Cited by 422Chemokine receptors and signalingImmune cells in cancerImmune Response and Inflammation

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Open access
Auffray, Cedric, Fogg, Darin K., Narni-Mancinelli, Emilie, Senechal, Brigitte, Trouillet, Celine, Saederup, Noah, Leemput, Julia, Bigot, Karine +8 more·2009·Journal of Experimental Medicine

Abstract

CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

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Crossref · 10.1084/jem.20081385

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  • Both CMP and GMP contain macrophage/dendritic cell precursors (MDP), confirmed by flow cytometry.

    “Gene expression patterns of Csf1r, Flt3 and Cx3cr1 suggested that both CMP and GMP contain macrophage/dendritic cell precursors (MDP: CX3CR1+CD115+CD135+)18, which was confirmed by flow cytometry (Extended Data Fig. 6d–f).”

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Authors
Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., Molina, T., Charo, I., Hume, D. A., Cumano, A., Lauvau, G., & Geissmann, F.
Affiliations
  • Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Santé et de la Recherche Médicale (INSERM) U838, Université Paris-Descartes, 75015 Paris, France 1
  • Inserm (FR)
  • INSERM U924, Université de Nice-Sophia Antipolis, 06560 Valbonne, France 2
  • University of California, San Francisco (US)
  • Université Paris Descartes (FR)
  • Roslin Institute (GB)
Venue
Journal of Experimental Medicine
Published
2009-03-09
Volume
206
Issue
3
Pages
595-606
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2142750845
Cited by
422
References
50
Citations by year
2026: 4 · 2025: 7 · 2024: 14 · 2023: 17 · 2022: 16 · 2021: 21 · 2020: 17 · 2019: 26 · 2018: 21 · 2017: 28 · 2016: 32 · 2015: 24 · 2014: 33 · 2013: 43 · 2012: 36
FWCI
19.67
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
  • HAL (submittedVersion, other-oa)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
CX3CR1, CSF1R, myeloid dendritic cells, plasmacytoid dendritic cells, monocytes, Listeria monocytogenes infection, monocyte recruitment, spleen, inflammation, myeloid development
MeSH terms
CX3C Chemokine Receptor 1, Animals, Bone Marrow Cells, Cell Differentiation, Cell Movement, Cell Survival, Dendritic Cells, Inflammation, Listeriosis, Listeria monocytogenes, Macrophages, Monocytes, Phenotype, Spleen, Stem Cells, Tumor Necrosis Factor-alpha, Receptor, Macrophage Colony-Stimulating Factor, Reactive Oxygen Species, Receptors, Chemokine, Cell Proliferation, Mice, fms-Like Tyrosine Kinase 3, Nitric Oxide Synthase Type II

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