Research progress on the anti-hepatic fibrosis action and mechanism of natural products

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works

The global burden of liver disease: The major impact of China

Wang, F., Fan, J., Zhang, Z., Gao, B., & Wang, H. (2014) · Hepatology · doi:10.1002/hep.27406 · Cited by 1,258 · see citing works

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

Bertola, A., Mathews, S., Ki, S. H., Wang, H., & Gao, B. (2013) · Nature Protocols · doi:10.1038/nprot.2013.032 · Cited by 1,226 · see citing works

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

Xu, F., Liu, C., Zhou, D., & Zhang, L. (2016) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415627681 · Cited by 759 · see citing works

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

Ramirez, T., Li, Y.-M., Yin, S., Xu, M.-J., Feng, D., Zhou, Z., Zang, M., Mukhopadhyay, P., Varga, Z. V., Pacher, P., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.004 · Cited by 186 · see citing works

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

Wang, R., Zhang, H., Wang, Y., Song, F., & Yuan, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.03.029 · Cited by 145 · see citing works

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

Pascoli, M. D., Diví, M., Rodrı́guez-Vilarrupla, A., Rosado, E., Gracia‐Sancho, J., Vilaseca, M., Bosch, J., & García‐Pagán, J. C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.012 · Cited by 136 · see citing works

Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges

Mathews, S., Xu, M., Wang, H., Bertola, A., & Gao, B. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00041.2014 · Cited by 127 · see citing works

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/ mTOR /p70S6K and TGFβ/Smad signalling pathways

Li, J., Li, X., Xu, W., Wang, S., Hu, Z., Zhang, Q., Deng, X., Wang, J., Zhang, J., & Guo, C. (2014) · Liver International · doi:10.1111/liv.12638 · Cited by 126 · see citing works

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

Wu, Y., Liu, X., Zhou, Q. Y., Huang, C., Meng, X., Xu, F., & Li, J. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.09.028 · Cited by 116 · see citing works

Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in wistar rats

Gan, F., Liu, Q., Liu, Y., Huang, D. W., Pan, C., Song, S., & Huang, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.047 · Cited by 113 · see citing works

Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function

Li, R., Xu, L., Liang, T., Li, Y., Zhang, S., & Duan, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.059 · Cited by 111 · see citing works

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Wang, Y., Guan, M., Zhao, X., & Li, X. (2018) · Pharmaceutical Biology · doi:10.1080/13880209.2018.1479868 · Cited by 110 · see citing works

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Yang, F., Luo, L., Zhu, Z., Zhou, X., Wang, Y., Xue, J., Zhang, J., Cai, X., Chen, Z.-L., Ma, Q., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00929 · Cited by 107 · see citing works

Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats

Yan, F., Zhang, Q., Jiao, L., Han, T., Zhang, H., Qin, L., & Khalid, R. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.02.004 · Cited by 106 · see citing works

Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation

Liu, Y., Wen, P., Zhang, X., Dai, Y., & He, Q. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3651 · Cited by 102 · see citing works

Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells

Wang, Q., Dai, X., Yang, W., Wang, H., Zhao, H., Yang, F., Yang, Y., Li, J., & Lv, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.02.012 · Cited by 95 · see citing works

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

Yu, H., Yao, Y., Bu, F., Chen, Y., Wu, Y., Yang, Y., Chen, X., Zhu, Y., Wang, Q., Pan, X., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.01.004 · Cited by 92 · see citing works

Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver

Bian, E., Wang, Y., Yang, Y., Wu, B., Xu, T., Meng, X., Huang, C. Z., Zhang, L., Lv, X., Xiong, Z., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.009 · Cited by 90 · see citing works

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

Hernández‐Aquino, E., Zarco, N., Casas‐Grajales, S., Ramos‐Tovar, E., Flores‐Beltrán, R. E., Arauz, J., Shibayama, M., Favari, L., Tsutsumi, V., Segovia, J., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i24.4354 · Cited by 87 · see citing works

Effect of Fuzheng Huayu formula and its actions against liver fibrosis

Liu, C., Hu, Y., Xu, L., Liu, C., & Liu, P. (2009) · Chinese Medicine · doi:10.1186/1749-8546-4-12 · Cited by 82 · see citing works

Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis

Hsu, Y., Chiu, Y., Cheng, C., Wu, C., Lin, Y., & Huang, Y. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04361.x · Cited by 82 · see citing works

