A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works

The Sequence Alignment/Map format and SAMtools

Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works

Fast and accurate short read alignment with Burrows-Wheeler transform

Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022 · see citing works

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works

Gene ontology analysis for RNA-seq: accounting for selection bias

Young, M. D., Wakefield, M. J., Smyth, G. K., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-2-r14 · Cited by 7,107 · see citing works

NicheNet: Modeling intercellular communication by linking ligands to target genes

Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods · doi:10.1038/s41592-019-0667-5 · Cited by 2,192 · see citing works

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,143 · see citing works

Mfuzz: A software package for soft clustering of microarray data

Kumar, L., & Futschik, M. E. (2007) · Bioinformation · doi:10.6026/97320630002005 · Cited by 2,000 · see citing works

New approach for understanding genome variations in KEGG

Kanehisa, M. I., Sato, Y., Furumichi, M., Morishima, K., & Tanabe, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky962 · Cited by 1,845 · see citing works

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Gao, G.-P., Alvira, M. R., Wang, L., Calcedo, R., Johnston, J., & Wilson, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182412299 · Cited by 1,520 · see citing works

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., & Magnuson, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.305 · Cited by 1,302 · see citing works

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

John, S., Sabo, P. J., Thurman, R. E., Sung, M.-H., Biddie, S. C., Johnson, T. A., Hager, G. L., & Stamatoyannopoulos, J. A. (2011) · Nature Genetics · doi:10.1038/ng.759 · Cited by 954 · see citing works

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Montagner, A., Polizzi, A., Fouché, E., Ducheix, S., Lippi, Y., Lasserre, F., Barquissau, V., Régnier, M., Lukowicz, C., Benhamed, F., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310798 · Cited by 746 · see citing works

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

Mo, A., Mukamel, E. A., Davis, F. P., Luo, C., Henry, G. L., Picard, S., Urich, M. A., Nery, J. R., Sejnowski, T. J., Lister, R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.018 · Cited by 739 · see citing works

Immune Dysfunction as a Cause and Consequence of Malnutrition

Bourke, C. D., Berkley, J. A., & Prendergast, A. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.003 · Cited by 732 · see citing works

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

Grimm, D., Kern, A., Rittner, K., & Kleinschmidt, J. A. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.18-2745 · Cited by 700 · see citing works

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579 · see citing works

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Huang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520 · see citing works

Kupffer Cells Promote Hepatic Steatosis Via Interleukin-1β–Dependent Suppression of Peroxisome Proliferator-Activated Receptor α Activity

Stienstra, R., Saudale, F., Duval, C., Keshtkar, S., Groener, J. E. M., van Rooijen, N., Staels, B., Kersten, S., & Müller, M. (2010) · Hepatology · doi:10.1002/hep.23337 · Cited by 452 · see citing works

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

Jordan, S., Tung, N., Casanova-Acebes, M., Chang, C., Cantoni, C., Zhang, D., Wirtz, T. H., Naik, S., Rose, S. A., Brocker, C. N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.050 · Cited by 440 · see citing works

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

Nathwani, A. C., Gray, J. T., Ng, C. Y., Zhou, J., Spence, Y., Waddington, S. N., Tuddenham, E. G. D., Kemball‐Cook, G., McIntosh, J., Boon‐Spijker, M., et al. (2005) · Blood · doi:10.1182/blood-2005-10-4035 · Cited by 421 · see citing works

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.002 · Cited by 418 · see citing works

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.

Feingold, K. R., & Grünfeld, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113046 · Cited by 403 · see citing works

A Simple Method for Gene Expression and Chromatin Profiling of Individual Cell Types within a Tissue

Deal, R. B., & Henikoff, S. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.013 · Cited by 379 · see citing works

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

Peng, W. C., Logan, C. Y., Fish, M., Anbarchian, T., Aguisanda, F., Álvarez-Varela, A., Wu, P., Jin, Y., Zhu, J., Li, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.012 · Cited by 331 · see citing works

Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data

Qin, Q., Fan, J., Zheng, R., Wan, C., Mei, S., Wu, Q., Sun, H., Zhang, J., Brown, M., Meyer, C. A., et al. (2020) · Genome biology · doi:10.1186/s13059-020-1934-6 · Cited by 287 · see citing works

