The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome
Open accessAbstract
The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to maturation of IL-1β and IL-18 and induction of a pro-inflammatory cell death in sentinel cells of the innate immune system. Diverse stimuli have been shown to activate the NLRP3 inflammasome during infection and metabolic diseases, thus implicating the pathway in triggering both adaptive and maladaptive inflammation in a variety of clinically important settings. Here I discuss the emerging model that signals associated with mitochondrial destabilization may critically activate the NLRP3 inflammasome. Together with studies indicating an important role for Ca2+ signaling, these findings suggest that many stimuli engage Ca2+ signaling as an intermediate step to trigger mitochondrial destabilization, thus generating the mitochondria-associated ligands that activate the NLRP3 inflammasome.
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Cites
A role for mitochondria in nlrp3 inflammasome activation
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
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Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849
The role of mitochondria in NLRP3 inflammasome activation
Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475
Endothelial barrier dysfunction in septic shock
Opal, S. M., & van der Poll, T. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12331 · Cited by 353
Neuroinflammation in Alzheimer’s Disease
Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330
Protein kinase D at the Golgi controls NLRP3 inflammasome activation
Zhang, Z., Meszaros, G., He, W.-T., Xu, Y., de Fatima Magliarelli, H., Mailly, L., Mihlan, M., Liu, Y., Puig Gámez, M., Goginashvili, A., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162040 · Cited by 282
Metadata
- Authors
- Horng, T.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 35
- Issue
- 6
- Pages
- 253-261
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2000117406
- Cited by
- 278
- References
- 14
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
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