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells

Wang, X., Ikejima, K., Kon, K., Arai, K., Aoyama, T., Okumura, K., Abe, W., Sato, N., & Watanabe, S. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.040 · Cited by 82 · see citing works

Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

Lai, L., Chen, Y., Tian, X., Li, X., Zhang, X., Lei, J., Bi, Y., Fang, B., & Song, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.040 · Cited by 80 · see citing works

Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

Chen, W., Zhang, Z., Yao, Z., Wang, L., Zhang, F., Shao, J., Chen, A., & Zheng, S. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.029 · Cited by 80 · see citing works

Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation

Choi, J. H., Jin, S. W., Choi, C. Y., Kim, H. G., Lee, G. H., Kim, Y.-A., Chung, Y., & Jeong, H. G. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04805 · Cited by 77 · see citing works

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

Baltă, C., Herman, H., Boldura, O. M., Gasca, I., Roșu, M., Ardelean, A., & Hermenean, A. O. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.013 · Cited by 76 · see citing works

Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis

Wang, J., Li, L., Li, L., Qi, Y., Li, J., & Xu, T. (2018) · Gene · doi:10.1016/j.gene.2018.06.053 · Cited by 76 · see citing works

Novel Insights on Notch signaling pathways in liver fibrosis

Ni, M.-M., Wang, Y.-R., Wu, W., Xia, C.-C., Zhang, Y.-H., Xu, J., Xu, T., & Li, J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.02.051 · Cited by 73 · see citing works

Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis

Zhang, L., Liu, C., Meng, X., Huang, C., Xu, F., & Li, J. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2258-1 · Cited by 73 · see citing works

Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats

Ezhilarasan, D., Karthikeyan, S., & Vivekanandan, P. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.07.004 · Cited by 70 · see citing works

Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells

Shu, J.-C., He, Y.-J., Lv, X., Ye, G.-R., & Wang, L. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0347-3 · Cited by 67 · see citing works

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Guo, C., Li, J., Chen, K., Li, S., Feng, J., Liu, T., Wang, F., Zhang, R., Xu, S., Zhou, Y., et al. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s98740 · Cited by 66 · see citing works

Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells

Gu, Y.-J., Sun, W., Zhang, S., Li, X., & Wei, W. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2692 · Cited by 66 · see citing works

Potent natural products and herbal medicines for treating liver fibrosis

Chen, S., Chen, X., Lu, J., Wang, Y., & Wang, Y. (2015) · Chinese Medicine · doi:10.1186/s13020-015-0036-y · Cited by 64 · see citing works

EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis

Yang, Y., Chen, X., Li, W., Wu, X., Huang, C., Xie, J., Zhao, Y., Meng, X., & Li, J. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13153 · Cited by 62 · see citing works

Oxymatrine attenuates CCl 4 -induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways

Zhao, H., Zhang, Z., Chai, X., Li, G.-Q., Cui, H., Wang, H., Meng, Y.-K., Liu, H., Wang, J., Li, R., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.040 · Cited by 62 · see citing works

Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

Zhan, L., Huang, C., Meng, X., Song, Y., Wu, X. Q., Yang, Y., & Li, J. (2014) · Biochimie · doi:10.1016/j.biochi.2014.10.013 · Cited by 61 · see citing works

Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs

Peng, J., Li, X., Feng, Q., Chen, L., Xu, L., & Hu, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213480741 · Cited by 60 · see citing works

Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

Chen, X., Li, W., Chen, Y., Li, X., Li, H.-D., Huang, H., Bu, F., Pan, X., Yang, Y., Huang, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1032-9 · Cited by 58 · see citing works

Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis

Peng, X.-D., Dai, L., Huang, C.-Q., He, C., Yang, B., & Chen, L. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.099 · Cited by 58 · see citing works

Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model

Sang, L., Wang, X., Xu, D.-Y., Sang, L.-X., Han, Y., & Jiang, L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i47.8334 · Cited by 55 · see citing works

Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis

Wang, H., Wu, G. J., Park, H. J., Jiang, P., Sit, W., van Griensven, L. J., & Wan, J. M. (2012) · Chinese Medicine · doi:10.1186/1749-8546-7-23 · Cited by 53 · see citing works

MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/β-catenin pathway

Zhou, D., Wang, X., Wang, Y., Xiang, X.-J., Liang, Z.-C., Zhou, Y., Xu, A., Bi, C.-H., & Zhang, L. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.05.018 · Cited by 53 · see citing works

miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway

Yang, J., Tao, H., Liu, L., Hu, W. M., Deng, Z.-Y., & Li, J. (2016) · Inflammation Research · doi:10.1007/s00011-016-1020-4 · Cited by 52 · see citing works

Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats

Yuan, L., Chen, F., Lü, L., Hu, B., Chen, Z., Li, F., Zhong, M.-M., & Xia, L.-J. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.10.0016 · Cited by 51 · see citing works

DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis

Yang, J., She, Q., Yang, Y., Tao, H., & Li, J. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.07.013 · Cited by 51 · see citing works

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

Li, J., Liu, P., Zhang, R., Cao, L., Qian, H., Liao, J., Xu, W. R., Wu, M., & Yin, Z.-F. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.030 · Cited by 50 · see citing works

Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway

Lin, X., Kong, L., Huang, C., Ma, T., Meng, X., He, Y., Wang, Q., & Li, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.02.009 · Cited by 50 · see citing works

NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis

Xu, T., Ni, M.-M., Xingli, Li, X., Meng, X., Huang, C., & Li, J. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.11.010 · Cited by 49 · see citing works

Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt–β-catenin signaling

Hasan, H. F., Abdel-Rafei, M. K., & Galal, S. M. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0142 · Cited by 49 · see citing works

The role of TRPV4 in fibrosis

Zhan, L., & Li, J. (2017) · Gene · doi:10.1016/j.gene.2017.10.067 · Cited by 49 · see citing works

Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway

Yang, D., Li, L., Qian, S., & Liu, L. (2017) · Journal of Natural Medicines · doi:10.1007/s11418-017-1122-5 · Cited by 48 · see citing works

Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica

Zhang, Y., Huang, D., Gao, W., Yan, J., Zhou, W., Hou, X., Liu, M., Ren, C., Wang, S., & Shen, J. (2015) · International Immunology · doi:10.1093/intimm/dxv017 · Cited by 47 · see citing works

Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride

Tzeng, J., Chen, M., Chung, H., & Cheng, J. (2012) · Phytotherapy Research · doi:10.1002/ptr.4829 · Cited by 47 · see citing works

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

Wu, Y., Bu, F., Yu, H., Li, W., Huang, C., Meng, X., Zhang, L., Ma, T., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.12.002 · Cited by 46 · see citing works

The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice

Geng, Y., Sun, Q., Li, W., Lu, Z., Xu, H., Shi, J., & Xu, Z. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600392 · Cited by 46 · see citing works

Mechanism of collagen resorption in reversible hepatic fibrosis

Hutterer, F., Rubin, E., & Pópper, H. (1964) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(64)90054-1 · Cited by 43 · see citing works

The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation

Wan, Y., Wu, Y., Lian, L., Xie, W.-X., Li, X., Ouyang, B.-Q., Bai, T., Li, Q., Yang, N., & Nan, J. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.01.002 · Cited by 43 · see citing works

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

Li, X., Wu, X., Xu, T., Li, X., Yang, Y., Li, W., Huang, C., Meng, X., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.07.003 · Cited by 43 · see citing works

The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis

Cheng, Y., Tian, Y., Xia, J., Wu, X., Yang, Y., Li, X., Huang, C., Meng, X., Ma, T., & Li, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.01.005 · Cited by 43 · see citing works

γδ T cells in liver diseases

Wang, X., & Tian, Z. (2018) · Frontiers of Medicine · doi:10.1007/s11684-017-0584-x · Cited by 42 · see citing works

Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference

Jiang, Y., Wang, C., Li, Y., Wang, X., An, J.-D., Wang, Y., & Wang, X. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.028 · Cited by 41 · see citing works

Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis

Chen, P., Huang, C., Meng, X., & Li, J. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.016 · Cited by 41 · see citing works

Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1 H NMR analysis

Wu, F., Zheng, H., Yang, Z.-T., Cheng, B., Wu, J., Liu, X.-W., Tang, C., Lu, S., Chen, Z.-N., Song, F., et al. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.03.031 · Cited by 41 · see citing works

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Hicks, D. F., Goossens, N., Blas‐García, A., Tsuchida, T., Wooden, B., Wallace, M. C., Nieto, N., Lade, A. G., Redhead, B., Cederbaum, A. I., et al. (2017) · Scientific Reports · doi:10.1038/srep42563 · Cited by 40 · see citing works

Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling

Wang, L., Yue, Z. D., Guo, M., Fang, L., Bai, L., Li, X., Tao, Y., Wang, S., Liu, Q., Zhi, D., et al. (2016) · BioMed Research International · doi:10.1155/2016/1068528 · Cited by 40 · see citing works

MicroRNA-145 Induces the Senescence of Activated Hepatic Stellate Cells through the Activation of P53 Pathway by ZEB2

Yang, J., Lu, Y., Yang, P., Chen, Q., Wang, Y., Ding, Q., Xu, T., Li, X., Li, C., Huang, C., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27521 · Cited by 40 · see citing works

Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway

Wu, X., Wang, Y., Wang, S., Xu, R., & Lv, X. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2016.12.017 · Cited by 39 · see citing works

Hepatoprotective effects of Dicliptera chinensis polysaccharides on dimethylnitrosamine-induced hepatic fibrosis rats and its underlying mechanism

Zhang, K., Gao, Y., Zhong, M., Xu, Y., Li, J., Chen, Y., Duan, X., & Zhu, H. L. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.053 · Cited by 39 · see citing works

Cucurbitacin‐B attenuates CC l4‐induced hepatic fibrosis in mice through inhibition of STAT ‐3

Sallam, A.-A. M., Esmat, A., & Abdel‐Naim, A. B. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13160 · Cited by 38 · see citing works

Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis

Wang, Q., Wen, R., Lin, Q., Wang, N., Lü, P., & Zhu, X. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3751-4 · Cited by 38 · see citing works

Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway

Kong, R., Wang, N., Luo, H. L., & Lü, J. (2018) · Current Molecular Medicine · doi:10.2174/1566524018666180608084947 · Cited by 37 · see citing works

Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL

Xu, F., Zhou, D., Meng, X., Wang, X., Liu, C., Huang, C., Li, J., & Zhang, L. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.013 · Cited by 36 · see citing works

ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKβ/ERK signaling pathway

Wang, Y.-H., Sun, Y., Zuo, L., Wang, Y., & Huang, Y. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.10.003 · Cited by 36 · see citing works

Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis

Li, J., Li­, ­., Li, S., He, B., Mi, Y., Cao, H., Zhang, C., & Li, L. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.07.019 · Cited by 36 · see citing works

Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells

Wang, N., Xu, Q., Tan, H. Y., Hong, M., Li, S., Yuen, M., & Feng, Y. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/8762345 · Cited by 36 · see citing works

DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis

Pan, X., Yang, Y., Meng, H., Li, H.-D., Chen, X., Huang, H., Bu, F., Yu, H., Wang, Q., Huang, C., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00553 · Cited by 36 · see citing works

Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis

Dong, S., Cai, F., Chen, Q., Song, Y., Sun, Y., Wei, B., Li, X., Hu, Y., Liu, P., & Su, S.-B. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.150 · Cited by 35 · see citing works

Melatonin Ameliorates Liver Fibrosis Induced by Carbon Tetrachloride in Rats via Inhibiting TGF-β1/Smad Signaling Pathway

Wang, Y., Hong, R.-T., Xie, Y., & Xu, J.-M. (2018) · Current Medical Science · doi:10.1007/s11596-018-1871-8 · Cited by 35 · see citing works

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

Lin, L., Zhou, F., Shen, S., & Zhang, T. (2018) · Planta Medica · doi:10.1055/a-0757-0008 · Cited by 34 · see citing works

Exosomal miRNAs as Biomarkers in the Diagnosis of Liver Disease

Wang, S., Wang, J., & Lv, X. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0011 · Cited by 33 · see citing works

Role of NLRC5 in progression and reversal of hepatic fibrosis

Liu, X., Wu, Y., Yang, Y., Li, W., Huang, C., Meng, X., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.01.012 · Cited by 32 · see citing works

Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway

Li, W., Chen, X., Yang, Y., Huang, H., Li, H.-D., Huang, C., Meng, X., & Li, J. (2016) · Toxicology · doi:10.1016/j.tox.2016.11.004 · Cited by 32 · see citing works

Potential protective effects of a traditional Chinese herb, Litsea coreana Levl., on liver fibrosis in rats

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Paeoniflorin exerts protective effect on radiation-induced hepatic fibrosis in rats via TGF-β1/Smads signaling pathway.

