Cited by 431Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic DiseasesImmune Response and Inflammation

NLRP3 inflammasomes link inflammation and metabolic disease

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De Nardo, Dominic, Latz, Eicke·2011·Trends in Immunology

Abstract

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

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Authors
De Nardo, D., & Latz, E.
Affiliations
University of Bonn (DE)
Corresponding author
Latz, Eicke
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2011-08
Volume
32
Issue
8
Pages
373-379
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2137573856
Cited by
425
References
72
Citations by year
2026: 21 · 2025: 22 · 2024: 17 · 2023: 19 · 2022: 26 · 2021: 39 · 2020: 33 · 2019: 36 · 2018: 29 · 2017: 37 · 2016: 20 · 2015: 36 · 2014: 37 · 2013: 27 · 2012: 19
FWCI
2.55
Type
journal article
Language
en
Open access
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL093262)
  • National Institute of Allergy and Infectious Diseases (R01AI083713)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
NLRP3 inflammasome, inflammation, metabolic disorders, obesity, atherosclerosis, type 2 diabetes, IL-1β, inflammasome-targeted therapy
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Humans, Immunotherapy, Inflammation, Metabolic Diseases, Interleukin-18, Interleukin-1beta, Inflammasomes, Molecular Targeted Therapy

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