The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
Open accessAbstract
Mitochondrial dysfunction is a hallmark of cellular senescence. Here, we investigated whether senescent cells release mitochondrial (mt)DNA into the extracellular space and its impact on innate immunity. We found that both primary senescent cells and tumor cells undergoing therapy-induced senescence actively released mtDNA into the extracellular environment. mtDNA released by senescent cells was packaged within extracellular vesicles and selectively transferred to polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in the tumor microenvironment. Upon uptake, extracellular mtDNA enhanced the immunosuppressive activity of PMN-MDSCs via cGAS-STING-NF-κB signaling, thereby promoting tumor progression. While STING activation directly induced NF-κB signaling, it also activated PKR-like endoplasmic reticulum kinase (PERK), which further amplified NF-κB activity, in PMN-MDSCs. mtDNA release from senescent cells was mediated by voltage-dependent anion channels (VDACs), and pharmacological inhibition of VDAC reduced extracellular mtDNA levels, reversed PMN-MDSC-driven immunosuppression, and enhanced chemotherapy efficacy in prostate cancer mouse models. These findings suggest that targeting mtDNA release could reprogram the immunosuppressive tumor microenvironment, improving therapeutic outcomes for chemotherapy-treated patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It can recognize mtDNA released during liver injury, leading to its activation and the triggering of inflammation with the production of type I interferons (IFNs) and proinflammatory cytokines, which exacerbates liver inflammation and hepatocyte damage (20–22).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [20]
Citations
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751
Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993
Mitochondrial DNA stress primes the antiviral innate immune response
West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Veglia, F., Sanseviero, E., & Gabrilovich, D. I. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00490-y · Cited by 1,940
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–175 of 175
Olou, A. A., Tom, W. A., & Fernando, M. R. (2026) · iScience · doi:10.1016/j.isci.2026.115453
VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC
Shi, J., Liu, C., Wang, X., Li, C., Zhang, Z. H., Yan, M., Guo, H., & Zhang, J. Y. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70276
Wu, X., Li, Y., Ye, Z., & Li, J. (2026) · The FASEB Journal · doi:10.1096/fj.202600624r
Mitochondrial metabolism as a pharmacological target for cancer therapeutics
Yu, Y., Ding, W., Liu, S., Glorieux, C., Liu, P., & Huang, P. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100137
Li, J., Du, G., Liu, Q., Lv, J., Qi, W., Liu, H., Qi, H., Qiu, W., & Wang, S. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108241
Systemic Propagation of STING Signalling via Generation of Large Extracellular Vesicles
Lee, J., Vernon, A., Park, H. J., & Kwon, Y. V. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70289 · Cited by 1
Negative regulators antagonizing antitumor innate immune pathways in lung cancer immune evasion
Yang, F., Liu, R., Liu, L., Zhang, A., & Li, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1842558
Self-citationClosantel, an FDA-approved veterinary drug, suppresses PEDV replication via targeting main protease
Zhang, L., Wang, Z., Xu, F., Zhao, Y., Gao, C., Xu, Y., Zhang, R., Shu, Y., Xing, P., & Lin, Y. (2026) · Virology · doi:10.1016/j.virol.2026.110942
The role of macrophage senescence in cardiovascular diseases
Sun, Y., 常英新, Lin, H., Fan, G., Li, L., & Ma, C. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112577 · Cited by 1
ACOX2 at the crossroads of peroxisomal metabolism, DNA damage sensing, and anticancer immunity
Zheng, M., Zhao, B., Chen, X., & Zhao, Y. (2026) · Gene · doi:10.1016/j.gene.2026.150232 · Cited by 1
Misplaced nucleic acids as a trigger of coagul-aging
Giuliani, A., Fantone, S., Sbriscia, M., Cardelli, M., Olivieri, F., Rippo, M. R., & Sabbatinelli, J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103190
