C-type lectin receptors orchestrate antifungal immunity

Hardison, Sarah E; Brown, Gordon D

doi:10.1038/ni.2369

Cited by 460Immune Response and InflammationAntifungal resistance and susceptibilityImmune responses and vaccinations

C-type lectin receptors orchestrate antifungal immunity

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Hardison, Sarah E, Brown, Gordon D·2012·Nature Immunology

DOI 10.1038/ni.2369PMC PMC3432564

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Abstract

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

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β-1,3-glucan binds to Dectin-1 on host immune cells and promotes phagocytosis and inflammatory responses.
“As the primary fungal pathogen-associated molecular pattern (PAMP), β-1,3-glucan binds to Dectin-1, a C-type lectin pattern recognition receptor (PRR) of the host’s immune cells [11]; and promotes phagocytosis and inflammatory responses [12].”
From High iron-mediated increased oral fungal burden, oral-to-gut transmission, and changes to pathogenicity of Candida albicans in oropharyngeal candidiasis (2022) · cites this paper as [12]

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Authors: Hardison, S. E., & Brown, G. D.
Affiliations: University of Aberdeen (GB)
Corresponding author: Brown, Gordon D
ORCID: Brown, Gordon D
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2012-08-21
Volume: 13
Issue: 9
Pages: 817-822
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2369
PMC: PMC3432564
OpenAlex: W1982029015
Cited by: 460
References: 101
Citations by year: 2026: 16 · 2025: 17 · 2024: 25 · 2023: 28 · 2022: 27 · 2021: 36 · 2020: 31 · 2019: 30 · 2018: 48 · 2017: 46 · 2016: 34 · 2015: 34 · 2014: 50 · 2013: 38
FWCI: 3.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (086558)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: C-type lectin receptors, antifungal immunity, pattern recognition receptors, innate immunity, fungal infection, intracellular signaling, adaptive immune response, vaccine targets, antifungal vaccines
MeSH terms: Animals, Fungal Vaccines, Fungi, Humans, Mycoses, Signal Transduction, Lectins, C-Type, Receptors, Pattern Recognition

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C-type lectin receptors orchestrate antifungal immunity

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