The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Immune Dysfunction as a Cause and Consequence of Malnutrition
Open accessAbstract
Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect. Defects emerge before birth via modifications in the immunoepigenome of malnourished parents, and these may contribute to intergenerational cycles of malnutrition. This review summarizes key recent studies from experimental animals, in vitro models, and human cohorts, and proposes that immune dysfunction is both a cause and a consequence of malnutrition. Focusing on childhood undernutrition, we highlight gaps in current understanding of immune dysfunction in malnutrition, with a view to therapeutically targeting immune pathways as a novel means to reduce morbidity and mortality.
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Citations
Cites
Maternal and child undernutrition and overweight in low-income and middle-income countries
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The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease
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Dominguez-Salas, P., Moore, S. E., Baker, M. S., Bergen, A. W., Cox, S. E., Dyer, R. A., Fulford, A. J., Guan, Y., Laritsky, E., Silver, M. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4746 · Cited by 506
Cited by
The Human Microbiome and Child Growth – First 1000 Days and Beyond
Robertson, R. C., Manges, A. R., Finlay, B. B., & Prendergast, A. J. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2018.09.008 · Cited by 793
Self-citationThe impact of malnutrition on childhood infections
Walson, J. L., & Berkley, J. A. (2018) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000448 · Cited by 273
Self-citationThe Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
“This further exacerbates immune suppression and impaired growth while energy and micronutrients are diverted to acute-phase immune responses to combat multiple and often recurrent infections, leading to a chronic systemic inflammatory state and bacterial translocation (28).”
BackgroundA macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
Loft, A., Schmidt, S. F., Caratti, G., Stifel, U., Havelund, J., Sekar, R., Kwon, Y., Sulaj, A., Chow, K. K., Alfaro, A. J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.004 · Cited by 76
Choi, J., Lee, J., Kim, K., Choi, H.-K., Lee, S.-A., & Lee, H.-J. (2022) · Nutrients · doi:10.3390/nu14234982 · Cited by 53
Metadata
- Authors
- Bourke, C. D., Berkley, J. A., & Prendergast, A. J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 37
- Issue
- 6
- Pages
- 386-398
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2398393547
- Cited by
- 725
- References
- 18
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bourke, C. D., Berkley, J. A., & Prendergast, A. J. (2016). Immune Dysfunction as a Cause and Consequence of Malnutrition. Trends in Immunology. https://doi.org/10.1016/j.it.2016.04.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
