NLRP3 inflammasomes link inflammation and metabolic disease

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Items 101–200 of 431

1. Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators
   Dongling Liu, Xiang Zeng, Xiao Li, Chaochu Cui, Ruanling Hou, Zhikun Guo, Jawahar L. Mehta, Xianwei Wang · 2020 · Biochemical Pharmacology
2. Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis
   Mattia Cocco, Davide Garella, Antonella Di Stilo, Emily Borretto, Livio Stevanato, Marta Giorgis, Elisabetta Marini, Roberto Fantozzi, Gianluca Miglio, Massimo Bertinaria · 2014 · Journal of Medicinal Chemistry
3. A Protective Role of Glibenclamide in Inflammation-Associated Injury
   Gensheng Zhang, Xiuhui Lin, Shufang Zhang, Huiqing Xiu, Chuli Pan, Wei Cui · 2017 · Mediators of Inflammation
4. Microglia activation due to obesity programs metabolic failure leading to type two diabetes
   Roger Maldonado‐Ruiz, Larisa Montalvo-Martínez, Lizeth Fuentes‐Mera, Alberto Camacho‐Morales · 2017 · Nutrition and Diabetes
5. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells
   Hisa Hui Ling Tseng, Chi Teng Vong, Yiu Wa Kwan, Simon Ming‐Yuen Lee, Maggie Pui Man Hoi · 2016 · Scientific Reports
6. Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome
   Yochai Birnbaum, Mandeep Bajaj, Jinqiao Qian, Yumei Ye · 2016 · BMJ Open Diabetes Research & Care
7. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
   Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, Tao Yang, Yin Huang, Xinyang Song, Yongqin Li, Lilin Ye, Nan Shen et al. · 2017 · Nature Communications
8. IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways
   Rafael Simó, Anna Barbosa-Desongles, Cristina Hernández, David M. Selva · 2012 · Molecular Endocrinology
9. Negative regulation of NLRP3 inflammasome signaling
   Shuzhen Chen, Bing Sun · 2013 · Protein & Cell
10. Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss
    Yaran Zang, Ju Han Song, So‐Young Oh, J W Kim, M.N. Lee, Xianyu Piao, Jin-Woo Yang, O.S. Kim, T S Kim, S H Kim et al. · 2020 · Journal of Dental Research
11. Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation
    Keliang Xie, Yang Zhang, Yaoqi Wang, Xiaoyin Meng, Yuzun Wang, Yonghao Yu, Hongguang Chen · 2020 · Inflammation Research
12. The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases
    Chul‐Su Yang, Dong–Min Shin, Eun‐Kyeong Jo · 2012 · International Neurourology Journal
13. Conjugated Linoleic Acid Ameliorates High Fructose‐Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway
    Jianyang Tan, Liping Wan, Xiaofang Chen, Xiaolei Li, Xiaoxu Hao, Xiaofei Li, Jian Li, Hong Ding · 2019 · Molecular Nutrition & Food Research
14. Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress
    Yue Zhao, Qinglong Guo, Qin Zhu, Ren Xiang Tan, Dongsheng Bai, Xiumin Bu, Binyan Lin, Kai Zhao, Chuyue Pan, Haiyan Chen et al. · 2019 · Mucosal Immunology
15. The rhapsody of NLRPs: master players of inflammation … and a lot more
    Lia Paola Zambetti, Federica Laudisi, Ginevra Licandro, Paola Ricciardi‐Castagnoli, Alessandra Mortellaro · 2012 · Immunologic Research
16. Target acquired: Selective autophagy in cardiometabolic disease
    Trent D. Evans, Ismail Sergin, Xiangyu Zhang, Babak Razani · 2017 · Science Signaling
17. Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis
    Jing Xu, Munehiro Kitada, Yoshio Ogura, Daisuke Koya · 2021 · Frontiers in Cell and Developmental Biology
18. The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome
    Maria Consiglia Trotta, Rosa Maisto, Francesca Guida, Serena Boccella, Livio Luongo, Cornel Baltă, Giovanbattista D’Amico, Hildegard Herman, Anca Oana Hermenean, Claudio Bucolo et al. · 2019 · PLoS ONE
19. The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases
    Stella Bernardi, Annalisa Marcuzzi, Elisa Piscianz, Alberto Tommasini, Bruno Fabris · 2018 · International Journal of Molecular Sciences
20. AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection
    Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li et al. · 2022 · Virulence
21. Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease
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22. Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice
    Ge Tang, Fengqi Duan, Weixuan Li, Yiqin Wang, Cheng Zeng, Jia Hu, Hongyu Li, Xuanhong Zhang, Yanming Chen, Hongmei Tan · 2019 · Biomedicine & Pharmacotherapy
23. Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
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24. Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction
    Yang Zhang, Yang Chen, Youzhi Zhang, Pin‐Lan Li, Xiang Li · 2019 · European Journal of Pharmacology
25. New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation
    Martin Pelletier, Talya S. Lepow, Leah K. Billingham, Michael P. Murphy, Richard M. Siegel · 2012 · Seminars in Immunology
26. Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in rats
    Zhengwang Cao, Yiliang Fang, Yonghui Lu, Fenghua Qian, Qinglong Ma, Mingdi He, Huifeng Pi, Zhengping Yu, Zhou Zhou · 2016 · International Journal of Nanomedicine
27. Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-κB signaling pathway in RAW264.7 macrophages
    Wang Liao, Xiaojie He, Zhu-Wen Yi, Wei Xiang, Yan Ping Ding · 2018 · Biomedicine & Pharmacotherapy
28. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction
    Edward D. Coverstone, Richard G. Bach, Li-Shiun Chen, Laura Jean Bierut, Allie Y. Li, Petra A. Lenzini, Heidi C. O’Neill, John A. Spertus, Carmen C. Sucharov, Jerry A. Stitzel et al. · 2018 · Basic Research in Cardiology
29. Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology
    Fan Meng, Bin Guo, Yi-qing Ma, Kunwei Li, Fengju Niu · 2022 · Phytomedicine
30. The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages
    Raquel Alvarado, Joyce To, Maria E. Lund, Anita A. Pinar, Ashley S. Mansell, Mark W. Robinson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly · 2016 · The FASEB Journal
31. Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice
    Shuang Chen, Janet L. Markman, Kenichi Shimada, Timothy R. Crother, Malcolm E. Lane, Amanda Abolhesn, Prediman K. Shah, Moshe Arditi · 2020 · JACC Basic to Translational Science
32. Gut mycobiome and metabolic diseases: The known, the unknown, and the future
    Lijie Wang, Kun Zhang, Yujiao Zeng, Yuting Luo, Jiayan Peng, Jing Zhang, Tingting Kuang, Gang Fan · 2023 · Pharmacological Research
33. Thioredoxin‐Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes
    Ye Xiao, Ya Yi Huang, Huaxin Wang, Yang Wu, Yan Leng, Min Liu, Qian Sun, Zhongyuan Xia · 2016 · Oxidative Medicine and Cellular Longevity
34. Plasma exosomal miR-223 expression regulates inflammatory responses during cardiac surgery with cardiopulmonary bypass
    Kin-Shing Poon, Kalaiselvi Palanisamy, Shih‐Sheng Chang, Kuo-Ting Sun, Kuen‐Bao Chen, Ping-Chun Li, Tso‐Chou Lin, Chi‐Yuan Li · 2017 · Scientific Reports
35. GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics
    Tiantian Tang, Tao Gong, Wei Jiang, Rongbin Zhou · 2018 · Trends in Pharmacological Sciences
36. Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models
    Sandra Feijóo‐Bandín, Alana Aragón‐Herrera, Manuel Otero-Santiago, Laura Anido‐Varela, Sandra Moraña‐Fernández, Estefanía Tarazón, Esther Roselló‐Lletí, Manuel Portolés, Oreste Gualillo, José Ramón González‐Juanatey et al. · 2022 · International Journal of Molecular Sciences
37. Molecular pathways of NF-ĸB and NLRP3 inflammasome as potential targets in the treatment of inflammation in diabetic wounds: A review
    Huey Xhin Teh, Shou Jin Phang, Mee Lee Looi, Umah Rani Kuppusamy, Bavani Arumugam · 2023 · Life Sciences
38. Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies
    Elena Rampanelli, Nadia Romp, Antonio Dario Troise, Jakshana Ananthasabesan, Hao Wu, Ismail Sahin Gül, Sabrina De Pascale, Andrea Scaloni, Fredrik Bäckhed, Vincenzo Fogliano et al. · 2025 · Microbiome
39. Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells
    Dan He, Hongyan Wang, Ling Xu, Xiaoqing Wang, Peng Kuang, Lili Wang, Pixu Liu, Peng Qu · 2016 · Journal of Cardiovascular Pharmacology
40. The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury
    Bing F. Wang, Jun Yoshioka · 2016 · Journal of Cardiovascular Pharmacology and Therapeutics
41. Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis
    Shi Jie Tang, Chenlin Gao, Yang Long, Wei Gang Huang, Jiao Chen, Fang Fan, Chunxia Jiang, Yong Xu · 2017 · Mediators of Inflammation
42. Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows
    Taiyu Shen, Xinwei Li, Juan J. Loor, Yiwei Zhu, Xiliang Du, Xinghui Wang, Dongmei Xing, Zhen Shi, Zhiyuan Fang, Xiaobing Li et al. · 2019 · Journal of Dairy Science
43. Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway
    Jean Baptiste Nyandwi, Gyung Hyuck Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim · 2020 · Biochemical Pharmacology
44. Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome
    Linan Guan, Chao Li, Yi Zhang, Jianying Gong, Guangyu Wang, Pei Tian, Ning Shen · 2020 · Life Sciences
45. High-fat diet and neuroinflammation: The role of mitochondria