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Adjuvant therapy with Jianpi Huayu decoction improves overall and recurrence-free survival after hepatectomy for hepatocellular carcinoma: a retrospective propensity score-matching study

Luo, R., Fang, C., Chen, C., Zhang, Y., Yao, R., Wang, J., Shi, H., Feng, K.-L., Hu, M., & Zhong, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1212116 · Cited by 10 · see citing works

Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway

He, X.-Y., Xiong, X.-J., Liu, M., Liang, J., Liu, F., Xiao, J.-Y., & Wu, L. (2024) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-024-3801-x · Cited by 9 · see citing works

Tandem mass tag-based proteomics analysis reveals the multitarget mechanisms of Phyllanthus emblica against liver fibrosis

Gong, P., Yin, K., Luo, X., Gu, J., Tan, R., Wu, Y., & Li, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.989995 · Cited by 9 · see citing works

Cell-based 3D bionic screening by mimicking the drug–receptor interaction environment in vivo

Wei, F., Zhang, X., Cui, P., Gou, X., & Wang, S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02661a · Cited by 9 · see citing works

The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway

Liu, D., Yang, K., Li, T., Tang, T., Wang, Y., Wang, W., Li, J., Zhou, P., Wang, X., Zhao, C., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34214 · Cited by 8 · see citing works

Selenomethionine Attenuates Aflatoxin B 1 -induced Liver Injury by Modulating the Gut Microbiota and Metabolites in Rabbits

Kong, D., Xu, J., Zhang, Q., Luo, D., Lv, Q., Li, S., Chen, X., Wei, L., Zhu, X., Liu, Y., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c09084 · Cited by 8 · see citing works

Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co‐Inhibition of TGF ‐β and GSK ‐3 Signalling

Zhu, X., Zhong, Z., Du, J., Zhang, J., Zhang, X., Cui, X., Guan, L., Hu, Y., Chen, C., Wang, H., et al. (2025) · Liver International · doi:10.1111/liv.70187 · Cited by 8 · see citing works

Exploration of potential mechanism of Rougan formula against hepatic fibrosis by network analysis and experimental assessment

Wang, W., Zhang, Y., Jiang, Y., Wang, Y., Zhu, J., Wang, C., Han, X., & Wang, J. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115960 · Cited by 8 · see citing works

Ba-Qi-Rougan formula alleviates hepatic fibrosis by suppressing hepatic stellate cell activation via the MSMP/CCR2/PI3K pathway

Xue, Y., Zhu, W., Qiao, F., Yang, Y., Qiu, J., Zou, C., Gao, Y., Zhang, X., Li, M., Shang, Z., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118169 · Cited by 8 · see citing works

A meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy

Ye, Z., Huang, Q., She, Y., Hu, Y., Wu, M., Qin, K., Li, L., Zhang, C., Zuo, X., Wei, A., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.920062 · Cited by 7 · see citing works

Kinetin inhibits hepatic stellate cell activation and induces apoptosis via interactions with the TGF-β1/Smad signaling pathway

Jin, F.-C., Chen, J., Xu, Q.-X., Zhou, M.-H., Lin, Y., Zhang, Q.-W., Zhang, C., & Zhang, Z. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116655 · Cited by 7 · see citing works

Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis

Yu, S., Pu, J., Liu, K., He, C., Yang, F., Chen, K., Yang, X., Zhu, Y., Jiang, J., Luo, M., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1636538 · Cited by 6 · see citing works

Hydrolysable tannins as a potential therapeutic drug for the human fibrosis‐associated disease

Wang, M., & Cao, L. (2023) · Drug development research (Print) · doi:10.1002/ddr.22089 · Cited by 7 · see citing works

Systematic screening of hepatoprotective components from traditional Chinese medicine: Zuojin Pill as an example

Wang, D., Wang, X., Gu, X., Zhang, Y. X., Jiang, Y., Liu, Y., & Di, X. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117556 · Cited by 6 · see citing works

Unveiling the molecular mechanisms of bioactive peptides from Mauremys mutica turtle shell glue in the treatment of liver cancer through network pharmacology integrated with experimental validation

Zhao, T., Yu, M., Zhang, L., Liu, W., Huang, Q., Huang, L., Zhang, Y., & Nan, H. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2023.100949 · Cited by 5 · see citing works

