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Cited by 18Natural Compounds in Disease TreatmentRheumatoid Arthritis Research and TherapiesVagus Nerve Stimulation Research

Cholinergic system is involved in the therapeutic effect of madecassoside on collagen-induced arthritis in rats

Dou, Yannong, Luo, Jinque, Yu, Juntao, Xia, Yufeng, Dai, Yue·2019·International Immunopharmacology
DOI 10.1016/j.intimp.2019.105813
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Abstract

Our previous studies demonstrated that oral administration of madecassoside could markedly attenuate collagen-induced arthritis in rats, a rodent model of rheumatoid arthritis. As the autonomic nervous system is critically involved in the modulation of peripheral inflammation and immune response, the present study aims to explore the possible involvement of adrenergic and cholinergic nerves in the effect of madecassoside on rheumatoid arthritis. Arthritis was induced by chicken collagen in rats, and madecassoside was orally administered daily for two weeks from day 14 after the primary immunization. The antagonists of adrenoceptor and cholinergic receptors were co-administered with madecassoside, respectively. Unilateral cervical vagotomy was performed four days before the arthritis induction. The results showed that madecassoside (30 mg/kg) treatment markedly ameliorated arthritis symptoms in rats, mainly evidenced by the reduction of paw swelling and arthritis index scores. Co-administration of madecassoside with atropine (an antagonist of the muscarinic acetylcholine receptor) or hexamethonium (an antagonist of the nicotinic acetylcholine receptor) markedly diminished the therapeutic effects of madecassoside in arthritis. However, co-administration with phentolamine (an antagonist of the α-adrenoceptor) or propranolol (an antagonist of the β-adrenoceptor) did not alter the effect of madecassoside on arthritis. Furthermore, unilateral cervical vagotomy significantly reduced…

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  • Multiple studies verify role of orally administered madecassoside in protecting against arthritis by inhibiting pro-inflammatory cytokines and upregulating anti-inflammatory ones.

    “Furthermore, multiple studies verify the role of orally administered madecassoside in protecting against arthritis by similar action of inhibiting pro‐inflammatory cytokines and upregulating anti‐inflammatory ones.”

    From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [136]

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Authors
Dou, Y., Luo, J., Yu, J., Xia, Y., & Dai, Y.
Affiliations
China Pharmaceutical University (CN)
Corresponding author
  • Xia, Yufeng
  • Dai, Yue
ORCID
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2019-10
Volume
75
Pages
105813
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2019.105813
OpenAlex
W2968912104
Cited by
18
References
5
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81173631, CPU2018GY10)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
madecassoside, collagen-induced arthritis, rheumatoid arthritis, cholinergic system, muscarinic receptors, nicotinic acetylcholine receptors, vagotomy, adrenergic receptors, inflammatory cytokines, anti-inflammatory activity, herbal medicine
MeSH terms
Administration, Oral, Animals, Anti-Inflammatory Agents, Arthritis, Experimental, Female, Knee Joint, Triterpenes, Vagotomy, Vagus Nerve, Cytokines, Rats, Wistar

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