Cited by 120T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

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Lymph node stroma broaden the peripheral tolerance paradigm

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Fletcher, Anne L., Malhotra, Deepali, Turley, Shannon J.·2011·Trends in Immunology

DOI 10.1016/j.it.2010.11.002PMC PMC3163075

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Abstract

Research into how self-reactive T cells are tolerized in lymph nodes has focused largely on dendritic cells (DCs). We now know that lymph node stromal cells (LNSC) are important mediators of deletional tolerance to peripheral tissue-restricted antigens (PTAs), which are constitutively expressed and presented by LNSCs. Of the major LNSC subsets, fibroblastic reticular cells and lymphatic endothelial cells are known to directly induce tolerance of responding naïve CD8 T cells. The biological outcome of this interaction fills a void otherwise not covered by DCs or thymic stromal cells. These findings, we suggest, necessitate a broadening of peripheral tolerance theory to include steady-state presentation of clinically relevant PTA to naïve CD8 T cells by lymph node-resident stroma.

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Authors: Fletcher, A. L., Malhotra, D., & Turley, S. J.
Affiliations: Dana-Farber Cancer Institute (US)
Harvard University (US)
Corresponding author: Turley, Shannon J.
ORCID: Fletcher, Anne L.
Malhotra, Deepali
Turley, Shannon J.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2011-01
Volume: 32
Issue: 1
Pages: 12-18
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2010.11.002
PMC: PMC3163075
OpenAlex: W2109445521
Cited by: 120
References: 69
Citations by year: 2026: 1 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 16
FWCI: 0.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074500)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: lymph node stroma, peripheral tolerance, tissue-restricted antigens, fibroblastic reticular cells, lymphatic endothelial cells, CD8+ T cell tolerance, autoreactive T cells, dendritic cells, thymic stromal cells
MeSH terms: Animals, Dendritic Cells, Humans, Immune Tolerance, Lymph Nodes, Stromal Cells, Antigen Presentation, CD8-Positive T-Lymphocytes

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Lymph node stroma broaden the peripheral tolerance paradigm

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