Extracellular Vesicle-Based Strategies for the Prevention of Chemotherapy-Induced Cardiotoxicity
Zhaoqin, S., Qiu, J., Yu, W., Chen, R., & Jiang, Y. (2026) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s597871 · Cited by 1
Yang, W., Guo, H., Cao, X., Lai, Y., Sun, J., He, Y., Li, D., Sun, Z., & Zeng, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-9626058/v1
Li, Y., Xu, S., Wang, G., Song, Z., Zhang, S., Dai, X., & Wang, S. (2026) · ACS Nano · doi:10.1021/acsnano.6c06383
Self-citationYang, J., Li, Y., Kumar, S. V., Saba, N. F., Shay, C., & Teng, Y. (2026) · Biomarker Research · doi:10.1186/s40364-026-00955-7
Self-citationXia, G., Wang, C., Peng, L., Xing, W., Wang, L., & Zheng, Z. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103373
Extracellular vesicles in solid tumors: from tumor ecology to engineered therapeutics
Cai, W., Chen, Y., Dai, S., Cheng, C., & Chen, L. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02705-7
Hai, L., Wang, J., Liu, D., Yun, K., Ma, K., Peng, Y., Xu, M., Ma, X., Gao, S., Wang, Q., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.043
Liang, S., Wu, S., Yin, J., Gao, T., Liu, M., Gao, Y., Luo, F., Wu, D. W., Yu, S., Zhao, L., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158513
Yan, L., Liu, S. R., Wu, K., Gao, M., Yan, D., Tian, M., Xiao, J., Yang, Y., & Qin, B. (2026) · Cell Biology International · doi:10.1002/cbin.70185
Bao-Sheng, W. A. N. G., & Ben, Z. H. O. U. (2026) · Shengming kexue · doi:10.3724/cbls.2026103
Jin, H., Mei, Y., Gao, X., Zhang, W., Li, H., Chen, Y., & Sun, B. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104297
Qu, H., Zhou, P., Yu, J., Deng, K., Zhou, Y., Wang, N., Chen, Y., & Xia, J. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1016269
The mitochondrial DNA signal in rheumatoid arthritis: From metabolic victim to inflammatory driver
Zhang, R., Song, Z., Xin, Q., Xing, W., Zhang, W., & Yang, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154304 · Cited by 1
Inorganic nanomaterials activate the cGAS-STING pathway for tumor treatment
Chen, Y., Li, Q., Zhou, J., & Cheng, L. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109088
Liu, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1872804
Genetic and epigenetic modifiers of metastasis: Context matters
Welch, D. R., Swancutt, K. L., Walsh, R. M., & Fisette, G. (2026) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583526100201
Senescence-Associated Exosomes and Intercellular Communication in Cancer
Arjmand, B., Shahrahmani, F., Moradi, S., Alavi-Moghadam, S., Rezaei–Tavirani, M., Janbabaei, G., & Rad, S. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-026-00621-2
Gong, C., Li, S., Huang, Y., Luo, E., Tan, Z., Li, H., Kong, Y., & Ding, M. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118333
Prostate cancer: evading immunity, inspiring therapy
Calì, B., Brina, D., Moscarda, V., Kohl, A., Cetti, F., Bressan, S., & Alimonti, A. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.07.006
Self-citationCui, D., Zhang, H., Nan, Y., Xu, D., Cai, C., Hui, Y., Peng, X., Wang, Y., Ma, W., & Tang, Y. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108393
Mitochondrial transfer: a new perspective on tumor-microenvironment crosstalk driving metastasis
Duan, Y., Li, A., Hu, X., Xiong, Z., Shi, J., & Wang, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1922061
Su, P., Wanyu, L., Chao, Z., Zhufu, X., Zhang, X., Wu, H., Rui, X., & Zhao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1898280
Gu, Y., Gu, C., Pan, R., & Liu, B. (2026) · Cells · doi:10.3390/cells15161502
Malla, R. R., & Nagaraju, G. P. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118390
The pathological mechanisms and potential therapeutic strategies for renal anemia
Rao, J.-X., Zhou, H.-M., Leu, K. F., Liu, M., Liu, Z.-F., & Tang, Y.-P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1847564
Xu, Z., Wang, L., Zhang, X., & Qi, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1833078
The Five-Decade Journey of Small Cell Lung Cancer
Chen, R., Xue, C., Zhong, Y., Huang, Q., Fan, Q., Li, Y., Wu, J., Dong, S., Li, X., Xiao, T., et al. (2026) · 癌症：英文版 · doi:10.34133/cancomm.0052