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46. 3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling
    Kang‐Yi Su, Chao Yuan Yu, Yaping Chen, Kuo‐Feng Hua, Yi‐Lin Sophia Chen · 2014 · BMC Complementary and Alternative Medicine
47. Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis
    Yohei Yamaguchi, Tomoko Kurita‐Ochiai, Ryoki Kobayashi, Toshihiko Suzuki, Tomohiro Ando · 2015 · Pathogens and Disease
48. Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling
    Jin Kyung Kim, Hyo Sun Jin, Hyun‐Woo Suh, Eun‐Kyeong Jo · 2017 · Immunology and Cell Biology
49. The role of inflammasome activation in Triptolide-induced acute liver toxicity
    Ziqiao Yuan, Muhammad Hasnat, Peishi Liang, Zihang Yuan, Haoran Zhang, Lixin Sun, Luyong Zhang, Zhenzhou Jiang · 2019 · International Immunopharmacology
50. Leukocyte Infiltration and Activation of the NLRP3 Inflammasome in White Adipose Tissue Following Thermal Injury*
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51. Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1βin Retinal Endothelial Cells and Mouse Retinal Vasculature
    Youde Jiang, Li Liu, Elizabeth Curtiss, Jena J. Steinle · 2017 · Mediators of Inflammation
52. Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities
    Miguel Angel Ortega, Diego De León-Oliva, Cielo García Montero, Oscar Fraile‐Μartinez, Diego Liviu Boaru, Amador Velazquez de Castro, Miguel A. Sáez, Laura López-González, Julia Buján, Miguel Ángel Álvarez-Mon et al. · 2023 · Frontiers in Immunology
53. Effects and mechanisms of SGLT2 inhibitors on the NLRP3 inflammasome, with a focus on atherosclerosis
    Liu Yang, Xuejiao Zhang, Qing Wang · 2022 · Frontiers in Endocrinology
54. Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment
    Zu Yue Deng, Meng Hu, Yanfei Xin, Chen Gang · 2015 · Inflammation Research
55. Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy
    Sumit Kar, Tyler N. Kambis, Paras Kumar Mishra · 2019 · American Journal of Physiology-Heart and Circulatory Physiology
56. Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin
    Itzel Y. Rojas, Benjamin J. Moyer, Carol S. Ringelberg, Craig R. Tomlinson · 2020 · International Journal of Obesity
57. Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
    Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago A. Patente, José Alexandre Marzagão Barbuto, Maria Lúcia Corrêa‐Giannella et al. · 2020 · Clinical Science
58. Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway
    Runyu Yang, Hanxi Yu, Jiaxi Chen, Jianwei Zhu, Changqin Song, Lvqi Zhou, Yang Sun, Qi Zhang · 2021 · Journal of Agricultural and Food Chemistry
59. Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes
    Han Liu, Ming-ming Cao, Yang Wang, Le-chen Li, Libo Zhu, Guangying Xie, Yanbo Li · 2014 · General and Comparative Endocrinology
60. Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages
    Neus Martínez-Micaelo, Noemi González‐Abuín, Montserrat Pinent, Anna Ardèvol, Mayte Blay · 2016 · Food & Function
61. Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways
    Yong, Zhang, Ruiqi, Wang, Hongji, Yao, Ning, Ma, Chenzuo, Jiang, Yu, Zhou, Zhixuan, Xia, Qiang, Liu, Qibing, Liu, Weiying, Lu et al. · 2021 · Journal of Immunology Research
62. Inflammatory processes in obesity: focus on endothelial dysfunction and the role of adipokines as inflammatory mediators
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63. Inflammatory Response Modulation by Vitamin C in an MPTP Mouse Model of Parkinson’s Disease
    Francesco De Nuccio, Antonia Cianciulli, Chiara Porro, Marianna Kashyrina, Melania Ruggiero, Rosa Calvello, Alessandro Miraglia, Giuseppe Nicolardi, Dario Domenico Lofrumento, Maria Antonietta Panaro · 2021 · Biology
64. DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2–COX-2–TP Axis and NLRP3 Inflammasome Activation
    Inés Valencia, Susana Vallejo, Pilar Dongil, Alejandra Romero, Álvaro San Hipólito‐Luengo, Licia Shamoon, María Posada-Ayala, Damián García‐Olmo, Raffaelle Carraro, Jorge D. Erusalimsky et al. · 2022 · Hypertension
65. Galangin Suppresses Renal Inflammation via the Inhibition of NF- κ B, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells
    Hao Lü, Hui Yao, Rong Zou, Xiwen Chen, Hanlin Xu · 2019 · BioMed Research International
66. From inflammasome to Parkinson’s disease: Does the NLRP3 inflammasome facilitate exosome secretion and exosomal alpha-synuclein transmission in Parkinson’s disease?
    Xiaoli Si, Yuanjian Fang, Lingfei Li, Luyan Gu, Xinzhen Yin, Jun-Tian, Yaping Yan, Jiali Pu, Baorong Zhang · 2020 · Experimental Neurology
