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The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
Abstract
There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.
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“Due to their ability to secrete anti-inflammatory cytokines such as IL-10 and vascular endothelial growth factor (VEGF), they are additionally being explored for their immunomodulatory capabilities [76,77].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [77]
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Biomaterial based modulation of macrophage polarization: a review and suggested design principles
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Metadata
- Authors
- Hoogduijn, M. J., Popp, F., Verbeek, R., Masoodi, M., Nicolaou, A., Baan, C., & Dahlke, M.-H.
- Affiliations
- Erasmus MC (NL)
- University of Regensburg (DE)
- University of Bradford (GB)
- Corresponding author
- Hoogduijn, Martin J
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 10
- Issue
- 12
- Pages
- 1496-1500
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2166106062
- Cited by
- 248
- References
- 48
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 15 · 2020: 5 · 2019: 18 · 2018: 26 · 2017: 23 · 2016: 27 · 2015: 23 · 2014: 23 · 2013: 24 · 2012: 17
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Bradford Scholars (University of Bradford) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, immunomodulation, immunotherapy, graft-versus-host disease, Crohn's disease, organ transplantation, cytokine production, chemokines, prostaglandins, anti-inflammatory activity, pro-inflammatory effects
- MeSH terms
- Animals, Clinical Trials as Topic, Graft vs Host Disease, Humans, Immunotherapy, Prostaglandins, Cytokines, Mesenchymal Stem Cells
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