Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
Abstract
Mangiferin, a naturally occurring glucosylxanthone, has potent antioxidant and anti-inflammatory properties, as demonstrated in several reports. However, very limited information is available on the effects of this natural polyphenol on microglial activation. Thus, the aim of this study was to examine whether mangiferin is able to reduce prostaglandin E(2) (PGE(2)) and 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) production by lipopolysaccharide (LPS)-activated primary rat microglia. Microglial cells were stimulated with 10ng/ml of LPS in the presence or absence of different concentrations of mangiferin (1-50 microM). After 24h incubation, culture media were collected to measure the production of PGE(2) and 8-iso-PGF(2alpha) using enzyme immunoassays. Protein levels of cyclooxygenase (COX)-1 and COX-2 were studied by immunoblotting after 24h of incubation with LPS. Mangiferin potently reduced LPS-induced PGE(2) synthesis and the formation of 8-iso-PGF(2alpha). Interestingly, mangiferin dose-dependently reduced LPS-induced COX-2 protein synthesis without modifying COX-2 transcription. This was due to a decrease in COX-2 transcript stability. However, mangiferin did not modify LPS-mediated phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), a key factor involved in enhancing COX-2 mRNA stability and COX-2 translation in primary microglia. Mangiferin had no effects on LPS-induced expression of inducible nitric oxide synthase (iNOS) or TNF-alpha production. T…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
By decreasing COX-2 transcript stability, mangiferin potently reduces LPS-induced PGE-2 synthesis and 8-iso-PGF2alpha production.
“By decreasing COX-2 transcript stability, mangiferin potently reduces LPS-induced prostaglandin E2 (PGE-2) synthesis and 8-iso-prostaglandin F2α (8-iso-PGF2α) production (72).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [72]
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
Microglia in health and disease
Kim, S. U., & de Vellis, J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20562 · Cited by 663 · see citing works
Jiang, Q., Elson‐Schwab, I., Courtemanche, C., & Ames, B. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200357097 · Cited by 524 · see citing works
Xanthone Derivatives: New Insights in Biological Activities
Pinto, M. M. M., Sousa, E., & Nascimento, M. S. J. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774370691 · Cited by 482 · see citing works
Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426 · see citing works
Lasa, M., Mahtani, K. R., Finch, A. J., Brewer, G., Saklatvala, J., & Clark, A. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4265-4274.2000 · Cited by 413 · see citing works
Post-transcriptional Control of Cyclooxygenase-2 Gene Expression
Dixon, D. A., Kaplan, C. D., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11750 · Cited by 348 · see citing works
Martı́nez-Sánchez, G., Re, L., Giuliani, A., Sellés, A. J. N., Pérez-Davison, G., & León-Fernández, O. S. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0727 · Cited by 302 · see citing works
Self-citationDar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289 · see citing works
Guha, S., Ghosal, S., & Chattopadhyay, U. (2009) · Chemotherapy · doi:10.1159/000239478 · Cited by 275 · see citing works
Chen, C. A., & Shyu, A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8471-8482.1994 · Cited by 252 · see citing works
Vijitruth, R., Liu, M., Choi, D., Nguyen, X. V., Hunter, R. L., & Bing, G. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-6 · Cited by 236 · see citing works
Expression and Regulation of Cyclooxygenase‐2 in Rat Microglia
Bauer, M. K. A., Lieb, K., Schulze‐Osthoff, K., Berger, T., Gebicke‐Haerter, P. J., Bauer, J., & Fiebich, B. L. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00726.x · Cited by 235 · see citing works
Self-citationHewett, S. J., Uliasz, T. F., Vidwans, A. S., & Hewett, J. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39251-1 · Cited by 227 · see citing works
Candelario-Jalil, E., de Oliveira, A. C. P., Gräf, S., Bhatia, H. S., Hüll, M., Muñoz, E., & Fiebich, B. L. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-25 · Cited by 223 · see citing works