67. Recombinant adenovirus encoding NLRP3 RNAi attenuate inflammation and brain injury after intracerebral hemorrhage
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68. Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes
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69. Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene
    Krishna Murthy Boini, Min Xia, Saisudha Koka, Todd W.B. Gehr, Pin‐Lan Li · 2016 · Oncotarget
70. Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation
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71. The active components derived from Penthorum chinense Pursh protect against oxidative-stress-induced vascular injury via autophagy induction
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72. Amorphous Nanosilica induced Toxicity, Inflammation and Innate Immune Responses: A Critical Review.
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73. and Metabolic Disease
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74. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome
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75. IL-1 and atherosclerosis: a murine twist to an evolving human story
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76. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways
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77. Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells.
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78. PKR induces the expression of NLRP3 by regulating the NF-κB pathway in Porphyromonas gingivalis -infected osteoblasts
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79. NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients
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80. microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3
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81. Suppression of lncRNA NLRP3 inhibits NLRP3-triggered inflammatory responses in early acute lung injury
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82. Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis: EXPERT'S PERSPECTIVE
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83. NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions
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84. Electroacupuncture Could Influence the Expression of IL‐1β and NLRP3 Inflammasome in Hippocampus of Alzheimer’s Disease Animal Model
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85. Oral treatment with glycyrrhizin inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization after traumatic spinal cord injury
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86. The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases
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87. Vitamin D3Metabolites Enhance the NLRP3-Dependent Secretion of IL-1β From Human THP-1 Monocytic Cells
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88. Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
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89. RETRACTED ARTICLE: Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy
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90. Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study
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91. Relationships between Serum Resistin and Fat Intake, Serum Lipid Concentrations and Adiposity in the General Population
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92. Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly
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93. Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages
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94. Flavonoids and cellular stress: a complex interplay affecting human health
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95. Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice
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96. MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1
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97. Pathogenesis of infection in surgical patients
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98. The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation
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99. Comparison of how ambient PMcand PM2.5influence the inflammatory potential
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100. A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation
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