The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Modulation of immune development and function by intestinal microbiota
Open accessAbstract
The host immune system must constantly monitor the gastrointestinal tract for the presence of pathogens, while tolerating trillions of commensal microbiota. The mechanisms that maintain intestinal immune homeostasis are not fully understood, but it is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relationship. Here we review recent findings on the ways in which intestinal microbiota shape immune development and responses. These have revealed that a range of microbiota derivatives can influence host immune functions, by targeting various cell types in the gut, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells and B and T lymphocytes. Although challenges remain, harnessing this knowledge could lead to new therapies for intestinal and systemic immune disorders.
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Cites
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Gomez de Agüero, M., Ganal-Vonarburg, S. C., Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., et al. (2016) · Science · doi:10.1126/science.aad2571 · Cited by 1,231
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
Kaiko, G. E., Ryu, S. H., Koues, O. I., Collins, P. L., Solnica-Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 733
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 522
Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis
Wen, C., Zheng, Z., Shao, T., Liu, L., Xie, Z., Le Chatelier, E., He, Z., Zhong, W., Fan, Y., Zhang, L., et al. (2017) · Genome Biology · doi:10.1186/s13059-017-1271-6 · Cited by 382
Sanchez, H. N., Moroney, J. B., Gan, H., Shen, T., Im, J. L., Li, T., Taylor, J. R., Zan, H., & Casali, P. (2020) · Nature Communications · doi:10.1038/s41467-019-13603-6 · Cited by 361
Metadata
- Authors
- Kabat, A. M., Srinivasan, N., & Maloy, K. J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 35
- Issue
- 11
- Pages
- 507-517
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2024285987
- Cited by
- 314
- References
- 144
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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