The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Innate immunity and adipose tissue biology
Abstract
The understanding of the role of adipose tissue has changed from a lipid storage organ to an endocrine and immunologically active organ. Here, we summarize the evidence for an important role of adipose tissue in innate immunity. The review focuses on the expression and function of Toll-like receptors (TLRs) in adipocytes and on the role of adipose tissue macrophages. The dual activation of TLR4 in adipocytes by lipopolysaccharide and fatty acids represents a molecular gate that connects innate immunity with metabolism. Dichotomic molecules derived from ancient precursor molecules control metabolism and immune function. Visceral adipose tissue is infiltrated by macrophages in obesity, and there is local crosstalk between these two types of cells, leading to an inflammatory transformation of adipose tissue.
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“Gut‐derived endotoxin can trigger fat inflammation, which is considered to be the main driver of systemic inflammation in metabolic syndrome by releasing adipokines (Schaffler & Scholmerich, 2010).”
From Akkermansia muciniphila alleviates high‐fat‐diet ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Schaffler & Scholmerich, 2010
In the citing paper
“Lipopolysaccharide can also act on Toll-like receptor 4 in adipocytes to stimulate the production of proinflammatory adipokines and to further reinforce the systemic inflammation.”
From Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016) · cites this paper as [45]
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
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TLR4 links innate immunity and fatty acid-induced insulin resistance
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Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608
Cooperation of Toll-like receptor signals in innate immune defence
Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,394
Normalization of obesity-associated insulin resistance through immunotherapy
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Research works printed but not linked: 1
- Delzenne, 2008, [Gut microflora is a key player in host energy homeostasis], Med. Sci., 24, 505
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State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,201
Picon‐Ruiz, M., Morata‐Tarifa, C., Valle‐Goffin, J. J., Friedman, E. R., & Slingerland, J. M. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21405 · Cited by 932
Li, J., Lin, S., Vanhoutte, P. M., Woo, C. W., & Xu, A. (2016) · Circulation · doi:10.1161/circulationaha.115.019645 · Cited by 775
Toll-like receptor signaling in neural plasticity and disease
Okun, E., Griffioen, K. J. S., & Mattson, M. P. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.005 · Cited by 529
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471
Metadata
- Authors
- Schäffler, A., & Schölmerich, J.
- Affiliations
- University Hospital Regensburg (DE)
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 31
- Issue
- 6
- Pages
- 228-235
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2086125606
- Cited by
- 283
- References
- 66
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 4 · 2023: 14 · 2022: 17 · 2021: 32 · 2020: 20 · 2019: 21 · 2018: 21 · 2017: 19 · 2016: 12 · 2015: 19 · 2014: 19 · 2013: 21 · 2012: 15
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- innate immunity, adipose tissue, Toll-like receptors, TLR4, adipocytes, adipose tissue macrophages, visceral adipose tissue, obesity, lipopolysaccharide, fatty acids, adipose tissue inflammation
- MeSH terms
- Adipose Tissue, Animals, Cell Communication, Humans, Immunity, Innate, Macrophages, Signal Transduction, Toll-Like Receptors
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