Self-citationCyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors
Fiebich, B. L., Biber, K. P. H., Lieb, K., van Calker, D., Berger, T., Bauer, J., & Gebicke‐Haerter, P. J. (1996) · Glia · doi:10.1002/(sici)1098-1136(199610)18:2 · Cited by 223 · see citing works
Self-citationGebicke‐Haerter, P. J., Bauer, J., Schobert, A., & Northoff, H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00183.1989 · Cited by 216 · see citing works
Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats
Muruganandan, S., Gupta, S., Kataria, M., Lal, J., & Gupta, P. K. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00069-0 · Cited by 216 · see citing works
A p38 MAP kinase inhibitor regulates stability of interleukin‐1‐induced cyclooxygenase‐2 mRNA
Ridley, S. H., Dean, J. L. E., Sarsfield, S. J., Brook, M., Clark, A. R., & Saklatvala, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01342-8 · Cited by 202 · see citing works
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANGS)
Garrido, G. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.003 · Cited by 201 · see citing works
Doller, A., Huwiler, A., Müller, R., Radeke, H. H., Pfeilschifter, J. M., & Eberhardt, W. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0850 · Cited by 191 · see citing works
Candelario‐Jalil, E., González-Falcón, A., Garcia-Cabrera, M., Álvarez, D., Al-Dalain, S. M., Martı́nez, G., León, O. S., & Springer, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01812.x · Cited by 180 · see citing works
Self-citationNeuroprotection by two polyphenols following excitotoxicity and experimental ischemia
Gottlieb, M., Leal‐Campanario, R., Campos‐Esparza, M. R., Sánchez‐Gómez, M. V., Alberdi, E. M., Arranz, A. M., Delgado-Garcia, J. M., Gruart, A., & Matute, C. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.03.017 · Cited by 164 · see citing works
Akundi, R. S., Candelario‐Jalil, E., Hess, S., Hüll, M., Lieb, K., Gebicke‐Haerter, P. J., & Fiebich, B. L. (2005) · Glia · doi:10.1002/glia.20198 · Cited by 141 · see citing works
Self-citationSato, T., Kawamoto, A., Tamura, A., Tatsumi, Y., & Fujii, T. (1992) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.40.721 · Cited by 137 · see citing works
Cok, S. J., Acton, S. J., & Morrison, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302547200 · Cited by 136 · see citing works
Andreu, G. P., Delgado, R., Velho, J. A., Curti, C., & Vercesi, A. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.007 · Cited by 122 · see citing works
Candelario‐Jalil, E., González-Falcón, A., Garcia-Cabrera, M., León, O. S., & Fiebich, B. L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04280.x · Cited by 120 · see citing works
Self-citationBeharka, A. A., Wu, D., Serafini, M., & Meydani, S. N. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00817-6 · Cited by 117 · see citing works
Pepicelli, O., Fedele, E., Berardi, M., Raiteri, M., Levi, G., Greco, A., Ajmone‐Cat, M. A., & Minghetti, L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03150.x · Cited by 114 · see citing works
Garrido, G. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.020 · Cited by 104 · see citing works
Fiebich, B. L., Lieb, K., Hüll, M., Aicher, B., van Ryn, J., Pairet, M., & Engelhardt, G. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00045-9 · Cited by 96 · see citing works
Self-citationInhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
Lieb, K. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00076-1 · Cited by 80 · see citing works
Ibarretxe, G., Sánchez‐Gómez, M. V., Campos‐Esparza, M. R., Alberdi, E. M., & Matute, C. (2005) · Glia · doi:10.1002/glia.20267 · Cited by 78 · see citing works
de Oliveira, A. C. P., Candelario‐Jalil, E., Bhatia, H. S., Lieb, K., Hüll, M., & Fiebich, B. L. (2008) · Glia · doi:10.1002/glia.20658 · Cited by 77 · see citing works
Self-citationMuruganandan, S., Lal, J., & Gupta, P. K. (2005) · Toxicology · doi:10.1016/j.tox.2005.06.008 · Cited by 77 · see citing works
Pepicelli, O., Fedele, E., Bonanno, G., Raiteri, M., Ajmone‐Cat, M. A., Greco, A., Levi, G., & Minghetti, L. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00897.x · Cited by 73 · see citing works
