The DOI matches its Crossref record; 112 of the 115 references it cites were found in a registry or an index.
Research progress on the anti-hepatic fibrosis action and mechanism of natural products
Abstract
Hepatic fibrosis is the most common pathological feature of most chronic liver diseases, and its continuous deterioration gradually develops into liver cirrhosis and eventually leads to liver cancer. At present, there are many kinds of drugs used to treat liver fibrosis. However, Western drugs tend to only target single genes/proteins and induce many adverse reactions. Most of the mechanisms and active ingredients of traditional Chinese medicine (TCM) are not clear, and there is a lack of unified diagnosis and treatment standards. Natural products, which are characterized by structural diversity, low toxicity, and origination from a wide range of sources, have unique advantages and great potential in anti-liver fibrosis. This article summarizes the work done over the previous decade, on the active ingredients in natural products that are reported to have anti-hepatic fibrosis effects. The effective anti-hepatic fibrosis ingredients identified can be generally divided into flavonoids, saponins, polysaccharides and alkaloids. Mechanisms of anti-liver fibrosis include inhibition of liver inflammation, anti-lipid peroxidation injury, inhibition of the activation and proliferation of hepatic stellate cells (HSCs), modulation of the synthesis and secretion of pro-fibrosis factors, and regulation of the synthesis and degradation of the extracellular matrix (ECM). This review provides suggestions for the development of anti-hepatic fibrosis drugs.
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“In advanced liver fibrosis (LF), macrophages maintain the inflammatory environment in the liver and accelerate LF deterioration by secreting proinflammatory cytokines.”
From An Autologous Macrophage‐Based Phenotypic Transformation‐Collagen Degradation System Treating Advanced Liver Fibrosis (2024) · cites this paper as [11]
In the citing paper
“Macrophages, especially bone marrow macrophages that are recruited to the liver during inflammation, act a central role in the secretion of inflammatory cytokines.[ 11 ]”
From An Autologous Macrophage‐Based Phenotypic Transformation‐Collagen Degradation System Treating Advanced Liver Fibrosis (2024) · cites this paper as [11]
Citations
Cites
1 retracted
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Items 101–111 of 111
Wu, X., Guan, Y., Wang, J., Song, L., Zhang, Y., Wang, Y., Li, Y., Qin, L., He, Q., Zhang, T., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4612978
Research Progress in Natural Products against Liver Fibrosis
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Advances in the Use of Traditional Chinese Medicine in Hepatic Fibrosis Treatment
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Oxymatrine: Hepatoprotective Effects of a Multitarget Natural Alkaloid
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Metadata
- Authors
- Shan, L., Liu, Z., Ci, L., Shuai, C., Lv, X., & Li, J.
- Affiliations
- Anhui Medical University (CN)
- Corresponding author
- Lv, Xiongwen
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 75
- Pages
- 105765
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2963885368
- Cited by
- 111
- References
- 115
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 7 · 2020: 6 · 2019: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81270498)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Keywords
- liver fibrosis, traditional Chinese medicine, flavonoids, saponins, polysaccharides, alkaloids, liver inflammation, lipid peroxidation, hepatic stellate cells, extracellular matrix, liver cirrhosis, drug development
- MeSH terms
- Animals, Biological Products, Humans, Liver Cirrhosis
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