Cited by 43Inflammasome and immune disordersNitric Oxide and Endothelin EffectsTelomeres, Telomerase, and Senescence

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome

Sun, Chunhui, Fan, Shaohua, Wang, Xin, Lu, Jun, Zhang, Zifeng, Wu, Dongmei, Shan, Qun, Zheng, Yuanlin·2015·The Journal of Nutritional Biochemistry

Abstract

Purple sweet potato color (PSPC), flavonoids isolated from purple sweet potato, has been well demonstrated for the pharmacological properties. In the present study, we attempt to explore whether the antisenescence was involved in PSPC-mediated protection against endothelium dysfunction in type 2 diabetes mellitus (T2DM) and, if involved, what are the possible mechanisms. The results showed that atherogenesis and endothelial senescence in the thoracic aorta were promoted in mice with prediabetes; meanwhile, PSPC attenuated the deterioration of vascular vessel and inhibited the endothelial senescence. Diabetes mellitus is a documented high-risk factor for the development of atherosclerosis. Studies show that D-galactose (D-gal) promotes endothelial cell senescence in vitro. In our study, we have determined that PSPC could suppress the D-gal-induced premature senescence and the abnormal endothelial function, discovered in the early stages of atherosclerosis induced by T2DM. We have discovered that the PSPC down-regulates reactive oxygen species (ROS) accumulation and the NLRP3 inflammasome functions. Furthermore, the premature senescence induced by D-gal was inhibited after attenuation of ROS and deactivation of NLRP3 inflammasomes. However, once the NLRP3 inflammasomes are overactivated, PSPC could not restrain cell senescence. These data imply that the beneficial effects of PSPC on diabetes-induced endothelial dysfunction and senescence are mediated through ROS and NLRP3 signaling pathways, suggesting a potential target for the prevention of endothelial senescence-related cardiovascular diseases.

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Crossref · 10.1016/j.jnutbio.2015.04.012

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Authors
Sun, C., Fan, S., Wang, X., Lu, J., Zhang, Z., Wu, D., Shan, Q., & Zheng, Y.
Affiliations
Jiangsu Normal University (CN)
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2015-10
Volume
26
Issue
10
Pages
1029-1040
ISSN
0955-2863 (ISSN-L)
OpenAlex
W1792501638
Cited by
43
References
73
Citations by year
2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 1
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Nutritional Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Michigan
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
flavonoids, endothelial cell senescence, NLRP3 inflammasome, reactive oxygen species, endothelial dysfunction, type 2 diabetes, prediabetes, atherosclerosis, galactose, atherogenesis, cardiovascular disease prevention
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Diabetes Mellitus, Type 2, Flavonoids, Galactose, Humans, Insulin Resistance, Male, Mice, Inbred ICR, Pigments, Biological, Signal Transduction, Cellular Senescence, Reactive Oxygen Species, Ipomoea batatas, Endothelial Cells, Atherosclerosis, Mice, Inflammasomes, Human Umbilical Vein Endothelial Cells

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