Martı́nez-Sánchez, G., Candelario‐Jalil, E., Giuliani, A., León, O. S., Sam, S., Delgado, R., & Sellés, A. J. N. (2001) · Free Radical Research · doi:10.1080/10715760100301481 · Cited by 65 · see citing works
Self-citationAmazzal, L., Lapôtre, A., Quignon, F., & Bagrel, D. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.025 · Cited by 64 · see citing works
Candelario‐Jalil, E., Akundi, R. S., Bhatia, H. S., Lieb, K., Appel, K., Muñóz, E., Hüll, M., & Fiebich, B. L. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.01.003 · Cited by 59 · see citing works
Self-citationLeiro, J. M., García, D., Arranz, J. A., Delgado, R., Sanmartín, M. L., & Orallo, F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.02.003 · Cited by 58 · see citing works
Hüll, M., Müksch, B., Akundi, R. S., Waschbisch, A., Hoozemans, J. J. M., Veerhuis, R., & Fiebich, B. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.08.013 · Cited by 45 · see citing works
Self-citationGarrido, G., González, D., Lemus, Y., Delporte, C. L., & Delgado, R. (2005) · Phytomedicine · doi:10.1016/j.phymed.2004.12.003 · Cited by 44 · see citing works
Pardo‐Andreu, G. L., Cavalheiro, R. A., Dorta, D. J., Naal, Z., Delgado, R., Vercesi, A. E., & Curti, C. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112003 · Cited by 40 · see citing works
Pardo‐Andreu, G. L., Delgado, R., Sellés, A. J. N., & Vercesi, A. E. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2005.06.006 · Cited by 38 · see citing works
Dai, R., Li, K., Li, Q., & Bi, K. (2004) · Journal of Chromatographic Science · doi:10.1093/chromsci/42.4.207 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works
Functional foods and their impact on health
Essa, M. M., Bishir, M., Bhat, A., Chidambaram, S. B., Al‐Balushi, B., Hamdan, H., Govindarajan, N., Freidland, R. P., & Qoronfleh, M. W. (2021) · Journal of Food Science and Technology · doi:10.1007/s13197-021-05193-3 · Cited by 221 · see citing works
Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
Activated microglia in the spinal cord underlies diabetic neuropathic pain
Wang, D., Couture, R., & Hong, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.057 · Cited by 146 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“By decreasing COX-2 transcript stability, mangiferin potently reduces LPS-induced prostaglandin E2 (PGE-2) synthesis and 8-iso-prostaglandin F2 α (8-iso-PGF2 α ) production (72).”
Bioactive Compounds in Mango (Mangifera indica L.)
Ribeiro, S. M. R., & Schieber, A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374628-3.00034-7 · Cited by 136 · see citing works
Cerella, C., Sobolewski, C., Dicato, M., & Diederich, M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.050 · Cited by 129 · see citing works
Pharmacological Activities of Mango (Mangifera Indica): A Review
Parvez, G. M. (2016) · Journal of Pharmacognosy and Phytochemistry · Cited by 116 · see citing works
Mangos and their bioactive components: adding variety to the fruit plate for health
Burton‐Freeman, B. M., Sandhu, A. K., & Edirisinghe, I. (2017) · Food & Function · doi:10.1039/c7fo00190h · Cited by 114 · see citing works
Anti-Inflammatory and Anticancer Drugs from Nature
Orlikova, B., Legrand, N., Panning, J., Dicato, M., & Diederich, M. (2014) · Cancer Treatment and Research · doi:10.1007/978-3-642-38007-5_8 · Cited by 108 · see citing works
Pan, C.-W., Pan, Z.-Z., Hu, J.-J., Chen, W.-L., Zhou, G.-Y., Lin, W., Jin, L.-X., & Xu, C.-L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.006 · Cited by 105 · see citing works
Therapeutic and cosmetic applications of mangiferin: A patent review
Telang, M., Dhulap, S., Mandhare, A., & Hirwani, R. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.836182 · Cited by 103 · see citing works
Feng, S.-T., Wang, Z.-Z., Yuan, Y.-H., Sun, H.-M., Chen, N.-H., & Zhang, Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104336 · Cited by 96 · see citing works
Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia
Olajide, O. A., Kumar, A., Velagapudi, R., Okorji, U. P., & Fiebich, B. L. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400163 · Cited by 94 · see citing works
Self-citationAlzheimer’s disease: natural products as inhibitors of neuroinflammation
