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Follicular dendritic cells: origin, phenotype, and function in health and disease

Aguzzi, Adriano, Kranich, Jan, Krautler, Nike Julia·2014·Trends in Immunology
DOI 10.1016/j.it.2013.11.001
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Abstract

Follicular dendritic cells (FDCs) were originally identified by their specific morphology and by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as well as the provision of chemokines, adhesion molecules, and trophic factors, FDCs participate in the shaping of B cell responses. Importantly, FDCs also supply tingible body macrophages (TBMs) with the eat-me-signaling molecule milk fat globule-EGF factor 8 (Mfge8), thereby enabling the disposal of apoptotic B cells. Recent studies have provided fundamental insights into the multiple functions of FDCs in both physiological and pathophysiological contexts and into their origin. Here we review these findings, and discuss current concepts related to FDC histogenesis both in lymphoid organs and in inflammatory lymphoneogenesis.

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Metadata

Authors
Aguzzi, A., Kranich, J., & Krautler, N. J.
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2014-03
Volume
35
Issue
3
Pages
105-113
ISSN
1471-4906
DOI
10.1016/j.it.2013.11.001
Cited by
176
References
2
Language
en

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