Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn.) pericarp
Abstract
The litchi pericarp extract was subjected to partition by hexane, ethyl acetate and water. Epicatechin, proanthocyanidin B2 and proanthocyanidin B4 were isolated and purified from the ethyl acetate fraction by reverse-phase high performance liquid chromatography. The immunomodulatory activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were examined using proliferation of mouse splenocytes. The results showed all these samples had much higher stimulatory effects on splenocyte proliferation than that of the reference, rutin. Epicatechin and the ethyl acetate fraction showed a significantly (P<0.05) stimulatory effect when the concentration was up to 12.5 micro g/ml. Proanthocyanidin B2 and proanthocyanidin B4 exhibited little lower stimulatory effects than epicatechin and the ethyl acetate fraction. The anti-breast cancer activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were also evaluated. Epicatechin and proanthocyanidin B2 had lower cytotoxicities to human breast cancer cell MCF-7 and human embryolic lung fibroblast than paclitaxel.
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These polyphenols show metabolic inhibition of xenobiotic-metabolizing enzymes.
“These polyphenols showed metabolic inhibition of xenobiotic-metabolizing enzymes [164], leading to alteration of the mitotic process in the telophase and thus disruption of cell division [159].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [164]
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Important Flavonoids and Their Role as a Therapeutic Agent
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- Authors
- Zhao, M., Yang, B., Wang, J., Liu, Y., Yu, L., & Jiang, Y.
- Affiliations
- South China University of Technology (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhao, Mouming
- Yang, Bao
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 7
- Issue
- 2
- Pages
- 162-166
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2074524416
- Cited by
- 167
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 15 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 15 · 2012: 8
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Keywords
- litchi pericarp, litchi, flavonoids, epicatechin, proanthocyanidins, immunomodulation, splenocyte proliferation, anti-breast cancer activity, MCF-7 cells, cytotoxicity, ethyl acetate fraction, anticancer activity
- MeSH terms
- Acetates, Animals, Antineoplastic Agents, Phytogenic, Catechin, Cell Survival, Female, Fruit, Humans, Mice, Inbred BALB C, Plant Extracts, Spleen, Litchi, Proanthocyanidins, Cell Line, Tumor, Cell Proliferation, Mice
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