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

Ganeshan, K., Nikkanen, J., Man, K., Leong, Y. A., Sogawa, Y., Maschek, J. A., Van Ry, T., Chagwedera, D. N., Cox, J. E., & Chawla, A. (2019) · Cell · doi:10.1016/j.cell.2019.01.050 · Cited by 286 · see citing works

Metabolic adaptation establishes disease tolerance to sepsis

Weis, S., Carlos, A. R., Moita, M. R., Singh, S., Blankenhaus, B., Cardoso, S., Larsen, R., Rebelo, S., Schäuble, S., Del Barrio, L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.031 · Cited by 284 · see citing works

Kupffer cell activation is a causal factor for hepatic insulin resistance

Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 258 · see citing works

Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase

Bhattacharyya, S., Brown, D. E., Brewer, J. A., Vogt, S. K., & Muglia, L. J. (2007) · Blood · doi:10.1182/blood-2006-10-048215 · Cited by 249 · see citing works

Inactivation of the Glucocorticoid Receptor in Hepatocytes Leads to Fasting Hypoglycemia and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetes Mellitus

Opherk, C., Tronche, F., Kellendonk, C., Kohlmüller, D., Schulze, A., Schmid, W., & Schütz, G. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0283 · Cited by 207 · see citing works

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A., Madsen, J., Larsen, M., Forss, I., Madsen, M. R., Hauwaert, E. L. V., Wiwie, C., Jespersen, N., Tencerova, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0359-1 · Cited by 202 · see citing works

GIGGLE: a search engine for large-scale integrated genome analysis

Layer, R. M., Pedersen, B. S., DiSera, T., Marth, G., Gertz, J., & Quinlan, A. R. (2018) · Nature Methods · doi:10.1038/nmeth.4556 · Cited by 197 · see citing works

Glucocorticoid receptor dimerization is required for survival in septic shock <i>via</i> suppression of interleukin‐1 in macrophages

Kleiman, A., Hübner, S., Parkitna, J. M. R., Neumann, A., Hofer, S., Weigand, M. A., Bauer, M., Schmid, W., Schütz, G., Libert, C., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-192112 · Cited by 152 · see citing works

Hepatocyte-Macrophage Acetoacetate Shuttle Protects Against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J., & Crawford, P. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.015 · Cited by 138 · see citing works

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.005 · Cited by 129 · see citing works

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

Goldstein, I., Baek, S., Presman, D. M., Paakinaho, V., Swinstead, E. E., & Hager, G. L. (2017) · Genome Research · doi:10.1101/gr.212175.116 · Cited by 121 · see citing works

Transcriptional and Chromatin Regulation during Fasting – The Genomic Era

Goldstein, I., & Hager, G. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.005 · Cited by 110 · see citing works

Molecular Control of Systemic Bile Acid Homeostasis by the Liver Glucocorticoid Receptor

Rose, A. J., Díaz, M. B., Reimann, A., Klement, J., Walcher, T., Krones, A., Strobel, O., Werner, J. M., Peters, A., Kleyman, A., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.010 · Cited by 94 · see citing works

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Paumelle, R., Haas, J. T., Hennuyer, N., Baugé, E., Deleye, Y., Mesotten, D., Langouche, L., Vanhoutte, J., Cudejko, C., Wouters, K., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.12.037 · Cited by 90 · see citing works

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Wyngene, L. V., Vanderhaeghen, T., Timmermans, S., Vandewalle, J., Looveren, K. V., Souffriau, J., Wallaeys, C., Eggermont, M., Ernst, S., Hamme, E. V., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911319 · Cited by 75 · see citing works

iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data

Madsen, J., Schmidt, S., Larsen, B. D., Loft, A., Nielsen, R., & Mandrup, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1365 · Cited by 74 · see citing works

Integrated analysis of motif activity and gene expression changes of transcription factorsPreprint

