Cited by 248Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

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The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Hoogduijn, Martin J, Popp, Felix, Verbeek, Richard, Masoodi, Mojgan, Nicolaou, Anna, Baan, Carla, Dahlke, Marc-H·2010·International Immunopharmacology

DOI 10.1016/j.intimp.2010.06.019

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Abstract

There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.

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Authors: Hoogduijn, M. J., Popp, F., Verbeek, R., Masoodi, M., Nicolaou, A., Baan, C., & Dahlke, M.-H.
Affiliations: Erasmus MC (NL)
University of Regensburg (DE)
University of Bradford (GB)
Corresponding author: Hoogduijn, Martin J
ORCID: Hoogduijn, Martin J
Popp, Felix
Masoodi, Mojgan
Nicolaou, Anna
Baan, Carla
Dahlke, Marc-H
Venue: International Immunopharmacology
Publisher: Elsevier BV
Published: 2010-12
Volume: 10
Issue: 12
Pages: 1496-1500
ISSN: 1567-5769 (ISSN-L)
DOI: 10.1016/j.intimp.2010.06.019
OpenAlex: W2166106062
Cited by: 248
References: 48
Citations by year: 2026: 3 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 15 · 2020: 5 · 2019: 18 · 2018: 26 · 2017: 23 · 2016: 27 · 2015: 23 · 2014: 23 · 2013: 24 · 2012: 17
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Immunopharmacology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Bradford Scholars (University of Bradford) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: mesenchymal stem cells, immunomodulation, immunotherapy, graft-versus-host disease, Crohn's disease, organ transplantation, cytokine production, chemokines, prostaglandins, anti-inflammatory activity, pro-inflammatory effects
MeSH terms: Animals, Clinical Trials as Topic, Graft vs Host Disease, Humans, Immunotherapy, Prostaglandins, Cytokines, Mesenchymal Stem Cells

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The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

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