The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2

NAFLD: A multisystem disease

Byrne, C. D., & Targher, G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.12.012 · Cited by 3,082 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

Pawlak, M., Lefebvre, P., & Staels, B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.039 · Cited by 1,578 · see citing works

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Samuel, V. T., & Shulman, G. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci77812 · Cited by 1,484 · see citing works

PPAR control of metabolism and cardiovascular functions

Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 960 · see citing works

Advancing the global public health agenda for NAFLD: a consensus statement

Lazarus, J. V., Mark, H. E., Anstee, Q. M., Arab, J. P., Batterham, R. L., Castera, L., Cortez-Pinto, H., Crespo, J., Cusi, K., Dirac, M. A., et al. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00523-4 · Cited by 757 · see citing works

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses

Christofides, A., Konstantinidou, E., Jani, C., & Boussiotis, V. (2020) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2020.154338 · Cited by 654 · see citing works

Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex

Fujihara, M., Muroi, M., Tanamoto, K., Suzuki, T., Azuma, H., & Ikeda, H. (2003) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.08.003 · Cited by 573 · see citing works

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

Tilg, H., Adolph, T., Dudek, M., & Knolle, P. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00501-9 · Cited by 495 · see citing works

NAFLD: Mechanisms, Treatments, and Biomarkers

Nassir, F. (2022) · Biomolecules · doi:10.3390/biom12060824 · Cited by 422 · see citing works

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

Luo, R., Su, L.-Y., Li, G., Yang, J., Liu, Q., Yang, L.-X., Zhang, D.-F., Zhou, H., Xu, M., Fan, Y., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1596488 · Cited by 364 · see citing works

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

Zhang, Y.-S., Liang, X., Bao, X., Xiao, W., & Chen, G. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114291 · Cited by 306 · see citing works

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

Wang, Y., Qian, Y., Fang, Q., Zhong, P., Li, W., Wang, L., Fu, W., Zhang, Y., Xu, Z., Li, X., et al. (2017) · Nature Communications · doi:10.1038/ncomms13997 · Cited by 267 · see citing works

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

Rosa, S. C. D. S., Nayak, N., Caymo, A. M., & Gordon, J. W. (2020) · Physiological Reports · doi:10.14814/phy2.14607 · Cited by 251 · see citing works

Natural history of metabolic dysfunction-associated steatotic liver disease

Lekakis, V., & Papatheodoridis, G. (2023) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2023.11.005 · Cited by 243 · see citing works

Nonalcoholic Fatty Liver Disease: Focus on Lipoprotein and Lipid Deregulation

Tacer, K. F., & Rozman, D. (2011) · Journal of Lipids · doi:10.1155/2011/783976 · Cited by 232 · see citing works

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

Csák, T., Velayudham, A., Hritz, I., Petrášek, J., Levin, I., Lippai, D., Catalano, D. E., Mandrekar, P., Dolganiuc, A., Kurt‐Jones, E. A., et al. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00163.2009 · Cited by 229 · see citing works

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Liu, Q., Bengmark, S., & Qu, S. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-42 · Cited by 227 · see citing works

Cardiac Alpha1-Adrenergic Receptors: Novel Aspects of Expression, Signaling Mechanisms, Physiologic Function, and Clinical Importance

O’Connell, T. D., Jensen, B. C., Baker, A. J., & Simpson, P. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007203 · Cited by 205 · see citing works

Muscle and adipose tissue insulin resistance: malady without mechanism?

Fazakerley, D. J., Krycer, J. R., Kearney, A. L., HOCKING, S. L., & James, D. E. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r087510 · Cited by 181 · see citing works

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

Chandra, S., Roy, A., Jana, M., & Pahan, K. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.007 · Cited by 149 · see citing works

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

Wang, Y., Luo, W., Han, J., Khan, Z. A., Fang, Q., Jin, Y., Chen, X., Zhang, Y., Wang, M., Qian, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15978-3 · Cited by 148 · see citing works

USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart

Xie, S., Liu, S., Zhang, T., Shi, W., Xing, Y., Fang, W., Zhang, M., Chen, M.-Y., Xu, S., Fan, M.-Q., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.065603 · Cited by 143 · see citing works

Proceedings of the 2024 6th International Conference on Structural Seismic and Civil Engineering Research (ICSSCER 2024)

(2024) · Advances in engineering research/Advances in Engineering Research · doi:10.2991/978-94-6463-556-0 · Cited by 131 · see citing works

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

Qu, C., Zheng, D., Li, S., Liu, Y., Lidofsky, A., Holmes, J. A., Chen, J., He, L., Wei, L., Liao, Y., et al. (2018) · Hepatology · doi:10.1002/hep.29881 · Cited by 106 · see citing works

Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2

Bai, Y., Min, R., Chen, P., Mei, S., Deng, F., Zheng, Z., Jiang, C., Miao, R., Wu, Z., Zhang, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306399120 · Cited by 64 · see citing works

Inhibition of myeloid differentiation factor 2 by baicalein protects against acute lung injury

Chen, H., Zhang, Y., Zhang, W., Liu, H., Sun, C., Zhang, B., Bai, B., Wu, D., Xiao, Z., Lum, H., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152997 · Cited by 57 · see citing works

Innate Immunity and MASLD

Meyer, M., Schwärzler, J., Jukic, A., & Tilg, H. (2024) · Biomolecules · doi:10.3390/biom14040476 · Cited by 50 · see citing works