Enhanced anti-inflammatory and anti-fibrotic effects of nanoparticles loaded with a combination of Aloe vera – Moringa oleifera extracts

Carballo-López, G. I., Ojeda-González, J., Martínez-García, K. D., Cervantes-Luévano, K., Moreno‐Ulloa, A., & Castro-Ceseña, A. B. (2024) · Molecular Omics · doi:10.1039/d4mo00195h · Cited by 5 · see citing works

Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance

Xue, W., Liu, H., Su, Z., Wang, S., Cheng, J., Pan, Y., & Zhang, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1525914 · Cited by 5 · see citing works

Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells

Li, W., Lv, R., Zou, T., & Chen, M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122798 · Cited by 5 · see citing works

The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention

Yu, Y., Fang, J., Li, Y., Wang, X., Zhang, J., Wang, J., & Sun, B. (2025) · Nutrients · doi:10.3390/nu17010197 · Cited by 4 · see citing works

Ameliorative efficacy of Syzygium aromaticum ethanolic extract and Silymarin® upon carbon tetrachloride-induced liver fibrosis: antioxidant, antibacterial and anti-inflammatory activities

El‐Fakharany, E. M., El-Sayed, M. H., Ali, H. M., Omar, S. M., Sayed, A. M., Atwa, A. M., Alfaifi, M. Y., Shati, A. A., Elbehairi, S. E. I., Alrayes, Z. R., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-03100-w · Cited by 4 · see citing works

Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate liver fibrosis via micro-7045-5p

Liu, Z., Jiang, X., You, H., Tang, Z., Ma, Y., Che, N., Liu, W., & Ma, C. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05152-4 · Cited by 4 · see citing works

Inhibitory effects of umbelliferone on carbon tetrachloride-induced hepatic fibrosis in rats through the TGF‑β1‑Smad signaling pathway

Liang, L., Dong, Z., Shen, Z., Zang, Y., Yang, W., Wu, L., & Bao, L. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13536 · Cited by 4 · see citing works

The gut microbe Bacteroides acidifaciens ameliorates CCl4-induced liver fibrosis

Ye, F., Hou, Y., Huang, M., Guo, Y., Ye, Y., Liu, Y., Zou, L., Bao, Y., Yuan, R., Zhu, F., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178265 · Cited by 4 · see citing works

Integrated analysis of differentially expressed genes, differentially methylated genes, and natural compounds in hepatitis C virus-induced cirrhosis

Cheng, J., Chen, Z., Zuo, G., & Cao, W. (2022) · Journal of International Medical Research · doi:10.1177/03000605221074525 · Cited by 4 · see citing works

Effects of salvianolic acid B on liver fibrosis

Ma, X., Tang, M., Lu, L., Zheng, J., Huang, J., Li, J., & Luo, W. (2020) · Medicine · doi:10.1097/md.0000000000021036 · Cited by 4 · see citing works

Role of miRNA signalling in the pathogenesis of MASLD

Cheng, S.-L., Hao, J.-S., & Qin, H.-Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1756805 · Cited by 3 · see citing works

Enhanced In Vitro Efficacy of Verbascoside in Suppressing Hepatic Stellate Cell Activation via ROS Scavenging with Reverse Microemulsion

Xiao, X., Yang, F., Huang, Y., Liu, S., Hu, Z., Liao, S., & Li, Y. (2024) · Antioxidants · doi:10.3390/antiox13080907 · Cited by 3 · see citing works

The anti-hepatic fibrosis effects of chlorogenic acid extracted from Artemisia Capillaris Herba on CCl4-induced mice via regulating TGF-β1/smad3 pathway

Huang, L., Xu, Y., Lai, Z., Zhou, Z., & Deng, M. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100227 · Cited by 3 · see citing works

Metabonomic analysis of the anti-hepatic fibrosis effect of Ganlong capsules

Lv, C., Li, Y., Ou, L., Zhou, J., Peng, F., & Wu, D. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122118 · Cited by 3 · see citing works

Oleocanthalic acid improves MASH features via a NOX1-dependent mechanism

Frión-Herrera, Y., Zanotto, I., Colognesi, M., Signor, A., Cuffaro, D., Chilin, A., Macchia, M., Marzaro, G., Digiacomo, M., Gabbia, D., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177847 · Cited by 3 · see citing works

Research progress of natural products interfering with cell signaling pathway in liver fibrosis

