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Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Open accessAbstract
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated with poor clinical outcomes in cancer. Recent studies have indicated key distinctions between MDSCs and classical neutrophils and monocytes, and, in this Review, we discuss new data on the major genomic and metabolic characteristics of MDSCs. We explain how these characteristics shape MDSC function and could facilitate therapeutic targeting of these cells, particularly in cancer and in autoimmune diseases. Additionally, we briefly discuss emerging data on MDSC involvement in pregnancy, neonatal biology and COVID-19. This Review from Gabrilovich and colleagues discusses our current understanding of the development and functions of myeloid-derived suppressor cells (MDSCs). Recent work has identified unique metabolic properties and gene expression patterns in MDSCs that could help in the development of new therapies for cancer and autoimmunity.
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Reduced NK activity is linked to increased cancer susceptibility and metastasis.
“Diminished NK activity has been linked to increased cancer susceptibility and metastasis, highlighting their essential role in immune surveillance within the TME [77].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [77]
The 'Roles of MDSCs in cancer' section reports that depleting NK cells increased lung metastasis in mouse models and that suppressing NK-cell killing promoted metastasis. It does not address whether diminished NK activity increases susceptibility to developing cancer; the metastasis finding is also specific to mouse models. (LLM, conf=0.85)
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Metadata
- Authors
- Veglia, F., Sanseviero, E., & Gabrilovich, D. I.
- Affiliations
- Moffitt Cancer Center (US)
- The Wistar Institute (US)
- AstraZeneca (United States) (US)
- Corresponding author
- Gabrilovich, Dmitry I.
- Venue
- Nature Reviews Immunology
- Published
- 2021-02-01
- Volume
- 21
- Issue
- 8
- Pages
- 485-498
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC7849958
- OpenAlex
- W3127051356
- Semantic Scholar
- 342c4c5d3e0d32d8cda5c709de271256cbf72462
- Cited by
- 1,940
- References
- 148
- Citations by year
- 2026: 361 · 2025: 399 · 2024: 434 · 2023: 339 · 2022: 293 · 2021: 109
- FWCI
- 30.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- myeloid-derived suppressor cells, immunosuppression, neutrophils, monocytes, gene expression profiling, tumor immunosuppression, autoimmune disease, therapeutic targeting, pregnancy, COVID-19 pandemic
- MeSH terms
- Myeloid-Derived Suppressor Cells, COVID-19, SARS-CoV-2, Autoimmune Diseases, Humans, Monocytes, Neoplasms, Neutrophils, Cytokines, Myeloid Cells
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