The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy
Open accessAbstract
Covalent organic frameworks (COFs), an emerging class of organic porous materials, have attracted intense attention due to their versatile applications. However, the deliberate fabrication of COF-based nanomaterials for nanomedical application remains challenging due to difficulty in their size- and structure-controlled synthesis and poor aqueous dispersibility. Herein, we report two boron-dipyrromethene (BODIPY)-decorated nanoscale COFs (NCOFs), which were prepared by the Schiff-base condensation of the free end -CHO (bonding defects in COFs) on the established imine-based NCOFs with the amino-substituted organic photosensitizer BODIPY via "bonding defects functionalization" approach. Thus BODIPY has been successfully nanocrystallized via the NCOF platform, and can be used for photodynamic therapy (PDT) to treat tumors. These NCOF-based PDT agents featured nanometer size (∼110 nm), low dark toxicity, and high phototoxicity as evidenced by in vitro and in vivo experiments. Moreover, the "bonding defects functionalization" approach might open up new avenues for the fabrication of additional COF-based platforms for biomedical treatment.
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Siegel, R. L., Miller, K. D., & Jemal, A. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21551 · Cited by 20,160
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
Liang, C.-C., Park, A. Y., & Guan, J.-L. (2007) · Nature Protocols · doi:10.1038/nprot.2007.30 · Cited by 4,696
Vyas, S., Zaganjor, E., & Haigis, M. C. (2016) · Cell · doi:10.1016/j.cell.2016.07.002 · Cited by 1,735
Cited by
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy
He, X., Jiang, Z., Akakuru, O. U., Li, J., & Wu, A. (2021) · Chemical Communications · doi:10.1039/d1cc04846e · Cited by 303
Metadata
- Authors
- Guan, Q., Fu, D.-D., Li, Y.-A., Kong, X.-M., Wei, Z.-Y., Li, W.-Y., Zhang, S.-J., & Dong, Y.-B.
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 14
- Pages
- 180-198
- ISSN
- 2589-0042 (ISSN-L)
- OpenAlex
- W2925775343
- Cited by
- 179
- References
- 4
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guan, Q., Fu, D.-D., Li, Y.-A., Kong, X.-M., Wei, Z.-Y., Li, W.-Y., Zhang, S.-J., & Dong, Y.-B. (2019). BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy. iScience. https://doi.org/10.1016/j.isci.2019.03.028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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