High-Fat Diet-Induced Renal Proximal Tubular Inflammatory Injury: Emerging Risk Factor of Chronic Kidney Disease

Chen, S., Chen, J., Li, S., Guo, F., Li, A., Wu, H., Chen, J., Pan, Q., Liao, S., Liu, J., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.786599 · Cited by 44 · see citing works

Pattern-recognition receptors: signaling pathways and dysregulation in canine chronic enteropathies—brief review

Heilmann, R. M., & Allenspach, K. (2017) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638717728545 · Cited by 39 · see citing works

Licochalcone A protects against LPS‐induced inflammation and acute lung injury by directly binding with myeloid differentiation factor 2 (MD2)

Zhu, W., Wang, M., Jin, L., Yang, B., Bai, B., Mutsinze, R. N., Zuo, W., Chattipakorn, N., Huh, J. Y., Liang, G., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15999 · Cited by 31 · see citing works

Inhibition of MD2‐dependent inflammation attenuates the progression of non‐alcoholic fatty liver disease

Zhang, Y., Wu, B., Zhang, H., Ge, X., Ying, S., Hu, M., Li, W., Huang, Y., Wang, L., Chen, C., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13395 · Cited by 29 · see citing works

MD2 deficiency prevents high‐fat diet‐induced AMPK suppression and lipid accumulation through regulating TBK1 in non‐alcoholic fatty liver disease

Luo, W., Lin, Y., Hu, X., Wang, M., Wang, M., Jin, L., Xiao, Z., Qian, J., Wang, Y., Zuo, W., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.777 · Cited by 24 · see citing works

Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis

Fang, Q., Wang, J., Zhang, Y., Wang, L., Li, W., Han, J., Huang, W., Liang, G., & Wang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.026 · Cited by 21 · see citing works

Acertannin Attenuates LPS-Induced Inflammation by Interrupting the Binding of LPS to the TLR4/MD2 Complex and Activating Nrf2-Mediated HO-1 Activation

Molagoda, I. M. N., Karunarathne, W. A. H. M., Lee, M., Kang, C.-H., Lee, K. T., Choi, Y. H., Lee, S., & Kim, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109344 · Cited by 12 · see citing works

Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice

Wang, M., Zhang, Q., Lou, S., Jin, L., Wu, G., Wu, W., Tang, Q., Wang, Y., Long, X., Huang, P. C., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115660 · Cited by 11 · see citing works

Determination of α1‐adrenoceptor subtype selectivity by [3H]‐prazosin displacement studies in guinea‐pig cerebral cortex and rat spleen membranes

Veenstra, D. M. J., Buuren, K. J. H. V., & Nijkamp, F. P. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14487.x · Cited by 10 · see citing works

Novel O-benzylcinnamic acid derivative L26 treats acute lung injury in mice by MD-2

Li, X., Yin, L., Liao, J., Yang, J., Cai, B., Yu, Y., Su, S., Du, Z., Li, X., Zhou, Y., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115289 · Cited by 9 · see citing works

Blocking α1 Adrenergic Receptor as a Novel Target for Treating Alzheimer’s Disease

Pan, X., Lei, Z., Chen, J., Jia, C., Deng, J., Liu, Y., Luo, X., Wang, L., Zi, D., Wang, Z., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00411 · Cited by 5 · see citing works

Compound c17 alleviates inflammatory cardiomyopathy in streptozotocin-induced diabetic mice by targeting MyD88

Zhang, Q., Zhu, W., Lou, S., Bao, H., Zhou, Y., Cai, Z., Ye, J., Cui, Y., Wang, M., Jin, L., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110863 · Cited by 5 · see citing works

Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages

Aquino, J. B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792423 · Cited by 1 · see citing works

Inhibition of MD2‐dependent inflammation attenuates the progression of non‐alcoholic fatty liver disease

Zhang, Y., Wu, B., Zhang, H., Ge, X., Ying, S., Hu, M., Li, W., Huang, Y., Wang, L., Chen, C., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13395 · Cited by 29 · see citing works

Compound J27 alleviates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease by targeting JNK

Ye, J., Zhu, W., Cui, Y., Zhang, Q., Xiong, Y., Jin, L., Wang, A., Lin, M., Dong, H., Liang, G., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114570 · Cited by 3 · see citing works

A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice

Jin, L., Wang, M., Yang, B., Ye, L., Zhu, W., Zhang, Q., Lou, S., Zhang, Y., Luo, W., & Liang, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109587 · Cited by 17 · see citing works

The inhibition of Il1β synthesis mediated by a novel pyridine-sulfonamide compound protects against the progression of metabolic dysfunction-associated steatotic liver disease

Berlana, Á., Rey, E., Fresno-Ventura, E., Gómez‐Gutierrez, P., Vega, M., García‐Monzón, C., & González‐Rodríguez, Á. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119052

#119 - MARESIN 1 MODULATES NUCLEAR RECEPTOR SIGNALING AND NF-B ACTIVATION IN AN EXPERIMENTAL MODEL OF MASLD ASSOCIATED WITH TYPE 2 DIABETES

Zúñiga‐Hernández, J., & Quiñones, M. (2026) · Annals of Hepatology · doi:10.1016/j.aohep.2026.102377