Syk-coupled C-type lectins in immunity

Kerrigan, Ann M.; Brown, Gordon D.

doi:10.1016/j.it.2011.01.002

Cited by 170Immune Response and InflammationImmune responses and vaccinationsImmunotherapy and Immune Responses

Syk-coupled C-type lectins in immunity

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Kerrigan, Ann M., Brown, Gordon D.·2011·Trends in Immunology

DOI 10.1016/j.it.2011.01.002PMC PMC3074083

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Abstract

The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses. It subsequently emerged that Dectin-1 is one of a number of spleen tyrosine kinase-coupled C-type lectin receptors that have been implicated not just in fungal immunity, but also in viral, mycobacterial and helminth infections. Here, we consider the ability of these receptors to trigger different aspects of immunity and highlight their emerging roles in a number of infection scenarios.

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SYK participates in the innate recognition of fungal and other microbial pathogens, as well as of tissue damage, by C-type lectins.
“SYK participates in the innate recognition of fungal and other microbial pathogens, as well as of tissue damage, by C-type lectins.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [97]

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Self-citation
Dectin-1: a signalling non-TLR pattern-recognition receptor
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Self-citation
IMMUNOBIOLOGY Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses
LeibundGut‐Landmann, S., Osorio, F., Brown, G. D., & Sousa, C. R. E. (2016)
Self-citation

Authors: Kerrigan, A. M., & Brown, G. D.
Affiliations: University of Aberdeen (GB)
Corresponding author: Brown, Gordon D.
ORCID: Brown, Gordon D.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2011-04
Volume: 32
Issue: 4
Pages: 151-156
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2011.01.002
PMC: PMC3074083
OpenAlex: W2004875277
Cited by: 170
References: 72
Citations by year: 2026: 1 · 2025: 8 · 2024: 2 · 2023: 8 · 2022: 14 · 2021: 5 · 2020: 16 · 2019: 11 · 2018: 13 · 2017: 12 · 2016: 13 · 2015: 6 · 2014: 20 · 2013: 17 · 2012: 19
FWCI: 1.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor, 837 d)
Locations: Trends in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Wellcome Trust (086558)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Dectin-1, C-type lectin receptors, Syk, innate immunity, antifungal immunity, adaptive immune response, viral infection, mycobacterial infection, helminthiasis, receptor signaling
MeSH terms: Syk Kinase, Dectin-1, Animals, Humans, Ligands, Membrane Proteins, Nerve Tissue Proteins, Protein Binding, Protein-Tyrosine Kinases, Receptors, Calcitonin, Lectins, C-Type, Intracellular Signaling Peptides and Proteins

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Syk-coupled C-type lectins in immunity

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