NLRP3 inflammasomes link inflammation and metabolic disease
Open accessAbstract
A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
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IL-1β is a major atheroprone factor that promotes development of lipid plaques and destabilizes plaques by upregulating adhesion molecules including VCAM-1 and ICAM-1.
“IL‐1β is a major atheroprone factor that plays a significant role in promoting the development of lipid plaques and destabilizing plaques by upregulating adhesion molecules, including vascular cell adhesion molecule‐1 and ICAM‐1.31, 32, 33”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [31]
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- Authors
- De Nardo, D., & Latz, E.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Latz, Eicke
- ORCID
- Latz, Eicke
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 32
- Issue
- 8
- Pages
- 373-379
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC3151541
- OpenAlex
- W2137573856
- Cited by
- 425
- References
- 72
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 17 · 2023: 19 · 2022: 26 · 2021: 39 · 2020: 33 · 2019: 36 · 2018: 29 · 2017: 37 · 2016: 20 · 2015: 36 · 2014: 37 · 2013: 27 · 2012: 19
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL093262)
- National Institute of Allergy and Infectious Diseases (R01AI083713)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- NLRP3 inflammasome, inflammation, metabolic disorders, obesity, atherosclerosis, type 2 diabetes, IL-1β, inflammasome-targeted therapy
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Humans, Immunotherapy, Inflammation, Metabolic Diseases, Interleukin-18, Interleukin-1beta, Inflammasomes, Molecular Targeted Therapy
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