Qin, L.-J., Zhang, L., Zheng, Z., & Zhong, X.-H. (2021) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2021.1883003 · Cited by 2 · see citing works

Advancements in traditional Chinese medicine: Harnessing natural products for liver disease through autophagy modulation

Wen, J., Xiang, Q., Chen, Y., Hu, T., Ma, X., Huang, Y., & Rao, C. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110565 · Cited by 2 · see citing works

Treatment strategies and prospects for hepatic fibrosis: Application of traditional Chinese medicine polysaccharides in modulating of the TGF-β1/Smad pathway

Guo, Y.-F., Ying, L., Zhang, H., Wang, M.-Y., Yang, D., & Liu, W. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121988 · Cited by 2 · see citing works

Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

Zhao, J., Tian, X., Zhang, J., Huang, C., Sun, Y., Qiao, S., & Jiang, S. (2023) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-023-3706-0 · Cited by 2 · see citing works

Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review

Arraes, D. R. D. S., Rodrigues, A. B. L., Sanches, P. R., Costa-Campos, C. E., de Almeida, S. S. M. D. S., Lima, J. R. F., Lima, J. D., & Araújo‐Silva, G. (2023) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2023.2270408 · Cited by 2 · see citing works

Tadehaginoside improves liver fibrosis in mice by inhibiting the activation of hepatic stellate cells mediated by the molecular axis of miR-155/FOXO3

Tang, A., Wei, L., Gao, J., Zhang, Z., Xia, B., Li, X., & Lu, Q. (2025) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2527178 · Cited by 1 · see citing works

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis

Zhu, M., Yang, X., Xie, J., Shi, X., Li, J., Shi, Y., Zhang, L., Tian, X., Li, Y., Yao, J., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179110 · Cited by 1 · see citing works

LOC102553417 silencing facilitates the apoptosis of hepatic stellate cells via the miR‑30e/MTDH axis

Wei, W., Lin, C., Hu, R., Huang, J., Chen, X., Zhou, L., Wei, J., Deng, Y., & Wang, C. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12865 · Cited by 1 · see citing works

Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and in vitro Experiments to Explore the Mechanism of Asiatic Acid Inhibiting Acetaldehyde-Induced Activation of Hepatic Stellate Cells

Jiang, T., Chen, X., Yang, W., Li, N., Xu, J., Yang, L., Zhang, S., Yu, S., & Li, Y. (2023) · Natural Product Communications · doi:10.1177/1934578x231194127 · Cited by 1 · see citing works

Clinical study on the efficacy of self-designed elimination soup in the accumulation of qi stagnation and blood stasis based on transient elasticity of liver and spleen

Huang, X., Xu, L., Li, Y., Mingyue, S. O. N. G., & Dongwang, Z. H. A. N. (2023) · Minerva Medica · doi:10.23736/s0026-4806.23.08787-6

Role of Lifestyle Changes and Natural Herbs in the Management of Hepatic Health

Singh, A., Mazumder, A., Das, S., & Kanda, A. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/34070

Ultrastructural Studies on The Protective Effect of The Blue Green Alga (Aphanizomenon flos-aquae) Against Carbon Tetrachloride-Induced Hepatotoxicity in Mice

El-Hameed, D. A. (2023) · Egyptian Journal of Aquatic Biology and Fisheries · doi:10.21608/ejabf.2023.318808

A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

Pan, X., Ma, X., Jiang, Y., Wen, J., Yang, L., Chen, D., Cao, X., & Peng, C. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/7171498 · Cited by 52 · see citing works

Research Progress in Natural Products against Liver Fibrosis

Zhao, S., Chen, X., Tan, R., Xiao-qing, W., & Jiang, H. (2024) · The Natural Products Journal · doi:10.2174/0122103155293866240522085229

Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis

Li, W., Liu, W., Qian, D., Liu, J., Zhou, S.-Q., Zhang, L., Peng, W., Su, L., & Zhang, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.962525 · Cited by 29 · see citing works

A comprehensive review of natural products to fight liver fibrosis: Alkaloids, terpenoids, glycosides, coumarins and other compounds

Ma, X., Jiang, Y., Wen, J., Zhao, Y., Zeng, J., & Guo, Y. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173578 · Cited by 41 · see citing works

Natural drugs modulate MAPK: targets and strategies for liver fibrosis treatment

Luan, Q., Wang, J., Kong, W., & Guo, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1792301 · Cited by 2 · see citing works