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Cited by 48Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunologyinterferon and immune responses

IFNγR2 trafficking tunes IFNγ–STAT1 signaling in T lymphocytes

Regis, Gabriella, Conti, Laura, Boselli, Daniela, Novelli, Francesco·2006·Trends in Immunology
DOI 10.1016/j.it.2005.12.002
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Abstract

Ligand-dependent downregulation of the interferon gamma receptor signaling chain (IFNgammaR2) has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of transcription 1 (STAT1) pathway. Now, however, a ligand-independent mechanism of IFNgammaR2 internalization is emerging as a more general way of limiting IFNgamma-STAT1 signaling in T cells, with insulin-like growth factor-1 (IGF-1) and iron as the main players. Here, we review the array of immunomodulatory effects exerted by these two factors on different cell types involved in the immune response; these effects suggest that an inflammatory environment generates signals that favor IFNgammaR2 cell-surface accumulation and IFNgamma-induced apoptosis in T cells, whereas an anti-inflammatory environment promotes IFNgammaR2 internalization and induces T cell unresponsiveness to IFNgamma signaling.

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  • Iron chelation causes upregulation of IFNGR2 while it inhibits TH1 cell proliferation and thus IFN-γ output.

    “On the other hand, iron chelation causes an upregulation of IFNGR2 while it inhibits T H 1 cell proliferation and thus IFN-γ output (Regis et al., 2005(Regis et al., , 2006)).”

    From Iron in infection and immunity (2020) · cites this paper as Regis et al., 2006

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Authors
Regis, G., Conti, L., Boselli, D., & Novelli, F.
Affiliations
  • Azienda Ospedaliero Universitaria San Giovanni Battista (IT)
  • University of Turin (IT)
Corresponding author
Novelli, Francesco
ORCID
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2006-02
Volume
27
Issue
2
Pages
96-101
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2005.12.002
OpenAlex
W2044060183
Cited by
48
References
79
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 4
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
Compagnia di San Paolo
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
STAT1 signaling, T cells, receptor internalization, insulin-like growth factor I, iron, T cell hyporesponsiveness, immunomodulation, inflammatory environment
MeSH terms
Interferon gamma Receptor, Animals, Humans, Interferon-gamma, T-Lymphocytes, Signal Transduction, Receptors, Interferon, Protein Transport, STAT1 Transcription Factor

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