The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Lymph node stroma broaden the peripheral tolerance paradigm
Open accessAbstract
Research into how self-reactive T cells are tolerized in lymph nodes has focused largely on dendritic cells (DCs). We now know that lymph node stromal cells (LNSC) are important mediators of deletional tolerance to peripheral tissue-restricted antigens (PTAs), which are constitutively expressed and presented by LNSCs. Of the major LNSC subsets, fibroblastic reticular cells and lymphatic endothelial cells are known to directly induce tolerance of responding naïve CD8 T cells. The biological outcome of this interaction fills a void otherwise not covered by DCs or thymic stromal cells. These findings, we suggest, necessitate a broadening of peripheral tolerance theory to include steady-state presentation of clinically relevant PTA to naïve CD8 T cells by lymph node-resident stroma.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In addition, they promote immune tolerance by the expression and presentation of normally tissue-restricted antigens22.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z.-B., Berzins, S., Turley, S., von Boehmer, H., Bronson, R., Dierich, A., Benoist, C., et al. (2002) · Science · doi:10.1126/science.1075958 · Cited by 2,582
Self-citationRen, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A. I., Zhao, R. C., & Shi, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.014 · Cited by 2,101
A chemokine-driven positive feedback loop organizes lymphoid follicles
Ansel, K. M., Ngo, V. N., Hyman, P. L., Luther, S. A., Förster, R., Sedgwick, J. D., Browning, J. L., Lipp, M., & Cyster, J. G. (2000) · Nature · doi:10.1038/35018581 · Cited by 1,282
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
Derbinski, J., Schulte, A., Kyewski, B., & Klein, L. (2001) · Nature Immunology · doi:10.1038/ni723 · Cited by 1,163
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.
Bajénoff, M., Egen, J., Koo, L. Y., Laugier, J., Brau, F., Glaichenhaus, N., & Germain, R. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.011 · Cited by 1,022
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
Link, A., Vogt, T. K., Favre, S., Britschgi, M. R., Acha‐Orbea, H., Hinz, B., Cyster, J. G., & Luther, S. A. (2007) · Nature Immunology · doi:10.1038/ni1513 · Cited by 948
Lymphoid neogenesis in chronic inflammatory diseases
Aloisi, F., & Pujol‐Borrell, R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1786 · Cited by 909
Toll-dependent selection of microbial antigens for presentation by dendritic cells
Blander, J. M., & Medzhitov, R. M. (2006) · Nature · doi:10.1038/nature04596 · Cited by 841
Flagged first, then by citations
Cited by
Sorted by citations
A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863
Cross-presentation by dendritic cells
Joffre, O. P., Segura, É., Savina, A., & Amigorena, S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3254 · Cited by 1,764
T-Cell Tolerance: Central and PeripheralPreprint
Xing, Y., & Hogquist, K. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006957 · Cited by 621
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Swartz, M. A., & Lund, A. W. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3186 · Cited by 544
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 498
Metadata
- Authors
- Fletcher, A. L., Malhotra, D., & Turley, S. J.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Harvard University (US)
- Corresponding author
- Turley, Shannon J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 32
- Issue
- 1
- Pages
- 12-18
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC3163075
- OpenAlex
- W2109445521
- Cited by
- 120
- References
- 69
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 16
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074500)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lymph node stroma, peripheral tolerance, tissue-restricted antigens, fibroblastic reticular cells, lymphatic endothelial cells, CD8+ T cell tolerance, autoreactive T cells, dendritic cells, thymic stromal cells
- MeSH terms
- Animals, Dendritic Cells, Humans, Immune Tolerance, Lymph Nodes, Stromal Cells, Antigen Presentation, CD8-Positive T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
