Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice
Abstract
Accumulating evidence reveals that lipopolysaccharide (LPS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50mg/kg) for seven days and then treatmented (50mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral mangiferin pre-treatment (50 mg/kg) and treatment (50 mg/kg) following LPS injection in mice ameliorates cognitive deficits by decreasing LPS-induced IL-6 expression and increasing HO-1 expression in mice hippocampi.
“Oral mangiferin pre-treatment (50 mg/kg) and treatment (50 mg/kg) following LPS injection in mice demonstrated that mangiferin ameliorates cognitive deficits by decreasing LPS-induced IL-6 expression and increasing heme oxygenase-1 (HO-1) expression in mice hippocampi.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [70]
Mangiferin attenuates LPS-induced cognitive deficits caused by neuroinflammation.
“Accumulating evidence has revealed that mangiferin is able to attenuate LPS-induced cognitive deficits caused by neuroinflammation (70).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [70]
Cites
André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.012 · Cited by 241 · see citing works
Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C. P., Olajide, O. A., Martínez-Sánchez, G., & Fiebich, B. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.017 · Cited by 95 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“Accumulating evidence has revealed that mangiferin is able to attenuate LPS‑induced cognitive deficits caused by neuro-inflammation (70).”
Self-citation
- Authors
- Fu, Y., Liu, H., Song, C., Zhang, F., Liu, Y., Wu, J., Wen, X., Liang, C., Ma, K., Li, L., Zhang, X., Shao, X., Sun, Y., Du, Y., & Song, Y.
- Affiliations
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Corresponding author
- Song, Yuanjian
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 29
- Issue
- 2
- Pages
- 950-956
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2139019242
- Cited by
- 23
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81371300, 81501042)
- Natural Science Foundation of Jiangsu Province (BK20150218)
- Education Departmental Natural Science Research Funds of Jiangsu Provincial Higher School of China (13KJB310021, 13KJD310003, 12KJB310018)
- Project of Xuzhou Science and Technology Plan (KC14SH076)
- Research Project of Students (KYLX14-1458, KYLX14-1447, 201410313050Y)
- Qing Lan Project of Jiangsu Province
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mangiferin, lipopolysaccharide, cognitive impairment, neuroinflammation, heme oxygenase-1, interleukin-6, hippocampus, neuroprotection, flavonoids
- MeSH terms
- Animals, Body Weight, Hippocampus, Learning, Lipopolysaccharides, Male, Memory, Interleukin-6, Nootropic Agents, Maze Learning, Xanthones, Mice, Heme Oxygenase-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
