered receptors to redirect the specificity of a starting population of Tregs, or the conversion of antigen specific effector T-cells into Tregs through enforced FOXP3 expression (23).”
BackgroundInfluentialLee, S. E., Jo, M. G., Park, S. W., Kim, H. J., Yun, S. P., & Kim, J.-W. (2026) · Animal Cells and Systems · doi:10.1080/19768354.2026.2630463 · Cited by 2
“Therefore, blockade of integrin αvβ8 decreased active TGF-β levels in the livers of mice and attenuated fibrosis, underscoring the role of the ATF4–integrin αvβ8 axis in Treg-mediated fibrogenesis (Brown and Marshall 2019; Wang et al. 2025).”
Influential
Metadata
- Authors
- Dikiy, S., & Rudensky, A. Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 56
- Issue
- 2
- Pages
- 240-255
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4320730824
- Cited by
- 445
- References
- 222
- FWCI
- 39.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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