Madsen, J. G. S., Rauch, A., Hauwaert, E. L. V., Schmidt, S. F., Winnefeld, M., & Mandrup, S. (2017) · Genome Research · doi:10.1101/gr.227231.117 · Cited by 72 · see citing works

Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era

Gerber, A. N., Newton, R. C., & Sasse, S. K. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100687 · Cited by 72 · see citing works

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Dendoncker, K., Timmermans, S., Vandewalle, J., Eggermont, M., Lempiäinen, J. K., Paakinaho, V., Hamme, E. V., Dewaele, S., Vandevyver, S., Ballegeer, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821565116 · Cited by 71 · see citing works

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Ratman, D., Mylka, V., Bougarne, N., Pawlak, M., Caron, S., Hennuyer, N., Paumelle, R., Cauwer, L. D., Thommis, J., Rider, M. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw742 · Cited by 70 · see citing works

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

Mueller, K. M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., et al. (2016) · Diabetes · doi:10.2337/db16-0381 · Cited by 66 · see citing works

Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver

He, B., Cruz‐Topete, D., Oakley, R. H., Xiao, X., & Cidlowski, J. A. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00908-15 · Cited by 64 · see citing works

Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring

Okawa, T., Nagai, M., & Hase, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.623989 · Cited by 64 · see citing works

Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia

Kulozik, P., Jones, A., Mattijssen, F., Rose, A. J., Reimann, A., Strzoda, D., Kleinsorg, S., Raupp, C., Kleinschmidt, J. A., Müller‐Decker, K., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.011 · Cited by 60 · see citing works

Cofactor squelching: Artifact or fact?

Schmidt, S. F., Larsen, B. D., Loft, A., & Mandrup, S. (2016) · BioEssays · doi:10.1002/bies.201600034 · Cited by 56 · see citing works

TNF‐α and IL‐6 Synergistically Inhibit Ketogenesis From Fatty Acids and α‐Ketoisocaproate in Isolated Rat Hepatocytes

Pailla, K., Lim, S.-K., Bandt, J. P. D., Aussel, C., GIBOUDEAU, J., Troupel, S., Cynober, L., & Blondé-Cynober, F. (1998) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607198022005286 · Cited by 14 · see citing works

Inhibition of hepatic ketogenesis by tumor necrosis factor-alpha in rats

Beylot, M., Vidal, H., Mithieux, G., Odeon, M., & Martin, C. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.5.e897 · Cited by 12 · see citing works

Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing

Loft, A., Herzig, S., & Schmidt, S. F. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100805 · Cited by 11 · see citing works

Metabolic reprogramming in liver fibrosis

Horn, P., & Tacke, F. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.003 · Cited by 432 · see citing works

Liver diseases: epidemiology, causes, trends and predictions

Gan, C., Yuan, Y., Shen, H., Gao, J., Kong, X., Che, Z., Guo, Y., Wang, H., Dong, E., & Xiao, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02072-z · Cited by 370 · see citing works

Transcriptional control of energy metabolism by nuclear receptors

Scholtes, C., & Giguère, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00486-7 · Cited by 129 · see citing works

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.

Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Aicher, D., Gopalsamy, I. K., Fong, W., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.015 · Cited by 122 · see citing works

Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting

Ruppert, P. M. M., & Kersten, S. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.002 · Cited by 97 · see citing works

Macrophage and T cell networks in adipose tissue

Jacks, R. D., & Lumeng, C. N.-K. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00908-2 · Cited by 77 · see citing works

Macrophages and T cells in metabolic disorder-associated cancers

Taranto, D., Kloosterman, D., & Akkari, L. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 67 · see citing works

Physiological role of cytokines in the regulation of mammalian metabolism

Baat, A. D., Trinh, B., Ellingsgaard, H., & Donath, M. Y. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.06.002 · Cited by 58 · see citing works

ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway

Shi, R., Wang, J., Zhang, Z., Leng, Y., & Chen, A. F. (2023) · Life Sciences · doi:10.1016/j.lfs.2022.121339 · Cited by 57 · see citing works

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting

Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 54 · see citing works

Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance

Caratti, G., Stifel, U., Caratti, B., Jamil, A. J. M., Chung, K., Kiehntopf, M., Gräler, M. H., Blüher, M., Rauch, A., & Tuckermann, J. P. (2023) · Nature Communications · doi:10.1038/s41467-023-37831-z · Cited by 51 · see citing works

