Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation

Analyzing real-time PCR data by the comparative CT method

Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies

Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Regional dissociations within the hippocampus-memory and anxiety

Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works

Amygdala circuitry mediating reversible and bidirectional control of anxiety

Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works

Systemic infections and inflammation affect chronic neurodegeneration

Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027 · see citing works

Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912 · see citing works

Obesity and infection

Falagas, M. E., & Kompoti, M. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70523-0 · Cited by 820 · see citing works

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works

Obesity and the risk and outcome of infection

Huttunen, R., & Syrjänen, J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.62 · Cited by 595 · see citing works

Cognitive impairment following high fat diet consumption is associated with brain inflammation

Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 594 · see citing works

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., Deacon, R. M. J., Rawlins, J. N. P., & Perry, V. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.024 · Cited by 584 · see citing works

The medical complications of obesity

Malnick, S. D. H. (2006) · QJM · doi:10.1093/qjmed/hcl085 · Cited by 579 · see citing works

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.002 · Cited by 565 · see citing works

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

Lucki, I., Dalvi, A., & Mayorga, A. J. (2001) · Psychopharmacology · doi:10.1007/s002130100694 · Cited by 506 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works

Immunological complications of obesity

Kanneganti, T., & Dixit, V. D. (2012) · Nature Immunology · doi:10.1038/ni.2343 · Cited by 481 · see citing works

Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior

Frenois, F., Moreau, M., O’Connor, J., Lawson, M., Micon, C., Lestage, J., Kelley, K. W., Dantzer, R., & Castanon, N. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.005 · Cited by 438 · see citing works

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

Walker, A. K., Budac, D. P., Bisulco, S., Lee, A. W., Smith, R. A., Beenders, B., Kelley, K. W., & Dantzer, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.71 · Cited by 432 · see citing works

Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry

Sharma, S., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.48 · Cited by 424 · see citing works

Review article: Is obesity an inflammatory illness? Role of low‐grade inflammation and macrophage infiltration in human white adipose tissue

Cancello, R., & Clément, K. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01004.x · Cited by 418 · see citing works

Obesity and mental disorders in the adult general population

Scott, K. M., McGee, M. A., Wells, J. E., & Oakley Browne, M. A. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.09.006 · Cited by 393 · see citing works

Neurobiology of depression: an integrated view of key findings

Maletic, V., Robinson, M., Oakes, T. M. M., Iyengar, S., Ball, S. G., & Russell, J. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01602.x · Cited by 387 · see citing works

High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

Thirumangalakudi, L., Prakasam, A., Zhang, R., Bimonte‐Nelson, H. A., Sambamurti, K., Kindy, M. S., & Bhat, N. R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05415.x · Cited by 360 · see citing works

The longer-term impacts of Western diet on human cognition and the brain

Francis, H., & Stevenson, R. J. (2013) · Appetite · doi:10.1016/j.appet.2012.12.018 · Cited by 342 · see citing works

Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats

Boitard, C., Cavaroc, A., Sauvant, J., Aubert, A., Castanon, N., Layé, S., & Ferreira, G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.005 · Cited by 324 · see citing works

Induction of IDO by Bacille Calmette-Guérin Is Responsible for Development of Murine Depressive-Like Behavior

O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works

Genetic Differences in Response to Novelty and Spatial Memory Using a Two-Trial Recognition Task in Mice

Dellu, F., Contarino, A., Simon, H., Koob, G. F., & Gold, L. H. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3919 · Cited by 303 · see citing works

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299 · see citing works

Cognitive and Emotional Alterations Are Related to Hippocampal Inflammation in a Mouse Model of Metabolic Syndrome

Dinel, A., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024325 · Cited by 264 · see citing works

Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge

Salazar, A., Gonzalez-Rivera, B. L., Redus, L., Parrott, J. M., & O’Connor, J. C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.03.010 · Cited by 261 · see citing works

Juvenile, but not adult exposure to high‐fat diet impairs relational memory and hippocampal neurogenesis in mice

Boitard, C., Etchamendy, N., Sauvant, J., Aubert, A., Tronel, S., Marighetto, A., Layé, S., & Ferreira, G. (2012) · Hippocampus · doi:10.1002/hipo.22032 · Cited by 258 · see citing works

Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge

Amar, S., Zhou, Q., Shaik-Dasthagirisaheb, Y. B., & Leeman, S. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710335105 · Cited by 250 · see citing works

Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity

Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., & Nakao, K. (2011) · Endocrinology · doi:10.1210/en.2011-0004 · Cited by 247 · see citing works

Diet Induction of Monocyte Chemoattractant Protein‐1 and its Impact on Obesity

Chen, A., Mumick, S., Zhang, C., Lamb, J., Dai, H., Weingarth, D., Mudgett, J., Chen, H., MacNeil, D. J., Reitman, M. L., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.159 · Cited by 231 · see citing works

Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism

Oxenkrug, G. F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05356.x · Cited by 221 · see citing works

Diabetes Prolongs the Inflammatory Response to a Bacterial Stimulus Through Cytokine Dysregulation

Naguib, G. H., Almashat, H., Desta, T., & Graves, D. T. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22711.x · Cited by 221 · see citing works

Depressive symptoms and metabolic syndrome: is inflammation the underlying link?

Capuron, L., Su, S., Miller, A. H., Bremner, J. D., Goldberg, J., Vogt, G. J., Maisano, C., Jones, L., Murrah, N. V., & Vaccarino, V. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.019 · Cited by 219 · see citing works

Obesity and vulnerability of the CNS

Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.004 · Cited by 200 · see citing works

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.06.008 · Cited by 195 · see citing works

Elevated Prevalence of Obesity, Metabolic Syndrome, and Cardiovascular Risk Factors in Bipolar Disorder

Fiedorowicz, J. G., Palagummi, N. M., Forman‐Hoffman, V. L., Miller, D. D., & Haynes, W. G. (2008) · Annals of Clinical Psychiatry · doi:10.1080/10401230802177722 · Cited by 185 · see citing works

Cognitive Function and Decline in Obesity

Stanek, K. M., & Gunstad, J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111073 · Cited by 178 · see citing works

The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen

Lestage, J., Verrier, D., Palin, K., & Dantzer, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00014-4 · Cited by 170 · see citing works

Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior

Moreau, M. M., André, C., O’Connor, J. C., Dumich, S. A., Woods, J. A., Kelley, K. W., Dantzer, R., Lestage, J., & Castanon, N. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.001 · Cited by 168 · see citing works

Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?

Valladolid‐Acebes, I., Fole, A., Martín, M. E., Morales, L., Cano, V., Ruiz‐Gayo, M., & Olmo, N. D. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.012 · Cited by 145 · see citing works

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

Lu, J. L., Wu, D., Zheng, Y., Hu, B., Cheng, W., Zhang, Z.-F., & Shan, Q. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.009 · Cited by 141 · see citing works

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Fu, X., Zunich, S. M., O’Connor, J. C., Kavelaars, A., Dantzer, R., & Kelley, K. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-43 · Cited by 130 · see citing works

Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring

Babri, S., Doosti, M.-H., & Salari, A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.003 · Cited by 120 · see citing works

Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation

Capuron, L., Poitou, C., Machaux-Tholliez, D., Frochot, V., Bouillot, J., Basdevant, A., Layé, S., & Clément, K. (2010) · Psychological Medicine · doi:10.1017/s0033291710001984 · Cited by 115 · see citing works

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

Chess, A. C., Landers, A., & Bucci, D. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.013 · Cited by 113 · see citing works

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

André, C., O’Connor, J. C., Kelley, K. W., Lestage, J., Dantzer, R., & Castanon, N. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.011 · Cited by 111 · see citing works

Chronic Immune Activation Underlies Morbid Obesity: Is IDO A Key Player?

Brandacher, G., Hoeller, E., Fuchs, D., & Weiss, H. G. (2007) · Current Drug Metabolism · doi:10.2174/138920007780362590 · Cited by 111 · see citing works

Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice

Labrousse, V. F., Costes, L., Aubert, A., Darnaudéry, M., Ferreira, G., Amédée, T., & Layé, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006006 · Cited by 106 · see citing works

Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice

Moreau, M. M., Lestage, J., Verrier, D., Mormède, C., Kelley, K. W., Dantzer, R., & Castanon, N. (2005) · The Journal of Infectious Diseases · doi:10.1086/431603 · Cited by 104 · see citing works

Plasma Transcortin Influences Endocrine and Behavioral Stress Responses in Mice

Richard, É. M., Helbling, J., Tridon, C., Desmedt, A., Minni, A., Cador, M., Pourtau, L., Konsman, J. P., Mormède, P., & Moisan, M. (2009) · Endocrinology · doi:10.1210/en.2009-0862 · Cited by 100 · see citing works

