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Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

Shin, Woojung, Hinojosa, Christopher D., Ingber, Donald E., Kim, Hyun Jung·2019·iScience
DOI 10.1016/j.isci.2019.04.037PMC PMC6526295
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  • These microfluidic devices can apply only one flow rate for the introduced tissues although the gut and liver require different flow rates to realize their proper functions.

    “for example, we can apply only one flow rate for the introduced tissues although the gut and liver require different flow rates to realize their proper functions.17,18”

    From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [17]

    The Results section ('Computer Simulation Predicts Transepithelial Morphogen Gradient'; page unavailable) shows that intestinal epithelial morphogenesis varies with flow rate, supporting the point that flow conditions matter for gut tissue. The paper does not establish that gut and liver require different flow rates, or that a device containing both tissues can apply only one flow rate. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Shin, W., Hinojosa, C. D., Ingber, D. E., & Kim, H. J.
Venue
iScience
Publisher
Elsevier BV
Published
2019-05
Volume
15
Pages
391-406
ISSN
2589-0042
DOI
10.1016/j.isci.2019.04.037
PMC
PMC6526295
Cited by
190
References
12
Language
en
Licence
Funders
  • Leona M. and Harry B. Helmsley Charitable Trust
  • Defense Advanced Research Projects Agency
  • Alternatives Research and Development Foundation
  • Cancer Research Institute
  • International Foundation for Ethical Research
  • U.S. Food and Drug Administration

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