The Role of Intermittent Fasting in the Management of Nonalcoholic Fatty Liver Disease: A Narrative Review

Lavallee, C. M., Bruno, A., Ma, C., & Raman, M. (2022) · Nutrients · doi:10.3390/nu14214655 · Cited by 44 · see citing works

Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data

Sang-aram, C., Browaeys, R., Seurinck, R., & Saeys, Y. (2025) · Nature Protocols · doi:10.1038/s41596-024-01121-9 · Cited by 44 · see citing works

Intermittent fasting—the future treatment in NASH patients?

Minciună, I., Gallage, S., Heikenwälder, M. F., Zelber‐Sagi, S., & Dufour, J. (2023) · Hepatology · doi:10.1097/hep.0000000000000330 · Cited by 31 · see citing works

Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice

Ding, J., Xu, M. J., Du, W., Fang, Z., Xu, H., Liu, J., Song, P., Chen, X., Li, Z., Yue, Z., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80122 · Cited by 29 · see citing works

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

Preković, S., Chalkiadakis, T., Roest, M., Roden, D. L., Lutz, C., Schuurman, K. G., Opdam, M., Hoekman, L., Abbott, N., Tesselaar, T., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317737 · Cited by 24 · see citing works

Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes

Crespo, M. T., Trebucq, L. L., Senna, C. A., Hokama, G., Paladino, N., Agostino, P. V., & Chiesa, J. J. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100827 · Cited by 24 · see citing works

Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

Lambrecht, R., Delgado, M. E., Gloe, V., Schuetz, K., Plazzo, A. P., Franke, B., Phan, T. S., Fleming, J. R., Mayans, O. M., & Brunner, T. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113513 · Cited by 23 · see citing works

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

Antwi, M. B., Jennings, A., Lefere, S., Clarisse, D., Geerts, A. M., Devisscher, L., & Bosscher, K. D. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00013-6 · Cited by 22 · see citing works

miR-301a Deficiency Attenuates the Macrophage Migration and Phagocytosis through YY1/CXCR4 Pathway

Xu, J., Fu, L., Deng, J., Zhang, J., Zou, Y., Liao, L., Ma, X., Li, Z., Xu, Y., Xu, Y., et al. (2022) · Cells · doi:10.3390/cells11243952 · Cited by 19 · see citing works

Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy

Chen, C., Han, P., & Qing, Y. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103579 · Cited by 17 · see citing works

EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor

Quagliarini, F., Makris, K., Friano, M. E., & Uhlenhaut, N. H. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad048 · Cited by 18 · see citing works

Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Hamilton, M. C., Fife, J. D., Akıncı, E., Yu, T., Khowpinitchai, B., Cha, M., Barkal, S. A., Thi, T. T., Yeo, G. H. T., Barroso, J. P. R., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100304 · Cited by 16 · see citing works

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Xia, H., Dufour, C. R., Medkour, Y., Scholtes, C., Chen, Y., Guluzian, C., B'Chir, W., & Giguère, V. (2023) · Nature Communications · doi:10.1038/s41467-023-42785-3 · Cited by 16 · see citing works

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Lü, H. (2024) · Clinical Science · doi:10.1042/cs20230522 · Cited by 17 · see citing works

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Minciună, I., van Kleef, L. A., Ştefănescu, H., & Procopeț, B. (2022) · Cancers · doi:10.3390/cancers14205084 · Cited by 13 · see citing works

Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway

Xu, F., Xiao, Y., Guo, Q., Peng, H., Zhou, H., Wang, J., & Xia, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.899731 · Cited by 12 · see citing works

Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice

Correia, C. M., Præstholm, S. M., Havelund, J. F., Pedersen, F. B., Siersbæk, M. S., Ebbesen, M. F., Gerhart‐Hines, Z., Heeren, J., Brewer, J. R., Larsen, S., et al. (2023) · Endocrinology · doi:10.1210/endocr/bqad128 · Cited by 12 · see citing works

Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

Sen, D., Maniyadath, B., Chowdhury, S., Kaur, A., Khatri, S., Chakraborty, A., Mehendale, N., Nadagouda, S., Sandra, U. S., Kamat, S. S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107128 · Cited by 10 · see citing works

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, S., Masson, J. J. R., Ferrari-Cestari, M., Bodea, L., Nooru‐Mohamed, F., Tse, B. W.-C., Sokolowski, K. A., Batoon, L., Patkar, O. L., Sullivan, M. A., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00347.2023 · Cited by 10 · see citing works

Effects of intermittent calorie restriction in nondiabetic patients with metabolic dysfunction-associated steatotic liver disease

Lee, H. A., Moon, H., Kim, Y., Lee, J. K., Lee, H. A., & Kim, H. Y. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.06.051 · Cited by 9 · see citing works

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Li, S., Ye, T., Hou, Z., Wang, Y., Hao, Z., & Chen, J. W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107691 · Cited by 9 · see citing works

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Chen, Y., & Tang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050188 · Cited by 9 · see citing works

New insights into cellular links between sodium–glucose cotransporter‐2 inhibitors and ketogenesis

Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30327 · Cited by 9 · see citing works

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

Goldberg, D. T., Buchshtab, N., Charni‐Natan, M., & Goldstein, I. (2024) · Liver International · doi:10.1111/liv.16077 · Cited by 7 · see citing works

Fasting as an Adjuvant Therapy for Cancer: Mechanism of Action and Clinical Practice

Xie, Y., Ye, H., Liu, Z., Liang, Z., Zhu, J., Zhang, R., & Li, Y. (2024) · Biomolecules · doi:10.3390/biom14111437 · Cited by 11 · see citing works

Cohort profile of the Heidelberg study on diabetes and complications HEIST-DiC

Kliemank, E., von Rauchhaupt, E., Seebauer, L., Roshan, M., Ansmann, M., Flegka, V., Schimpfle, L., Tsilingiris, D., Bartl, H., Fleming, T. H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-15343-8 · Cited by 6 · see citing works

Pro-aging effects of chronic glucocorticoid signaling

Lambertucci, F., Castinetti, F., Martins, I., López-Otı́n, C., & Kroemer, G. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.05.002 · Cited by 7 · see citing works

One potential hotspot SLC25A20 gene variants in Chinese patients with carnitine-acylcarnitine translocase deficiency

Li, X., & Shen, J. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1029004 · Cited by 6 · see citing works

Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver

Wang, S., Xu, B., Liang, J., Feng, Y., Han, P., Shen, J., Li, X., Zheng, M., Zhang, T., Zhang, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202405240 · Cited by 5 · see citing works

Fe-capsaicin nanozyme attenuates sepsis-induced acute lung injury by regulating the functions of macrophages

Wang, R., Zhou, N., Xue, J., Yan, L., Wang, Y., Zhu, H., & Lv, C. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1509136 · Cited by 5 · see citing works

Tools for regulating metabolic diseases: extracellular vesicles from adipose macrophages

Zhang, L., Lou, K., Zhang, Y., Leng, Y., Huang, Y., Liao, X., Liu, X., Feng, S., & Feng, G. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1510712 · Cited by 4 · see citing works

Effects of Calorie Restriction and Fasting on Macrophage: Potential Impact on Disease Outcomes?

Wang, L., Wang, R., Yu, X., Shi, Y., Li, S., & Yuan, Y. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300380 · Cited by 4 · see citing works

Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences

Goldberg, D. T., & Goldstein, I. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01228-3 · Cited by 7 · see citing works

Exploring recent insights on intermittent fasting in regulating glucocorticoid levels and diet-induced metabolic disorders with focus on MAFLD and hepatic outcomes

Elechi, J. O. G., de Mendonça, C. R., Bandeira, V. C. D. A., da Silva, M. S. P., de Melo, A. P. R., Guedes, R. C. A., Hirabara, S. M., Cione, E., & de Vasconcelos, D. A. A. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112736 · Cited by 4 · see citing works