Self-citationMitochondria as central regulators of cancer progression and antitumor immunity
Gómez-Durán, A., & Martínez‐Reyes, I. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.07.005
Aging and Reproductive Cancers: An Integrative View on Cell-Free DNA and Transposable Elements
Cecati, M., Vaiasicca, S., Cianfruglia, L., Fumarola, S., Campagna, R., Marchegiani, F., & Cardelli, M. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl50970
Wang, W., Liu, Y., Song, J., Yu, Z., Chen, Z., & Hu, J. (2026) · Antioxidants · doi:10.3390/antiox15091120
Miao, T., Zhao, J., Wu, J., Hou, J., Ma, T., & Wang, G. (2026) · Cancer Biology & Therapy · doi:10.1080/15384047.2026.2728335
Ke, J., Liu, F., Li, C., Yan, Y., Li, X., Han, M., Miao, Q., Li, X., Ji, B., & Yan, F. (2026) · Advanced Materials · doi:10.1002/adma.75010
Liao, Y., Zhu, C., Zhang, W., Cheng, L.-D., Liu, Y., Wang, Y., Zhou, T., Zhao, J.-X., Bian, J., Zou, Z., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108454
Multidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics
Lv, Z., Liu, Y., Liu, Y., Tan, Y., Man, Y., Shuqing, D., Zhang, Z., Lee, L. P., Chen, Q., & Liu, Z. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6c00849
Jia, W., Yu, G., Han, S., Ma, Z., Liang, J., Yan, W., Zhang, X., Zeng, C., Xue, L., Feng, X., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.aea4179
Ye, W., Zhong, L., Wang, X., & Chen, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1941227
Self-citationWang, H., Chen, C., Xiao, J., Zheng, R.-Q., He, W., Xu, Z., Wei, S.-F., Su, T., Zhou, G., & Liu, Y. (2026) · Phytotherapy Research · doi:10.1002/ptr.70460
Das, A., Lalu, E., Awasthi, V., Dhaou, C. B., Hussein, H., Gerhard, G. S., Bahmed, K., Lee, I., Puri, V., & Bouchareb, R. (2026) · Cells · doi:10.3390/cells15191746
Shan, M., Liao, Y., Lin, Z., Song, L., Zhang, W., Jiang, R., Zhang, H., Guo, Y., & Su, F. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02450-8
Wang, P., Zhuang, H., Li, J., Song, X., Wu, S., He, Y., Jing, H., Qiu, X., & Lin, F. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06230-y
Tian, Y., Ma, S., Yang, B., Gao, F., Guo, H., Liu, H., Wu, X., Cui, W., Dong, J., Lin, Q., et al. (2026) · Advanced Science · doi:10.1002/advs.77698
Su, Y., Gong, Z., Mu, J., Huang, L., Yang, P., Zhang, C., Zhao, L., Yang, L., Deng, J., & Liao, X. (2026) · Advanced Science · doi:10.1002/advs.77713
The role of mitochondrial DNA and RNA in promoting liver disease pathogenesis
Raj, S., Warhade, A., Kumari, N., Pandey, S., & Babuta, M. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1855694
Radioiodine-induced cGAS-STING signaling and antitumor immunity in thyroid cancer
Gao, F., Zhang, D., Luo, Y., & Li, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1985864
The IKKε-GABPA axis regulates STING transcription to orchestrate antiviral immunity and inflammation
Zhang, J., Zhao, T., Lei, H., Gan, R., Liu, X., Meng, Y., Ren, D., Su, J., Tang, Y., Sun, J., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252599
Self-citationImmunosenescence in tumor progression: From synergistic mechanisms to therapeutic strategies
Chang, F., Dong, C., & Li, B. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105634
Zhang, Y., Zhu, J., 崔力凡, Chen, S., Li, X., Gao, L., Chen, X., Wen, K., Zeng, B., & Qian, Y. (2026) · Biogerontology · doi:10.1007/s10522-026-10515-z
The Genetic and Epigenetic Mechanisms of mtDNA in Regulation of Inflammation and Metabolism
Zhang, Y., 郑言江, Duan, H., & Li, Y. (2026) · The FASEB Journal · doi:10.1096/fj.202600927r
Self-citationYan, J., Zhou, T., Shi, S., Mao, G., Xu, J., Zhang, Y., Zhang, Y., Sun, H., Wang, Y., Wang, X., et al. (2026) · Cell · doi:10.1016/j.cell.2026.09.031 · Cited by 1
Yang, J., Cai, X., He, F., 张君红, Zhang, Z., Yi, Z., Xie, C., & Xu, B. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02903-1
Targeting senescence-mediated immune resistance for enhanced tumor immunotherapy
Chen, S., Su, J., Jin, A., Liu, C., Zhang, P., Xu, Z., Pan, J., Lai, Y., & Yu, H. (2026) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2026.26
STING as a proton channel: Multifaceted roles in immunity and lysosomal homeostasis
