The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A deep profiler's guide to cytometry
Open accessAbstract
In recent years, advances in technology have provided us with tools to quantify the expression of multiple genes in individual cells. The ability to simultaneously measure multiple genes on the same cell is necessary to resolve the incredible diversity of cell subsets, as well as to define their function in the host. Fluorescence-based flow cytometry is the benchmark for this; with it, we can quantify 18 proteins per cell, at >10,000 cells per second. “Mass cytometry” is a new technology that promises to significantly extend these capabilities. Immunophenotyping by mass spectrometry provides the ability to measure more than three dozen proteins at a rate of 1,000 cells per second. We review these cytometric technologies, capable of high-content, high-throughput single-cell assays.
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Cited by
Single-cell RNA sequencing to explore immune cell heterogeneity
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Self-citationMass Cytometry: Single Cells, Many Features
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Self-citationThe who's who of T ‐cell differentiation: Human memory T ‐cell subsets
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Self-citationCODEX multiplexed tissue imaging with DNA-conjugated antibodies
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Metadata
- Authors
- Bendall, S. C., Nolan, G. P., Roederer, M., & Chattopadhyay, P. K.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 33
- Issue
- 7
- Pages
- 323-332
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2015671099
- Cited by
- 656
- References
- 47
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
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