Olajide, O. A., & Sarker, S. D. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00751-1 · Cited by 91 · see citing works
Self-citationMorozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
Studying neurodegenerative diseases in culture models
Schlachetzki, J. C. M., Saliba, S. W., & de Oliveira, A. C. P. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1159 · Cited by 80 · see citing works
Gong, X., Zhang, L., Jiang, R., Ye, M., Yin, X., & Wan, J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.09.003 · Cited by 79 · see citing works
Belamcandae chinensis rhizoma – a review of phytochemistry and bioactivity
Woźniak, D., & Matkowski, A. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.08.015 · Cited by 76 · see citing works
Ang, E. S. M., Liu, Q., Qi, M., Liu, H. G., Yang, X., Chen, H., Zheng, M., & Xu, J. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22800 · Cited by 76 · see citing works
Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review
Zhang, L., Wei, K., Xu, J., Yang, D., Zhang, C., Wang, Z., & Li, M. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.046 · Cited by 75 · see citing works
Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
Bhatia, H. S., Baron, J., Hagl, S., Eckert, G. P., & Fiebich, B. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0615-6 · Cited by 72 · see citing works
Self-citationZhu, X., Cheng, Y.-Q., Du, L., Li, Y., Zhang, F., Guo, H., Liu, Y.-W., & Yin, X.-X. (2015) · Phytotherapy Research · doi:10.1002/ptr.5254 · Cited by 66 · see citing works
Kang, M., Jung, I., Hur, J.-H., Kim, S. H., Lee, J. H., Kang, J.-Y., Jung, K. C., Kim, K. S., Yoo, M. C., Park, D., et al. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.07.025 · Cited by 66 · see citing works
Pharmacologic Activities of Plant‐Derived Natural Products on Respiratory Diseases and Inflammations
Timalsina, D., Pokhrel, K. P., & Bhusal, D. (2021) · BioMed Research International · doi:10.1155/2021/1636816 · Cited by 58 · see citing works
A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin
Garrido‐Suárez, B. B., Garrido, G., Delgado, R., Bosch, F., & Rabí, M. D. C. (2010) · Molecules · doi:10.3390/molecules15129035 · Cited by 58 · see citing works
In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity
Chieli, E., Romiti, N., Rodeiro, I., & Garrido, G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.07.017 · Cited by 54 · see citing works
Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities
Pierson, J. T., Dietzgen, R. G., Shaw, P. N., Roberts‐Thomson, S. J., Monteith, G. R., & Gidley, M. J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100441 · Cited by 53 · see citing works
Hernández-Maldonado, L. M., Blancas‐Benítez, F. J., Zamora-Gasga, V. M., Cárdenas-Castro, A. P., Tovar, J., & Sáyago‐Ayerdi, S. G. (2019) · Nutrients · doi:10.3390/nu11071564 · Cited by 53 · see citing works
Olajide, O. A., Aderogba, M. A., & Fiebich, B. L. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.10.031 · Cited by 51 · see citing works
Self-citationWalia, V., Chaudhary, S. K., & Kumar Sethiya, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104939 · Cited by 51 · see citing works
Inhibition of Microglia Activation as a Phenotypic Assay in Early Drug Discovery
Figuera-Losada, M., Rojas, C. J., & Slusher, B. S. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113499406 · Cited by 50 · see citing works
Živković, J., Kumar, K. A., Rushendran, R., Ilango, K., Fahmy, N. M., El‐Nashar, H. A. S., El‐Shazly, M., Ezzat, S. M., Melgar‐Lalanne, G., Romero‐Montero, A., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02682-4 · Cited by 56 · see citing works
Mangiferin: A promising therapeutic agent for rheumatoid arthritis treatment
Łuczkiewicz, P., Kokotkiewicz, A., Dampc, A., & Łuczkiewicz, M. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.021 · Cited by 44 · see citing works
Bhatia, H. S., Roelofs, N., Muñóz, E., & Fiebich, B. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-00225-5 · Cited by 46 · see citing works
Self-citationNeuroprotective mechanisms of mangiferin in neurodegenerative diseases
Liu, T., Song, Y., & Hu, A. (2021) · Drug Development Research · doi:10.1002/ddr.21783 · Cited by 43 · see citing works