Role of brain transmigrating neutrophils in depression-like behavior during systemic infection

Aguliar-Valles, A., Kim, J., Jung, S., Woodside, B., & Luheshi, G. N. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.137 · Cited by 97 · see citing works

The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment

Gold, A. B., Herrmann, N., Swardfager, W., Black, S. E., Aviv, R. I., Tennen, G., Kiss, A., & Lanctôt, K. L. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-17 · Cited by 95 · see citing works

IL-1β-Mediated Innate Immunity Is Amplified in the <i>db/db</i> Mouse Model of Type 2 Diabetes

O’Connor, J. C., Satpathy, A., Hartman, M. E., Horvath, E. M., Kelley, K. W., Dantzer, R., Johnson, R. W., & Freund, G. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4991 · Cited by 86 · see citing works

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 84 · see citing works

Gastric Bypass Surgery is Associated with Reduced Inflammation and Less Depression: a Preliminary Investigation

Emery, C. F., Fondow, M. D. M., Schneider, C., Christofi, F. L., Hunt, C. K., Busby, A. K., NEEDLEMAN, B. J., Melvin, W. S., & Awad, H. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9140-0 · Cited by 84 · see citing works

Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome

Dinel, A., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.014 · Cited by 84 · see citing works

Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

Lawson, M. A., McCusker, R. H., & Kelley, K. W. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-54 · Cited by 80 · see citing works

Prolonged Depression-Like Behavior Caused by Immune Challenge: Influence of Mouse Strain and Social Environment

Painsipp, E., Köfer, M. J., Sinner, F. M., & Holzer, P. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020719 · Cited by 77 · see citing works

C-reactive protein is linked to lower cognitive performance in overweight and obese women

Sweat, V., Starr, V., Bruehl, H., Arentoft, A., Tirsi, A., Javier, E., & Convit, A. (2008) · Inflammation · doi:10.1007/s10753-008-9065-3 · Cited by 72 · see citing works

Changes in Hypothalamically Mediated Acute-Phase Inflammatory Responses to Lipopolysaccharide in Diet-Induced Obese Rats

Pohl, J., Woodside, B. C., & Luheshi, G. N. (2009) · Endocrinology · doi:10.1210/en.2009-0526 · Cited by 72 · see citing works

Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide

Lawrence, C. B., Brough, D., & Knight, E. M. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009068 · Cited by 69 · see citing works

Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 mice

Nikodémová, M., & Watters, J. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.006 · Cited by 62 · see citing works

Up-regulation of muscle UCP2 gene expression by a new β3-adrenoceptor agonist, trecadrine, in obese (cafeteria) rodents, but down-regulation in lean animals

Berraondo, B., Martí, A., Duncan, J., Trayhurn, P., & Martínez, J. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801097 · Cited by 60 · see citing works

Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin

Kelley, K. W., O’Connor, J. C., Lawson, M. A., Dantzer, R., Rodriguez-Zas, S. L., & McCusker, R. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.003 · Cited by 49 · see citing works

Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats

Castanon, N., Medina, C. F., Mormède, C., & Dantzer, R. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00142-2 · Cited by 47 · see citing works

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Thoeringer, C. K., Sillaber, I., Roedel, A., Erhardt, A., Mueller, M. B., Ohl, F., Holsboer, F., & Keck, M. E. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.005 · Cited by 46 · see citing works

Diet-induced weight gain produces a graded increase in behavioral responses to an acute immune challenge

Pohl, J., Sheppard, M., Luheshi, G. N., & Woodside, B. C. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.002 · Cited by 36 · see citing works

Selective Involvement of Interleukin-6 in the Transcriptional Activation of the Suppressor of Cytokine Signaling-3 in the Brain during Systemic Immune Challenges.

Lebel, E., Vallières, L., & Rivest, S. (2000) · Endocrinology · doi:10.1210/endo.141.10.7695 · Cited by 31 · see citing works

Obesity and IL-6 interact in modulating the response to endotoxemia in mice

Pini, M., Castellanos, K. J., Rhodes, D., & Fantuzzi, G. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.027 · Cited by 25 · see citing works

Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 525 · see citing works

The menace of obesity to depression and anxiety prevalence

Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works

Obesity and cognitive decline: role of inflammation and vascular changes

Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 429 · see citing works

The progress of gut microbiome research related to brain disorders

Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works

High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation

Dutheil, S., Ota, K. T., Wohleb, E. S., Rasmussen, K., & Duman, R. S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.357 · Cited by 355 · see citing works

How important is tryptophan in human health?