Kupffer cells: Orchestrators of liver physiology

Qin, C., Chen, Y., & Tang, L. (2026) · Liver Research · doi:10.1016/j.livres.2026.01.004 · Cited by 3 · see citing works

Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis

Tu, T., Alba, M. M., Datta, A. A., Hong, H., Hua, B., Jia, Y., Khan, J., Nguyen, P., Niu, X., Pammidimukkala, P., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.958696 · Cited by 3 · see citing works

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesPreprint

Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Kosla, J., Li, X., Focaccia, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.562885 · Cited by 3 · see citing works

Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells

Bockmann, J., Allweiss, L., Volmari, A., Araújo, D. D. F., Kohsar, M., Hyrina, A., Kah, J., Song, Z., Chan, J., Giersch, K., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101273 · Cited by 2 · see citing works

Methanobrevibacter smithii induces postnatal growth retardation through blunting hepatic ketone body metabolism

Qi, M., Song, T., Deng, Y., Li, N., Wang, N., Zha, A., Ye, Q., Wang, C., Shao, Y., Zhu, Y., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.11.039 · Cited by 2 · see citing works

Targeting immunometabolism in cancer through pharmacological and lifestyle interventions

Tan, R. J. Y., Liu, Y., Chen, W., Liang, Y., & Ling, G. S. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003617 · Cited by 2 · see citing works

Energy saver: Monocytes hibernate in bone marrow upon fasting

Tuckermann, J. P., & Fischer‐Posovszky, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.008 · Cited by 2 · see citing works

Ketogenesis nutritionally supports brain during bacterial infection in Drosophila

Krejčová, G., Novotná, D., & Bajgar, A. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.01.008 · Cited by 2 · see citing works

Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion

Sha, Z., Yang, K., Fu, S., Tong, X., Yang, H., Fang, H., He, Q., Li, N., Shu, X., Liu, Q., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71791-4 · Cited by 1 · see citing works

Characterization of three lamp genes from largemouth bass (Micropterus salmoides): molecular cloning, expression patterns, and their transcriptional levels in response to fast and refeeding strategy

Yang, Y., Zeng, W.-H., Peng, Y., Zuo, S.-Y., Fu, Y., Xiao, Y.-M., Huang, W.-L., Wen, Z., Hu, W., Yang, Y.-Y., et al. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1386413 · Cited by 1 · see citing works

Fasting-regulated mechanisms in inter-organ crosstalk

Alfaro, A. J., & Herzig, S. (2024) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2024.100540 · Cited by 1 · see citing works

Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism

Lucibello, G., Ursino, G., Teixeira, P. D. S., Zahorán, S., Fanuele, F., Kallikourdis, M., Visentin, F., Veyrat‐Durebex, C., Widmer, A., Wu, Y., et al. (2025) · Endocrinology · doi:10.1210/endocr/bqaf131 · Cited by 1 · see citing works

A temporal dialogue between the circadian clock and chronic inflammatory diseases

Chen, S., & Ray, D. W. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052749 · Cited by 1 · see citing works

Metabolic inflammation, obesity, and cancer

Alzaïd, F., Blériot, C., Anagnostopoulos, G., Chakarov, S., Venteclef, N., & Ginhoux, F. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.020 · Cited by 1 · see citing works

Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish

Hang, M., Tse, M. C. L., Pang, B. P. S., Bi, X., Jin, F., Lee, C. W., Wong, A., & Chan, C. B. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114372 · Cited by 1 · see citing works

Caloric restriction impacts skin barrier function and attenuates the development of hyperplasia skin disease

Tang, H., Li­, ­., Jin, M., Li, C., Zhai, C., Wang, J., Huang, T., & Ding, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1423524 · Cited by 1 · see citing works

Intermittent fasting versus continuous energy restriction in MASLD: a systematic review and meta-analysis

Li, H., & Li, T. (2026) · Frontiers in nutrition · doi:10.3389/fnut.2026.1833688 · Cited by 1 · see citing works

Hungerstoffwechsel – Von molekularen Grundlagen bis zur therapeutischen Nutzung – Werner-Creutzfeldt-Preis 2022 – eine Kurzübersicht des Preisträgers Stephan Herzig