Cao, C., Su, M., & Zhou, F. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000305 · Cited by 42 · see citing works
Razura-Carmona, F. F., Pérez-Larios, A., González-Silva, N., Herrera-Martínez, M., Medina-Torres, L., Sáyago-Ayerdi, S. G., & Sánchez-Burgos, J. A. (2019) · Cancers · doi:10.3390/cancers11121965 · Cited by 40 · see citing works
LEI, L.-Y., WANG, R.-C., PAN, Y.-L., YUE, Z.-G., ZHOU, R., XIE, P., & TANG, Z.-S. (2021) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(21)60012-2 · Cited by 39 · see citing works
The multifaceted role of mangiferin in health and diseases: a review
Jangra, A., Arora, M. K., Kisku, A., & Sharma, S. (2020) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00471-5 · Cited by 37 · see citing works
Cao, X., Shang, Y., Kong, W., Jiang, S., Liao, J., & Dai, R. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114740 · Cited by 36 · see citing works
Lum, P. T., Sekar, M., Seow, L.-J., Shaikh, M. F., Arulsamy, A., Retinasamy, T., Gan, S. H., Gnanaraj, C., Esa, N. M., Ramachawolran, G., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1189957 · Cited by 36 · see citing works
Heat acclimation affects circulating levels of prostaglandin E2, COX-2 and orexin in humans
Shin, Y. O., Lee, J. B., Min, Y. K., & Yang, H. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.017 · Cited by 33 · see citing works
Rahman, M. H., Jha, M. K., & Suk, K. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151204001234 · Cited by 36 · see citing works
Cheng, D., Zhang, Y., Gao, D., & Zhang, H. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.07.029 · Cited by 32 · see citing works
Wongwad, E., Pingyod, C., Saesong, T., Waranuch, N., Wisuitiprot, W., Sritularak, B., Temkitthawon, P., & Ingkaninan, K. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.06.011 · Cited by 31 · see citing works
Swain, S., Koduru, J. R., & Rautray, T. R. (2023) · Materials · doi:10.3390/ma16062206 · Cited by 30 · see citing works
Qu, Y., Zhou, L., & Wang, C. (2016) · Inflammation · doi:10.1007/s10753-016-0451-y · Cited by 28 · see citing works
Wang, J., Nie, Y., Li, Y., Hou, Y., Zhao, W. G., Deng, J., Wang, P. G., & Bai, G. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04439 · Cited by 27 · see citing works
Мозес, В. Г., Korotkevich, O., Анатольевна, Ю. М., Ивановна, Е. С., Владимировна, Р. Е., Борисовна, М. К., & Евгеньевна, П. Т. (2025) · Matʹ i ditâ v Kuzbasse · doi:10.24412/2686-7338-2025-2-61-64 · Cited by 26 · see citing works
Olajide, O. A., Aderogba, M. A., Okorji, U. P., & Fiebich, B. L. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/546873 · Cited by 25 · see citing works
Self-citationAnti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats
Garrido‐Suárez, B. B., Garrido, G., Castro-Labrada, M., Merino, N., Valdés, O., Rodeiro, I., Hernández, I., Figueiredo, J. G., Ferreira, S. H., & Delgado, R. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.019 · Cited by 25 · see citing works
Fu, Y., Zhang, F., Zhang, L., Liu, H., Zhao, Z., Wen, X., Wu, J. H., Qi, D., Sun, Y., Du, Y., et al. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0039-8 · Cited by 25 · see citing works
Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice
Fu, Y., Liu, H., Song, C., Zhang, F., Liu, Y., Wu, J., Wen, X., Liang, C., Ma, K., Li, L., et al. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.035 · Cited by 23 · see citing works
Tiwari, P. C., Chaudhary, M. J., Pal, R., Kartik, S., & Nath, R. (2021) · Annals of Neurosciences · doi:10.1177/09727531211051976 · Cited by 23 · see citing works
Monteros-Zúñiga, A. E. D. L., Izquierdo, T., Quiñonez‐Bastidas, G. N., Rocha-González, H. I., & Godínez‐Chaparro, B. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.10.007 · Cited by 22 · see citing works
Therapeutic Potential of the Natural Product Mangiferin in Metabolic Syndrome
Mirza, R. H., Chi, N., & Chi, Y. (2013) · Journal of Nutritional Therapeutics · doi:10.6000/1929-5634.2013.02.02.2 · Cited by 21 · see citing works
Zhang, H., Hou, Y., Liu, Y., Yu, X., Li, B., & Cui, H. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0024 · Cited by 21 · see citing works
Phytochemical and pharmacological investigations on mangiferin.