Kałużna-Czaplińska, J., Gątarek, P., Chirumbolo, S., Chartrand, M. S., & Bjørklund, G. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1357534 · Cited by 333 · see citing works

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Soto, M., Herzog, C., Pacheco, J. A., Fujisaka, S., Bullock, K., Clish, C. B., & Kahn, C. R. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0086-5 · Cited by 216 · see citing works

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Cunningham, C., & Hennessy, E. (2015) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-015-0117-2 · Cited by 211 · see citing works

Central nervous system regulation of eating: Insights from human brain imaging

Farr, O. M., Li, C.-S. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 191 · see citing works

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works

Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

Sun, J., Wang, F., Hong, G., Pang, M., Xu, H., Li, H., Tian, F., Fang, R., Yao, Y., & Liu, J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.003 · Cited by 184 · see citing works

Effects of psychotropic drugs on inflammation:Consequence or mediator of therapeutic effects in psychiatric treatment?

Baumeister, D., Ciufolini, S., & Mondelli, V. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4044-5 · Cited by 183 · see citing works

Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation

André, C., Guzman-Quevedo, O., Rey, C., Rémus-Borel, J., Clark, S., Castellanos-Jankiewicz, A., Ladeveze, E., Leste-Lasserre, T., Nadjar, A., Abrous, D. N., et al. (2017) · Diabetes · doi:10.2337/db16-0586 · Cited by 182 · see citing works

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

Spielman, L. J., Little, J. P., & Klegeris, A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.004 · Cited by 182 · see citing works

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

Castanon, N., Luheshi, G. N., & Layé, S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00229 · Cited by 179 · see citing works

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

Zemdegs, J., Quesseveur, G., Jarriault, D., Pénicaud, L., Fioramonti, X., & Guiard, B. P. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13343 · Cited by 180 · see citing works

Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer

Lanser, L., Kink, P., Egger, E. M., Willenbacher, W., Fuchs, D., Weiß, G., & Kurz, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00249 · Cited by 172 · see citing works

Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review

Skaper, S. D., Facci, L., & Giusti, P. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130224206 · Cited by 168 · see citing works

Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes

Castanon, N., Lasselin, J., & Capuron, L. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00074 · Cited by 160 · see citing works

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

Wang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works

Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids

Zemdegs, J., Martin, H., Pintana, H., Bullich, S., Manta, S., Marqués, M. A., Moro, C., Layé, S., Ducrocq, F., Chattipakorn, N., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2904-18.2019 · Cited by 151 · see citing works

Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

Almeida-Suhett, C. P., Graham, A. M., Chen, Y., & Deuster, P. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.016 · Cited by 142 · see citing works

Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model

Bridgewater, L. C., Zhang, C., Wu, Y., Hu, W., Zhang, Q., Wang, J., Li, S., & Zhao, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-11069-4 · Cited by 136 · see citing works

Cognitive Function and the Microbiome

Gareau, M. G. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.001 · Cited by 131 · see citing works

Decline in Weight and Incident Mild Cognitive Impairment

Alhurani, R. E., Vassilaki, M. E., Aakre, J. A., Mielke, M. M., Kremers, W. K., Machulda, M. M., Geda, Y. E., Knopman, D. S., Petersen, R. C., & Roberts, R. O. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.4756 · Cited by 130 · see citing works

The Role of Oxidative Stress and Inflammation in Obesity and Its Impact on Cognitive Impairments—A Narrative Review

Naomi, R., Teoh, S. H., Embong, H., Balan, S. S., Othman, F., Bahari, H., & Yazid, M. D. (2023) · Antioxidants · doi:10.3390/antiox12051071 · Cited by 121 · see citing works

Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome

de Cossío, L. F., Fourrier, C., Sauvant, J., Everard, A., Capuron, L., Cani, P. D., Layé, S., & Castanon, N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.022 · Cited by 108 · see citing works

High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population

Jeong, M.-Y., Jang, H.-M., & Kim, D.-H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.006 · Cited by 110 · see citing works