Herzig, S. (2022) · Diabetologie und Stoffwechsel · doi:10.1055/a-1925-2707

Zeitlich eingeschränkte Nahrungsaufnahme

Szendroedi, J., & Sulaj, A. (2022) · Info Diabetologie · doi:10.1007/s15034-022-4438-5

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic metabolism to fuel liver growthPreprint

Keshvari, S., Masson, J. J. R., Ferrari-Cestari, M., Bodea, L., Nooru‐Mohamed, F., Tse, B. W.-C., Sokolowski, K. A., Batoon, L., Patkar, O. L., Sullivan, M. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.538022

Research Progress of Monocytes-Macrophages on Regulation of Lipid Metabolism

冯, 睿. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142544

Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages

Anagnostopoulos, G., Blériot, C., Venteclef, N., & Ginhoux, F. (2024) · Results and problems in cell differentiation · doi:10.1007/978-3-031-65944-7_3

Risk factors for postoperative pneumonia following thoracoscopic lobectomy: a retrospective study with a focus on preoperative fasting duration

Lin, H., Tang, Y., Zhou, S., Huang, W. C., Hu, L., & Jin, L. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-03516-x

Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages

Spahn, A. S., Rian, K., Gidon, A., Louet, C., Boyartchuk, V., Flo, T. H., & Anthonsen, M. W. (2026) · NAR Molecular Medicine · doi:10.1093/narmme/ugag017

The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism

Xu, Q.-Y., Zhang, J., Wan, X., Ling, W., Yang, J.-C., & Yan, L. (2026) · Military Medical Research · doi:10.1016/j.mmr.2026.100037

Characterization of a novel synthetic constitutive-active glucocorticoid receptor

Lu, H., Fahy, C., & Wang, G. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.107044

Intermediate filament protein vimentin propels intrahepatic lipid accumulation in insulin-resistant mice

Rawat, P., Thakur, S., Jaswal, K., Sen, A., Biswal, A., Dehury, B., & Mondal, P. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113265

Nocturnal Dim Blue Light Is Associated with Splenic Immune Dysregulation and Altered CORT-GR Signalling in High-Fat-Diet-Fed Mice

Shi, H., Guan, Q., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2026) · Antioxidants · doi:10.3390/antiox15070800

Ketogenesis as a Metabolic Checkpoint in MASLD: Implications for Disease Progression and Therapy

Babu, A. F. (2026) · Metabolites · doi:10.3390/metabo16090659

Glucocorticoid Receptor Alpha as an Integrative Regulator of Host Defense: A Systems-Level Review and Framework for Immune Regulation and Homeostatic Correction

Meduri, G. U. (2026) · Biomedicines · doi:10.3390/biomedicines14102313

Molekulare Charakterisierung und therapeutische Nutzung des Hunger- und Fastenstoffwechsels

Herzig, S. (2026) · Diabetologie und Stoffwechsel · doi:10.1055/a-2884-7415

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

Longuet, C., Sinclair, E. M., Maida, A., Baggio, L. L., Maziarz, M., Charron, M. J., & Drucker, D. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.008 · Cited by 272 · see citing works

Cell Metabolism Article The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

Longuet, C., Sinclair, E. M., Maida, A., Baggio, L. L., Maziarz, M., & Charron, M. J. (2013)

GR‐KLF15 pathway controls hepatic lipogenesis during fasting

Takeuchi, Y., Murayama, Y., Aita, Y., Saber, Z. M., Karkoutly, S., Tao, D., Katabami, K., Ye, C., Shikama, A., Masuda, Y., et al. (2023) · FEBS Journal · doi:10.1111/febs.16957 · Cited by 16 · see citing works

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

Goldberg, D. T., Buchshtab, N., Charni‐Natan, M., & Goldstein, I. (2024) · Liver International · doi:10.1111/liv.16077 · Cited by 7 · see citing works

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

Goldstein, I., Baek, S., Presman, D. M., Paakinaho, V., Swinstead, E. E., & Hager, G. L. (2017) · Genome Research · doi:10.1101/gr.212175.116 · Cited by 121 · see citing works