Cited by 238Immune Response and InflammationMicroRNA in disease regulationInflammasome and immune disorders

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

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He, Xiaobing, Jing, Zhizhong, Cheng, Guofeng·2014·BioMed Research International

Abstract

Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and homeostasis by elaborate modulatory mechanisms. MicroRNAs (miRNAs) have emerged as key regulators and as an essential part of the networks involved in regulating TLR-signalling pathways. In this review, we highlight our understanding of the regulation of miRNA expression profiles by TLR-signalling pathways and the regulation of TLR-signalling pathways by miRNAs. We focus on the roles of miRNAs in regulating TLR-signalling pathways by targeting multiple molecules, including TLRs themselves, their associated signalling proteins and regulatory molecules, and transcription factors and functional cytokines induced by them, at multiple levels.

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Crossref · 10.1155/2014/945169

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  • TLR signalling is regulated by microRNAs at multiple levels.

    “TLR signalling has also been shown to be regulated by microRNAs at multiple levels, such as by targeting TLRs, downstream signalling proteins, related regulatory molecules, transcription factors as well as genes induced by TLR signalling (e.g., cytokines), which was reviewed elsewhere [128].”

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2 of the 150 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. [2]He XB Jia HJ Jing ZZ Liu DX Recognition of pathogen-associated nucleic acids by the intracellular toll-like receptors Acta Biochimica et Biophysica Sinica 2013 45 4 240 257 PMC7109797 23369718
  2. [117]Hu G Zhou R Liu J Gong A-Y Chen X-M MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection Journal of Infectious Diseases 2010 202 1 125 135 2-s2.0-77953688418 20486857 PMC2880649
  3. [125]Filipowicz W Bhattacharyya SN Sonenberg N Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews Genetics 2008 9 2 102 114 2-s2.0-38349169664 18197166

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Authors
He, X., Jing, Z., & Cheng, G.
Affiliations
  • Lanzhou Veterinary Research Institute (CN)
  • Shanghai Veterinary Research Institute (CN)
Corresponding author
  • Jing, Zhizhong
  • Cheng, Guofeng
Venue
BioMed Research International
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-14
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W2066588601
Cited by
238
References
150
Citations by year
2026: 5 · 2025: 7 · 2024: 17 · 2023: 12 · 2022: 14 · 2021: 43 · 2020: 28 · 2019: 21 · 2018: 19 · 2017: 28 · 2016: 21 · 2015: 15 · 2014: 8
FWCI
2.34
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31302072, 31372423, 30871884)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords
microRNA, Toll-like receptors, innate immunity, pattern recognition receptors, miRNA expression regulation, microRNA target regulation, transcription factors, cytokines, tissue homeostasis
MeSH terms
Animals, Humans, Signal Transduction, MicroRNAs, Toll-Like Receptors

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