Modulation of brain PUFA content in different experimental models of mice

Joffre, C., Gregoire, S., Smedt, V. D., Acar, N., Brétillon, L., Nadjar, A., & Layé, S. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.09.003 · Cited by 104 · see citing works

IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity

Filho, A. J. M. C., Lima, C. N. D. C., Vasconcelos, S. M. M., de Lucena, D. F., Maes, M. H. J., & Macêdo, D. S. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.035 · Cited by 105 · see citing works

Models and mechanisms for hippocampal dysfunction in obesity and diabetes

Stranahan, A. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.045 · Cited by 101 · see citing works

Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms

Vancassel, S., Capuron, L., & Castanon, N. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00499 · Cited by 95 · see citing works

The effect of short-term exposure to energy-matched diets enriched in fat or sugar on memory, gut microbiota and markers of brain inflammation and plasticity

Beilharz, J. E., Kaakoush, N. O., Maniam, J., & Morris, M. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.151 · Cited by 93 · see citing works

The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice

Fu, H., Liu, L., Tong, Y. A., Li, Y., Zhang, X., Gao, X., Yong, J., Zhao, J., Dong, X. Y., Wen, K., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.03.035 · Cited by 92 · see citing works

Short-Term High-Fat Diet (HFD) Induced Anxiety-Like Behaviors and Cognitive Impairment Are Improved with Treatment by Glyburide

Gainey, S. J., Kwakwa, K. A., Bray, J. K., Pillote, M. M., Tir, V. L., Towers, A. E., & Freund, G. G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00156 · Cited by 92 · see citing works

The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function

Hoeijmakers, L., Lucassen, P. J., & Kőrösi, A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00103 · Cited by 92 · see citing works

Obesity and sex interact in the regulation of Alzheimer's disease

Moser, V. A., & Pike, C. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.021 · Cited by 89 · see citing works

The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders

Dionysopoulou, S., Charmandari, E., Bargiota, Α., Vlahos, N., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020498 · Cited by 88 · see citing works

The impact of obesity and hypercaloric diet consumption on anxiety and emotional behavior across the lifespan

Baker, K., Loughman, A., Spencer, S. J., & Reichelt, A. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.014 · Cited by 86 · see citing works

Hippocampal dysfunctions caused by cranial irradiation: A review of the experimental evidence

Son, Y., Yang, M., Wang, H., & Moon, C. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.007 · Cited by 84 · see citing works

Well-being and immune response: a multi-system perspective

Lasselin, J., Alvarez‐Salas, E., & Grigoleit, J. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.05.003 · Cited by 83 · see citing works

Proteomics, metabolomics and metagenomics for type 2 diabetes and its complications

Wang, N., Zhu, F., Chen, L., & Chen, K. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.035 · Cited by 80 · see citing works

What animal models can tell us about long-term cognitive dysfunction following sepsis: A systematic review

Savi, F. F., de Oliveira, A. L. R., de Medeiros, G. F., Bozza, F. A., Michels, M., Sharshar, T., Dal‐Pizzol, F., & Ritter, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.005 · Cited by 79 · see citing works

The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 83 · see citing works

High fat diet induced-obesity facilitates anxiety-like behaviors due to GABAergic impairment within the dorsomedial hypothalamus in rats

Noronha, S. I. S. R., Campos, G. V., de Abreu, A. R. R., de Souza, A. M. A., Chianca, D. A., & de Menezes, R. C. A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.042 · Cited by 73 · see citing works

The effect of high-fat diet on rat’s mood, feeding behavior and response to stress

Aslani, S., Vieira, N., Marques, F., Costa, P., Sousa, N., & Palha, J. A. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.178 · Cited by 70 · see citing works

High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism

Zilkha, N., Kuperman, Y., & Kimchi, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.070 · Cited by 68 · see citing works

Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice.

de Paiva, I. H. R., Maciel, L. M., da Silva, R. S., Mendonça, I. P., de Souza, J. D., & Peixoto, C. A. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114153 · Cited by 70 · see citing works

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65 · see citing works

Cafeteria-diet effects on cognitive functions, anxiety, fear response and neurogenesis in the juvenile rat

Ferreira, A., Castro, J. P., Andrade, J. P., Madeira, M. D., & Cardoso, A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.07.014 · Cited by 67 · see citing works

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176554 · Cited by 64 · see citing works