Singh, S. K., Sharma, V., Kumar, Y., Sadasivam, S., & Sinha, S. (2009) · Herba Polonica · Cited by 20 · see citing works
Selected natural phenolic compounds - potential treatment for peripheral neuropathy?
Šmejkal, K. (2014) · Česká a slovenská farmacie · doi:10.36290/csf.2014.012 · Cited by 18 · see citing works
Mantecón, A. M. L., Garrido, G., Delgado, R., & Garrido‐Suárez, B. B. (2013) · Phytotherapy Research · doi:10.1002/ptr.5108 · Cited by 17 · see citing works
Zhong, Y.-M., Xu, Y.-Y., Tan, Y.-Z., Zhang, X.-X., Wang, R.-L., Chen, D.-M., Wang, Z.-T., & Zhong, X.-L. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115386 · Cited by 13 · see citing works
Zizzo, M. G., Caldara, G., Bellanca, A., Nuzzo, D., Carlo, M. D., Scoglio, S., & Serio, R. (2020) · Nutrients · doi:10.3390/nu12123635 · Cited by 17 · see citing works
The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia
Garcia-Partida, J. A., Torres-Sánchez, S., MacDowell, K. S., Fernández-Ponce, M. T., Casas, L., Mantell, C., Soto‐Montenegro, M. L., Romero‐Miguel, D., Lamanna‐Rama, N., Leza, J. C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.886514 · Cited by 15 · see citing works
Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain
Garrido‐Suárez, B. B., Garrido, G., Piñeros, O., & Delgado, R. (2019) · Phytotherapy Research · doi:10.1002/ptr.6546 · Cited by 15 · see citing works
Akkewar, A. S., Mishra, K. A., & Sethi, K. K. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23765 · Cited by 14 · see citing works
Ain, Q. U., Iqbal, M. O., Khan, I. A., Bano, N., Naeem, M., Jamaludin, M. I., & Devaraj, S. (2023) · PubMed Central · Cited by 13 · see citing works
Chang, T., Neelakandan, C., DeFine, L. A., Alexander, T. S., & Kyu, T. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp5080187 · Cited by 13 · see citing works
Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
Chomchoei, N., Leelapornpisid, P., Tipduangta, P., Sangthong, P., Papan, P., Sirithunyalug, B., & Samutrtai, P. (2023) · RSC Advances · doi:10.1039/d3ra06308a · Cited by 12 · see citing works
Rocha, L. W., Bonet, I. J. M., Tambeli, C. H., de‐Faria, F. M., & Parada, C. A. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.030 · Cited by 12 · see citing works
Ahmad, N., Khan, M. F., Ullah, Z., Chaudhary, A. A., Alawam, A. S., Khalid, M. S., & Ali, M. T. (2023) · Polymer Bulletin · doi:10.1007/s00289-023-05030-x · Cited by 11 · see citing works
MANGIFERIN: A POTENTIAL NATURAL MOLECULE FOR MANAGEMENT OF METABOLIC SYNDROME
Mujawdiya, P. K., & Kapur, S. (2015) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 10 · see citing works
[The copper concentration in the blood serum of women with ovarian tumors (a preliminary report)].
Marinov, B., Tsachev, K., Doganov, N., Dzherov, L., Atanasova, B. D., & Marková, M. (2000) · PubMed · Cited by 10 · see citing works
Prostate cancer: risk categories and role of hormones and radiotherapy.
