The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Tissue-Specific Immunity at the Oral Mucosal Barrier
Open accessAbstract
The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune control, including a diverse commensal microbiome, ongoing damage from mastication, and dietary and airborne antigens. However, how these tissue-specific cues participate in the training of immune responsiveness at this site is minimally understood. Moreover, the mechanisms mediating homeostatic immunity at this interface are not yet fully defined. Here we present basic aspects of the oral mucosal barrier and discuss local cues that may modulate and train local immune responsiveness. We particularly focus on the immune cell network mediating immune surveillance at a specific oral barrier, the gingiva - a constantly stimulated and dynamic environment where homeostasis is often disrupted, resulting in the common inflammatory disease periodontitis.
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Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · cited 1×
“Early studies in which healthy volunteers abstained from oral hygiene have demonstrated that increases and shifts in microbial populations [42] led to clinically detectable gingival inflammation [43].”
BackgroundDewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
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A review of saliva: Normal composition, flow, and function
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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
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Cited by
Dutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0797 · Cited by 382
“It is the initial portal of encounter for microbes, food, and airborne antigens as they enter the GI tract, all in the context of mechanical stress (mastication) (27).”
Self-citationHajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 281
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis
Aggor, F. E. Y., Break, T. J., Trevejo-Nuñez, G., Whibley, N., Coleman, B. M., Bailey, R. D., Kaplan, D. H., Naglik, J. R., Shan, W., Shetty, A. C., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba0570 · Cited by 119
Review: modulation of the oral microbiome by the host to promote ecological balance
Cornejo Ulloa, P., van der Veen, M. H., & Krom, B. P. (2019) · Odontology · doi:10.1007/s10266-019-00413-x · Cited by 104
C1R mutations trigger constitutive complement 1 activation in periodontal Ehlers-Danlos syndrome
Gröbner, R., Kapferer-Seebacher, I., Amberger, A., Redolfi, R., Dalonneau, F., Björck, E., Milnes, D., Bally, I., Rossi, V., Thielens, N., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02537 · Cited by 35
Metadata
- Authors
- Moutsopoulos, N. M., & Konkel, J. E.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 39
- Issue
- 4
- Pages
- 276-287
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2752951686
- Cited by
- 409
- References
- 99
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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