Madecassoside Isolated from Centella asiatica Herbs Facilitates Burn Wound Healing in Mice
Abstract
The current study was designed to investigate the effect of madecassoside, the major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in a time-dependent manner and reached its peak effect, nearly completely wound closure, on day 20 in the group receiving the highest dose of 24 mg/kg of madecassoside. Further histopathological analysis revealed that madecassoside alleviated infiltration of inflammatory cells as well as enhanced epithelisation resulting from dermal proliferation of fibroblasts. Madecassoside at higher doses (12 and 24 mg/kg) decreased nitric oxide (NO) levels and malondialdehyde (MDA) content in the burn skin tissue. However, reduced glutathione (GSH) and hydroxyproline levels were increased in the same skin tissue. In addition, madecassoside promoted skin angiogenesis IN VIVO, correlating with our findings IN VITRO that it stimulated endothelial cell growth in a rat aortic ring assay. These data suggest that madecassoside has significant wound-healing activity and is one of the major reasons for the use of C. ASIATICA herbs in the successful treatment of burn injury. Moreover, the results from the present study indicate that the effect of madecassoside on wound healing may involve several mechanisms including antioxidative activity, collagen synthesis and angiogenesis.
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Enhancement of wound healing, particularly angiogenesis, might be due to stimulation of collagen I and increased production of FGF and VEGF, via activation of the TβR2 kinase-independent pathway.
“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [30]
Madecassoside has significant wound-healing activity based on mechanisms including anti-inflammatory and antioxidative activity, collagen synthesis and angiogenesis.
“Madecassoside has significant wound‐healing activity based on several mechanisms including anti‐inflammatory and antioxidative activity, collagen synthesis and angiogenesis”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [100]
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Bakshi, I. S., Chopra, H., Sharma, M., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824385-5.00003-0 · Cited by 13 · see citing works
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Nurturing hope: Uncovering the potential of herbal remedies against amyotrophic lateral sclerosis
Gupta, M., Hussain, M. S., Thapa, R., Bhat, A. A., & Kumar, N. (2024) · PharmaNutrition · doi:10.1016/j.phanu.2024.100406 · Cited by 10 · see citing works
Mechanisms of Sensitive Skin and the Soothing Effects of Active Compounds: A Review
Chen, B., Tang, H., Liu, Z., Qiao, K., Chen, X., Liu, S., Pan, N., Chen, T., & Liu, Z. (2024) · Cosmetics · doi:10.3390/cosmetics11060190 · Cited by 14 · see citing works
., A. I. C. D., Peter, G., Jude, S., Arundhathy, C. A., Jacob, J., Amalraj, A., Pius, A., & Gopi, S. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2017.1280681 · Cited by 10 · see citing works
“Asiaticoside (C48H78O19) was reported to induce changes in the expression of genes responsible for the synthesis of type-I collagen in human fibroblasts,([13,14]) whereas madecassoside (C48H78O20), possess a significant antirheumatoid effect, wound-healing properties, antiaging, and anticancer properties.([15,16]) Sev…”
BackgroundGang, R., Okello, D., & Kang, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29717 · Cited by 11 · see citing works
“Reported mechanisms of action through which these medicinal plants exerted their wound healing activities comprise anti-oxidative activities [96 – 99], anti-inflammatory and immunomodulatory effects [100 – 103], antimicrobial effects [104 – 107], collagen synthesis [95,101,108], cell proliferation…”
BackgroundEvaluation of the cutaneous wound healing potential of tamanu oil in wounds induced in rats
Erdoğan, S. S., Gür, T. F., Terzi, N. K., & Doğan, B. (2021) · Journal of Wound Care · doi:10.12968/jowc.2021.30.sup9a.v · Cited by 8 · see citing works
Triterpenoid Centellosides: Bioactivities and Uses in Healthcare Application
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“Oral intake of MA, the major triterpenoid centelloside of CA, at 6, 12, and 24 mg kg 1 was seen to speed up the healing of burn wound in a timedependent manner due to the involvement of several mechanisms such as antioxidative activity, collagen synthesis, and angiogenesis [35].”
BackgroundProangiogenic Potential of Medicinal Plants in Wound Healing
Kasote, D. M., Ahmad, A., & Viljoen, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800874-4.00006-4 · Cited by 9 · see citing works
Centella Asiatica Extract Containing Bilayered Electrospun Wound Dressing
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Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression
Lee, S., Ye, S., Kim, M., Lee, H., Jun, S., & Kang, N. G. (2024) · Biomolecules · doi:10.3390/biom14030279 · Cited by 7 · see citing works
“Because several studies reported the role of madecassoside in fibroblasts [49,50], excellent efficacy was expected; however, we found that its treatment did not result in a statistically significant increase in gene expression (Figure 4c).”
BackgroundNovel Approaches for the Application of Herbs for Skin Care
Gautam, R. K., Kamal, M. A., Chopra, H., Tsagkaris, C., & Matthews, L. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666220411110358 · Cited by 7 · see citing works
Aktivitas pegagan (Centella asiatica) pada dermatologi
Fernenda, L., Ramadani, A. P., & Syukri, Y. (2023) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.9.3.237-244.2022 · Cited by 7 · see citing works
Galli, V., D’Augè, T. G., Pierro, F. D., et al. (2024) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.23.05409-x · Cited by 6 · see citing works
Noppradit, B., Klinnawee, L., Leeratiwong, C., Praparatana, R., & Puttarak, P. (2024) · Phytochemical Analysis · doi:10.1002/pca.3371 · Cited by 6 · see citing works
New Insights in Psoriasis Management using Herbal Drug Nanocarriers
Salgaonkar, S. P., Purewal, J. S., Doshi, G., Fernandes, T., Gharat, S., & Sawarkar, S. P. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128330298240708110336 · Cited by 6 · see citing works
- Authors
- Liu, M., Dai, Y., Li, Y., Luo, Y., Huang, F., Gong, Z., & Meng, Q.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing Normal University (CN)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2008-06
- Volume
- 74
- Issue
- 08
- Pages
- 809-815
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1989354404
- Cited by
- 142
- References
- 0
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 20 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- madecassoside, Centella asiatica, burn wound healing, triterpenoids, angiogenesis, re-epithelialization, fibroblast proliferation, oxidative stress, antioxidant activity, collagen synthesis, nitric oxide, malondialdehyde, reduced glutathione, hydroxyproline, endothelial cell growth, anti-inflammatory activity
- MeSH terms
- Animals, Burns, Collagen, Male, Phytotherapy, Mice, Inbred ICR, Triterpenes, Wound Healing, Lipid Peroxidation, Neovascularization, Physiologic, Centella, Mice
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