Brain-immune crosstalk in the treatment of major depressive disorder

Branchi, I., Poggini, S., Capuron, L., Benedetti, F., Poletti, S., Tamouza, R., Drexhage, H. A., Penninx, B. W. J. H., & Pariante, C. M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.016 · Cited by 64 · see citing works

Towards a “Metabolic” Subtype of Major Depressive Disorder: Shared Pathophysiological Mechanisms May Contribute to Cognitive Dysfunction

Liu, C., Carvalho, A., & McIntyre, R. (2015) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130204031 · Cited by 61 · see citing works

High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain

Sharma, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113528 · Cited by 64 · see citing works

Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease

Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65 · see citing works

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

Baeza‐Flores, G. D. C., Guzmán‐Priego, C. G., Flores, L. I. P., Murbartián, J., Torres‐López, J. E., & Granados‐Soto, V. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.558474 · Cited by 65 · see citing works

Association of high-fat diet with neuroinflammation, anxiety-like defensive behavioral responses, and altered thermoregulatory responses in male rats

Noronha, S. I. S. R., Lima, P. M. A., Campos, G. S. V., Chírico, M. T. T., de Abreu, A. R. R., Figueiredo, A. B., Silva, F. C. S., Chianca, D. A., Lowry, C. A., & de Menezes, R. C. A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.030 · Cited by 60 · see citing works

The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation

Sánchez‐Sarasúa, S., Moustafa, S., García-Avilés, Á., López‐Climent, M. F., Gómez‐Cadenas, ‪., Olucha-Bordonau, F. E., & Sánchez‐Pérez, A. M. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0137-3 · Cited by 59 · see citing works

Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity

Fourrier, C., Bosch‐Bouju, C., Boursereau, R., Sauvant, J., Aubert, A., Capuron, L., Ferreira, G., Layé, S., & Castanon, N. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.316 · Cited by 55 · see citing works

Traumatic brain injury and obesity induce persistent central insulin resistance

Karelina, K., Sarac, B. A., Freeman, L. M., Gaier, K. R., & Weil, Z. M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13194 · Cited by 57 · see citing works

Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation

Wu, H., Lv, W., Pan, Q., Kalavagunta, P. K., Liu, Q., Qin, G., Cai, M., Zhou, L., Wang, T., Xia, Z., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.022 · Cited by 54 · see citing works

Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice

Santos, C. J., Ferreira, A. V. M., de Oliveira, A. L. F., Oliveira, M. C., Gomes, J. S., & de Aguiar, D. C. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1213529 · Cited by 52 · see citing works

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1

Choubey, P., Kwatra, M., Pandey, S. N., Kumar, D., Dwivedi, D. K., Rajput, P., Mishra, A., Lahkar, M., & Jangra, A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5105-3 · Cited by 52 · see citing works

Inducible nitric oxide synthase plays a role in depression- and anxiety-like behaviors chronically induced by lipopolysaccharide in rats: Evidence from inflammation and oxidative stress

Beheshti, F., Hashemzehi, M., Hosseini, M., Marefati, N., & Memarpour, S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112720 · Cited by 52 · see citing works

Saturated high-fat feeding independent of obesity alters hypothalamus-pituitary-adrenal axis function but not anxiety-like behaviour

Hryhorczuk, C., Décarie-Spain, L., Sharma, S., Daneault, C., Rosiers, C. D., Alquier, T., & Fulton, S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.06.002 · Cited by 51 · see citing works

Obesity and Mental Health: A Longitudinal, Cross-Cultural Examination in Germany and China

Lavallee, K. L., Zhang, X. C., Schneider, S., & Margraf, J. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.712567 · Cited by 49 · see citing works

Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress

Zhong, J.-Y., Li, G., Xu, H., Wang, Y., & Shi, M. (2019) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20198434 · Cited by 47 · see citing works

Effect of high-fat diets on mood and learning performance in adolescent mice

Rio, D. D., Morales, L., Ruiz‐Gayo, M., & Olmo, N. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.04.052 · Cited by 46 · see citing works

Neuropeptide VGF C-Terminal Peptide TLQP-62 Alleviates Lipopolysaccharide-Induced Memory Deficits and Anxiety-like and Depression-like Behaviors in Mice: The Role of BDNF/TrkB Signaling

Li, C., Li, M., Yu, H., Shen, X., Wang, J., Sun, X., Wang, Q., & Wang, C. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00154 · Cited by 46 · see citing works