Wang, N., Li, Y., Ma, L., Li, Y.-L., Chen, G., & Zeng, B. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102529
Self-citationGasdermin D Activation by Iron Overload Amplifies Allergic Airway Inflammation
Pei, T., & Li, X. (2026) · The FASEB Journal · doi:10.1096/fj.202604032r
Senescence and tumor immunology: A multifaceted interplay of influence
Xie, Y., Zhang, J., Wang, S., Rao, D., Zhang, J., & Ao, Y. (2026) · iScience · doi:10.1016/j.isci.2026.117849
Qian, Y., Weng, Z., Li, N., Zhou, Y., & Pei, H. (2026) · Journal of Extracellular Biology · doi:10.1002/jex2.70193
The Role of Astrocytes in the Inflammatory Response in Neurodiseases
Peng, S., Wang, L., Ouyang, J., & 刘如恩 (2026) · MedComm · doi:10.1002/mco2.71069
Liu, Y., Liang, R., Zhou, Y., Chen, J., Yuan, Z., Wu, H., & Xu, C. S. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115196
Self-citationZhang, Z., Yan, Z., Huang, S., Yang, X., Wang, Q., Huang, J., Wang, H., Du, Y., Qi, T., Hu, L., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112963
Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming
Silva, T. F., Concato, V. M., Bedier, F., Newman, L. A., Kitka, D., Brown, J. A., Victor, B., Kim, M., Vagner, T., Grasso, C. S., et al. (2026) · Advanced Science · doi:10.1002/advs.78406
Jiang, W., Zhang, Z., Li, X., Shi, R., Pan, B., & Yan, H. (2026) · Seminars in Oncology · doi:10.1016/j.seminoncol.2026.152569
Lyu, S., & González-Angulo, E. (2026) · Diagnostics · doi:10.3390/diagnostics16213466
Luo, Y., Yu, H., Zhang, J., Wu, Z., & Zhang, H. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1991837
Naseer, S., Tan, W.-Y., Sow, Y.-T., Wai, Z.-Y., Ramanitharan, S.-S., Bay, P.-E., Chen, C., & Chye, S. M. (2026) · Nutrients · doi:10.3390/nu18213522
Yang, L., Yang, M., Hu, X., Hu, Y., Li, W., Huang, Y., Zhou, M., Zhu, B., Jin, L., Wu, J., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122546
Metadata
- Authors
- Lai, P., Liu, L., Bancaro, N., Troiani, M., Calì, B., Li, Y., Chen, J., Singh, P. K., Arzola, R. A., Attanasio, G., Pernigoni, N., Pasquini, E., Mosole, S., Rinaldi, A., Sgrignani, J., Qiu, S., Song, P., Li, Y., Desbats, M. A., Ángel, A. R., Mestre, R. P., Cavalli, A., Barile, L., de Bono, J., & Alimonti, A.
- Affiliations
- Institute of Oncology Research (CH)
- Institute for Research in Biomedicine (CH)
- West China Hospital of Sichuan University (CN)
- Ente Ospedaliero Cantonale (CH)
- Istituto Cardiocentro Ticino (CH)
- University of Padua (IT)
- Corresponding author
- Alimonti, Andrea
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2025-04
- Volume
- 58
- Issue
- 4
- Pages
- 811-825.e7
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4409254393
- Cited by
- 174
- References
- 65
- Citations by year
- 2026: 139 · 2025: 35
- FWCI
- 64.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (publishedVersion, cc-by-nc)
- IRIS (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc-nd)
- ETH Zürich Research Collection
- Funders
- European Research Council (CoG 683136)
- Cancer Research Foundation Switzerland (KFS-5262-02-2021, KFS-4267-08-2017, RWP-4813-06-2019)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (201274, 176045, 202302, 216062)
- Fondazione AIRC per la ricerca sul cancro ETS (IG 22030)
- ISREC Foundation
- Prostate Cancer Foundation (19CHAL08)
- Novartis Foundation for Medical-Biological Research (21A009)
- Associazione Italiana per la Ricerca sul Cancro
- Portland Community Fund
- Novartis Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- mitochondrial DNA release, cellular senescence, therapy-induced senescence, polymorphonuclear myeloid-derived suppressor cells, cGAS-STING pathway, NF-κB signaling, PERK signaling, extracellular vesicles, voltage-dependent anion channel, tumor immunosuppression, tumor microenvironment, prostate cancer, chemotherapy efficacy, innate immunity
- MeSH terms
- Myeloid-Derived Suppressor Cells, STING Protein, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Animals, DNA, Mitochondrial, Humans, Immune Tolerance, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Neutrophils, Nucleotidyltransferases, Prostatic Neoplasms, Signal Transduction, NF-kappa B, Cellular Senescence, Cell Line, Tumor, Mice, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
