Cited by 283Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune Response and Inflammation

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Innate immunity and adipose tissue biology

Schäffler, Andreas, Schölmerich, Jürgen·2010·Trends in Immunology

DOI 10.1016/j.it.2010.03.001

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Abstract

The understanding of the role of adipose tissue has changed from a lipid storage organ to an endocrine and immunologically active organ. Here, we summarize the evidence for an important role of adipose tissue in innate immunity. The review focuses on the expression and function of Toll-like receptors (TLRs) in adipocytes and on the role of adipose tissue macrophages. The dual activation of TLR4 in adipocytes by lipopolysaccharide and fatty acids represents a molecular gate that connects innate immunity with metabolism. Dichotomic molecules derived from ancient precursor molecules control metabolism and immune function. Visceral adipose tissue is infiltrated by macrophages in obesity, and there is local crosstalk between these two types of cells, leading to an inflammatory transformation of adipose tissue.

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Authors: Schäffler, A., & Schölmerich, J.
Affiliations: University Hospital Regensburg (DE)
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2010-06
Volume: 31
Issue: 6
Pages: 228-235
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2010.03.001
OpenAlex: W2086125606
Cited by: 283
References: 66
Citations by year: 2026: 5 · 2025: 12 · 2024: 4 · 2023: 14 · 2022: 17 · 2021: 32 · 2020: 20 · 2019: 21 · 2018: 21 · 2017: 19 · 2016: 12 · 2015: 19 · 2014: 19 · 2013: 21 · 2012: 15
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: innate immunity, adipose tissue, Toll-like receptors, TLR4, adipocytes, adipose tissue macrophages, visceral adipose tissue, obesity, lipopolysaccharide, fatty acids, adipose tissue inflammation
MeSH terms: Adipose Tissue, Animals, Cell Communication, Humans, Immunity, Innate, Macrophages, Signal Transduction, Toll-Like Receptors

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