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Cited by 35T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

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Lauvau, Grégoire, Boutet, Marie, Williams, Tere M., Chin, Shu Shien, Chorro, Laurent·2016·Trends in Immunology
DOI 10.1016/j.it.2016.04.001PMC PMC4885763
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Abstract

Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the mechanisms by which these cells mediate effective protection in vivo. The picture that emerges presents memory CD8(+) T cells as early sensors of danger signals, mediating protective immunity both through licensing of cellular effectors of the innate immune system and via the canonical functions associated with memory T cells. We discuss implications for the development of T cell vaccines and therapies and highlight important areas in need of further investigation.

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  • All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.

    “All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.26,27,28,29,30,31,32”

    From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [29]

    The Introduction identifies tissue-resident memory T cells as a memory CD8+ subset, and the ‘Sentinel cells’ section says inflammatory signals can reactivate memory CD8+ T cells without cognate antigen. But that section says circulating memory CD8+ cells mostly respond to those signals, while whether tissue-resident memory cells can respond to inflammatory cues alone remains unknown. The paper does not establish that all skin-resident T cells are pre-activated or have effector/memory-like phenotypes. Page numbers were not available in our copy. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Lauvau, G., Boutet, M., Williams, T. M., Chin, S. S., & Chorro, L.
Affiliations
Albert Einstein College of Medicine (US)
ORCID
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2016-06
Volume
37
Issue
6
Pages
375-385
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2016.04.001
PMC
PMC4885763
OpenAlex
W2342538488
Cited by
35
References
3
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 7
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (R01 103338, R21 095835)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
memory CD8+ T cells, innate-like T cells, mucosal immunity, T cell reactivation, damage-associated molecular patterns, T cell vaccines, T cell therapy
MeSH terms
Animals, Humans, Immunologic Memory, Intestinal Mucosa, Vaccines, Lymphocyte Subsets, Immunotherapy, Adoptive, CD8-Positive T-Lymphocytes, Immunity, Mucosal, Receptors, Pattern Recognition

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