Saturated Fatty Acid Intake Is Associated With Increased Inflammation, Conversion of Kynurenine to Tryptophan, and Delta-9 Desaturase Activity in Healthy Humans

Berg, J., Seyedsadjadi, N., & Grant, R. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920981946 · Cited by 44 · see citing works

The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

Lin, M.-H., Cheng, P.-C., Hsiao, P.-J., Chen, S.-C., Hung, C.-H., Kuo, C.-H., Huang, S.-K., & Clair Chiou, H.-Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109653 · Cited by 42 · see citing works

New insights into the neurobiological mechanisms of major depressive disorders

Fakhoury, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.005 · Cited by 41 · see citing works

Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review

Woo, Y. S., Lim, H. K., Wang, S., & Bahk, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186969 · Cited by 41 · see citing works

Agomelatine effects on fat-enriched diet induced neuroinflammation and depression-like behavior in rats

Rebai, R., Jasmin, L., & Boudah, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111246 · Cited by 40 · see citing works

A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol

Li, S.-W., Yu, H., Sheen, J., Tiao, M., Tain, Y., Lin, I.-C., Lin, Y., Chang, K., Tsai, C., & Huang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.22960 · Cited by 40 · see citing works

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

Hayes, A., Lauer, L. T., Kao, A. E., Sun, S., Klug, M. E., Tsan, L., Rea, J. J., Subramanian, K. S., Gu, C., Tanios, N., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.015 · Cited by 38 · see citing works

Effect of Metformin on Short-Term High-Fat Diet-Induced Weight Gain and Anxiety-Like Behavior and the Gut Microbiota

Ji, S., Wang, L., & Li, L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00704 · Cited by 37 · see citing works

Systemic TNF-α blockade attenuates anxiety and depressive-like behaviors in db/db mice through downregulation of inflammatory signaling in peripheral immune cells

Alshammari, M. A., Khan, M. R., Mahmood, H. M., Alshehri, A. O., Alasmari, F. F., Alqahtani, F., Alasmari, A. F., AlSharari, S. D., Alhossan, A., Ahmad, S. F., et al. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.04.001 · Cited by 37 · see citing works

Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission

de Oliveira, C. M., Pourtau, L., Vancassel, S., Pouchieu, C., Capuron, L., Gaudout, D., & Castanon, N. (2021) · Nutrients · doi:10.3390/nu13030904 · Cited by 38 · see citing works

Sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression and cognitive impairment: The role of pro-inflammatory cytokines and synaptic plasticity-associated proteins

Zhang, Y., Wei, R., Feng, Y.-Z., Zhang, K.-X., Ge, Y.-J., Kong, X.-Y., Li, X., & Chen, G. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578252 · Cited by 35 · see citing works

Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice

Larsson, M. K., Faka, A., Bhat, M., Imbeault, S., Goiny, M., Orhan, F., Oliveros, A., Ståhl, S., Liu, X. C., Choi, D., et al. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1939-4 · Cited by 35 · see citing works

High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner

Yanguas‐Casás, N., Torres‐Fuentes, C., Crespo‐Castrillo, A., Díaz-Pacheco, S., Healy, K., Stanton, C., Chowen, J. A., García‐Segura, L. M., Arévalo, M., Cryan, J. F., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105495 · Cited by 36 · see citing works

Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain

Ghaddar, B., & Diotel, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105372 · Cited by 34 · see citing works

Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus

Glendining, K. A., Higgins, M. B. A., Fisher, L. C., & Jasoni, C. L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.006 · Cited by 32 · see citing works

A YOLO based software for automated detection and analysis of rodent behaviour in the open field arena

Hatton‐Jones, K. M., Christie, C., Griffith, T. A., Smith, A., Naghipour, S., Robertson, K., Russell, J. S., Peart, J. N., Headrick, J. P., Cox, A. J., et al. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104474 · Cited by 32 · see citing works

Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice

Strekalova, T. V., Costa-Nunes, J. P., Veniaminova, E. A., Kubatiev, A. A., Lesch, K., Chekhonin, V. P., Evans, M. C., & Steinbusch, H. W. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.045 · Cited by 31 · see citing works

Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model

Woodie, L. N., Johnson, R. M., Ahmed, B., Fowler, S., Haynes, W., Carmona, B. A., Reed, M. N., Suppiramaniam, V. D., & Greene, M. W. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.053 · Cited by 31 · see citing works

Experimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB/c Mice

Lara-Espinosa, J. V., Santana-Martínez, R. A., Maldonado, P. D., Zetter, M. A., Becerril‐Villanueva, E., Pérez‐Sánchez, G., Pavón, L., Mata‐Espinosa, D., Barrios‐Payán, J., López-Torres, M. O., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249483 · Cited by 31 · see citing works

Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams

Wu, Z., Zhou, L., Sun, L., Xie, Y., Xiao, L., Wang, H., & Wang, G. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.016 · Cited by 31 · see citing works

Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice

Pan, Q., Liu, Q., Wan, R., Kalavagunta, P. K., Liu, L., Lv, W., Qiao, T., Shang, J., & Wu, H. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-0392-x · Cited by 30 · see citing works

Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice

Wang, H., Zhou, J., Liu, Q. Z., Wang, L. L., & Shang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02576-5 · Cited by 29 · see citing works

Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression.

Maher, A. M., Saleh, S. R., Elguindy, N., Hashem, H. M., & Yacout, G. (2020) · Life Science · doi:10.1016/j.lfs.2020.117427 · Cited by 30 · see citing works

A new experimental design to study inflammation-related versus non-inflammation-related depression in mice

Cardinal, P., de Oliveira, C. M., Sauvant, J., Foury, A., Darnaudéry, M., Vancassel, S., Castanon, N., & Capuron, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02330-9 · Cited by 29 · see citing works

Central mechanisms in sympathetic nervous dysregulation in obesity

Patel, M., Braun, J., Lambert, G. W., Kameneva, T., Keatch, C., & Lambert, É. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00254.2023 · Cited by 33 · see citing works

Legend of Weight Loss: A Crosstalk Between the Bariatric Surgery and the Brain

Lin, Z., & Qu, S. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04474-8 · Cited by 28 · see citing works

Access to a high resource environment protects against accelerated maturation following early life stress: A translational animal model of high, medium and low security settings

Strzelewicz, A. R., Sanchez, E. O., Rondón-Ortiz, A. N., Raneri, A., Famularo, S. T., Bangasser, D. A., & Kentner, A. C. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.01.003 · Cited by 28 · see citing works

Pioglitazone Attenuates Lipopolysaccharide-Induced Oxidative Stress, Dopaminergic Neuronal Loss and Neurobehavioral Impairment by Activating Nrf2/ARE/HO-1

Zakaria, A., Rady, M., Mahran, L., & Abou‐Aisha, K. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02907-0 · Cited by 28 · see citing works

Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies

Escobar, A. P., Bonansco, C., Cruz, G., Dagnino‐Subiabre, A., Fuenzalida, M., Negrón-Oyarzo, I., Sotomayor‐Zárate, R., Martínez-Pinto, J., & Jorquera, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210083 · Cited by 29 · see citing works

Body fat and the cognitive pattern: A population-based study

Tikhonoff, V., Casiglia, E., Guidotti, F., Giordano, N., Martini, B., Mazza, A., Spinella, P., & Palatini, P. (2015) · Obesity · doi:10.1002/oby.21114 · Cited by 26 · see citing works

Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

Hasebe, K., Rivera, L. R., Smith, C. M., Allnutt, T. R., Crowley, T. M., Nelson, T. M., Dean, O. M., McGee, S. L., Walder, K. R., & Gray, L. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.001 · Cited by 26 · see citing works

133. Lipopolysaccharide induces the enzyme indoleamine 2,3-dioxygenase in mouse organotypic hippocampal slice cultures

Fu, X., Zunich, S. M., Dantzer, R., & Kelley, K. W. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.136

98. Depressive-like behaviors induced by lipopolysaccharide are associated with increased brain kynurenine metabolism

O’Connor, J. C., Lawson, M. A., Dantzer, R., & Kelley, K. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.06.103

Diet-induced obesity attenuates cytokine production following an immune challenge

Baumgarner, K. M., Setti, S. E., Diaz, C., Littlefield, A. M., Jones, A. C., & Kohman, R. A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.017 · Cited by 27 · see citing works

Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome

Dinel, A., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.014 · Cited by 84 · see citing works

Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in obese and diabetic db/db mice

Castanon, N., Dinel, A., André, C., Aubert, A., & Layé, S. (2013) · HAL