The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease
Open accessAbstract
The nervous system and the immune system are the principal sensory interfaces between the internal and external environment. They are responsible for recognizing, integrating, and responding to varied stimuli, and have the capacity to form memories of these encounters leading to learned or ‘adaptive’ future responses. Here, we review the current understanding of the cross-regulation between these systems. The autonomic and somatosensory nervous systems regulate both the development and deployment of immune cells, with broad functions that impact hematopoiesis as well as priming, migration and cytokine production. In turn, specific immune cell subsets contribute to homeostatic neural circuits such as those controlling metabolism, hypertension and the inflammatory reflex. We examine the contribution of the somatosensory system to autoimmune, autoinflammatory, allergic, and infectious processes in barrier tissues and in this context, discuss opportunities for therapeutic manipulation of neuro-immune interactions.
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Metadata
- Authors
- Ordovas-Montanes, J., Rakoff-Nahoum, S., Huang, S., Riol-Blanco, L., Barreiro, O., & von Andrian, U. H.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 36
- Issue
- 10
- Pages
- 578-604
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W1952419792
- Cited by
- 171
- References
- 22
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
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