Lukka, H. R. (2002) · PubMed · Cited by 10 · see citing works
Guo, Y.-P., Yi, P., Shi, Q.-Q., Yu, R.-R., Wang, J., Li, C., & Wu, H. (2023) · Molecules · doi:10.3390/molecules28124715 · Cited by 9 · see citing works
Synthesis and Biological Evaluation of 12-Aminoacylphorboids
Pagani, A., Navarrete, C. M., Fiebich, B. L., Muñóz, E., & Appendino, G. (2010) · Journal of Natural Products · doi:10.1021/np9006553 · Cited by 9 · see citing works
Self-citationGarrido‐Suárez, B. B., Garrido, G., García, M. E., & Delgado, R. (2014) · Phytotherapy Research · doi:10.1002/ptr.5177 · Cited by 8 · see citing works
Case Series in Patients with Zoster-Associated Pain Using Mangifera indica L. Extract
Garrido‐Suárez, B. B., Garrido, G., Delgado, R., Bosch, F., & Rabí, M. D. C. (2011) · Forschende Komplementärmedizin / Research in Complementary Medicine · doi:10.1159/000335124 · Cited by 8 · see citing works
Kim, K.-S., Choi, H.-M., Yang, H.-I., & Yoo, M.-C. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.1.050 · Cited by 8 · see citing works
Analgesic and Anti-inflammatory Activities of Urena lobata L. Leaf Extracts
Purnomo, Y., & Tilaqza, A. (2022) · INDONESIAN JOURNAL OF PHARMACY · doi:10.22146/ijp.2145 · Cited by 7 · see citing works
Shin, Y. O., Lee, J. B., Song, Y. J., Min, Y. K., & Yang, H. M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2543 · Cited by 7 · see citing works
Pharmacological Effects of Mangiferin
Zhi-quan, W., Deng, J., & Li, Y. (2011) · Cited by 6 · see citing works
Moreira, M. E. D. C., Pereira, R. G. F. A., Silva, M. J. D., Dias, D. F., Gontijo, V. S., Giusti‐Paiva, A., Veloso, M. P., Doriguetto, A. C., Nagem, T. J., & dos Santos, M. H. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0122 · Cited by 6 · see citing works
Effects of Dietary Components on Microglia Inactivation in Alzheimer’s Disease
Bhatia, H. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00008-0 · Cited by 5 · see citing works
Self-citationAntioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models
Paradee, N., Janthip, R., Taesothikul, T., Kanjanapothi, D., Settakorn, K., Srichairatanakool, S., & Koonyosying, P. (2023) · Applied Sciences · doi:10.3390/app132212216 · Cited by 4 · see citing works
Zahid, H. F., Ranadheera, C. S., Fang, Z., & Ajlouni, S. (2019) · International Journal of Agriculture Environment and Bioresearch · doi:10.35410/ijaeb.2019.4451 · Cited by 4 · see citing works
Impacts of Mild Hypothermia on LPS-Mediated TLR4/NF-κB Signaling Pathway in Microglia
Liu, L., Li, X., Wang, Y., Cao, F., Zhang, S., Zhan, Z., Meng, Y., & Xie, Q. (2019) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2019.72008 · Cited by 2 · see citing works
Garrido‐Suárez, B. B., Castro-Labrada, M., Merino, N., Valdés, O., & Delgado, R. (2011) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres14.017_2.2.36 · Cited by 2 · see citing works
AKTIVITAS ANALGESIK INFUSA DAN DEKOKTA DAUN PULUTAN (Urena lobata)
Purnomo, Y., & Tilaqza, A. (2022) · Jurnal Wiyata: Penelitian Sains dan Kesehatan · doi:10.56710/wiyata.v9i1.586 · Cited by 1 · see citing works
Unveiling Nature’s Arsenal: Natural Sources for Drug Discovery in Alzheimer’s Disease
Remya, C., Aiswarya, N., & Dileep, K. V. (2024) · Springer eBooks · doi:10.1007/978-981-99-9183-9_13 · Cited by 1 · see citing works
Ghazy, E., Mokhbatly, A.-A. A., Keniber, S., & Shoghy, K. M. (2019) · Slovenian Veterinary Research · doi:10.26873/svr-793-2019 · Cited by 1 · see citing works
Garrido, G. (2016) · Anales de la Academia de Ciencias de Cuba
Patange, S., Basak, S., & Singhal, R. S. (2026) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2026.107194
- Authors
- Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C. P., Olajide, O. A., Martínez-Sánchez, G., & Fiebich, B. L.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Fiebich, Bernd L.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 477
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2042159604
- Cited by
- 95
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 8 · 2012: 5
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
- Funders
- American Heart Association
- Alexander von Humboldt-Stiftung
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- mangiferin, microglial activation, cyclooxygenase-2, prostaglandin E2, 8-isoprostane, lipopolysaccharide, p38 MAPK, neuroinflammation, cerebral protection, inducible nitric oxide synthase, TNF-α
- MeSH terms
- Animals, Animals, Newborn, Brain, Cells, Cultured, Dose-Response Relationship, Drug, Lipopolysaccharides, Dinoprostone, Signal Transduction, Rats, Sprague-Dawley, Microglia, Oxidative Stress, Xanthones, Rats, Cyclooxygenase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review