Dissecting negative regulation of Toll-like receptor signaling
Abstract
Toll-like receptors (TLRs) sense invading microbial pathogens and play crucial roles in the activation of innate and adaptive immunity. However, excessive TLR activation can disrupt immune homeostasis, and may be responsible for the development of autoimmune and inflammatory diseases. As such, the molecules and pathways that negatively control TLR signaling have been intensively investigated. Here, we discuss recent insights into the negative regulation of TLR signaling, with focus on three major mechanisms: (i) dissociation of adaptor complexes; (ii) degradation of signal proteins; and (iii) transcriptional regulation. We also highlight how pathogens negatively target TLR signaling as a strategy to evade the host immune response.
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Integrin-SYK signaling negatively regulates TLR signaling and the NFκB pathway by promoting degradation of MYD88.
“Integrin-SYK signaling is also responsible for negatively regulating Toll-like receptor (TLR) signaling and the NFκ B pathway by promoting the degradation of MYD88 (ref. 21).”
From Transcriptomic analysis of purified human cortical microglia reveals age-associated changes (2017) · cites this paper as [21]
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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
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- Authors
- Kondo, T., Kawai, T., & Akira, S.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 33
- Issue
- 9
- Pages
- 449-458
- ISSN
- 1471-4906
- Cited by
- 382
- References
- 6
- Language
- en
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health (P01 AI070167)
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