A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans
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Combined patient and animal model studies implicate microbiota-triggered T H 17 cells as disease drivers and therapeutic targets in periodontitis.
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Studies using germ-free mice have demonstrated the role of diabetes in disrupting the equilibrium of the oral microbiota and confirmed the role of the oral microbiota in periodontal disease pathogenesis.
“Studies using germ‐free mice have also been employed in the context of the oral microbiome, demonstrating the role of diabetes in disrupting the equilibrium of the oral microbiota50 and confirming the role of the oral microbiota in periodontal disease pathogenesis.51, 52”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [52]
Functions of immune networks within oral mucosa reflect the site-specific challenges faced within the oral cavity; they contribute to homeostasis in response to masticatory forces and trigger immune responses to the development of pathologic microbial communities.
“In line with the role of oral mucosa as a physiological barrier, the functions of immune networks within this mucosa reflect the site‐specific challenges faced within the oral cavity. For example, they contribute to homeostasis in response to masticatory forces and trigger immune responses to the development of pathologic microbial communities.52, 53”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [52]
Microbial dysbiosis is also necessary for additional inflammatory responses characteristic of periodontal disease, including local expansion of pathologic interleukin-17+/CD4+ T-helper (T-helper 17) cells.
“Microbial dysbiosis is also necessary for additional inflammatory responses characteristic of periodontal disease, including local expansion of pathologic interleukin‐17+/CD4+ T‐helper (T‐helper 17) cells.52”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [52]
The importance of commensal species to pathogenesis is further demonstrated by the requirement for commensal microbial communities in the instigation of disease by periodontal pathogens.
“The importance of commensal species to pathogenesis is further demonstrated by the requirement for commensal microbial communities in the instigation of disease by periodontal pathogens.51, 52”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [52]
In an additional study, homeostatic T-helper 17 cells were induced by mechanical stimuli in a microbiome-independent manner, whereas periodontitis-associated T-helper 17 cells accumulated in a microbiome-dependent manner and required both interleukin-6 and interleukin-23.
“homeostatic T‐helper 17 cells were found to be induced by mechanical stimuli in a microbiome‐independent manner, whereas periodontitis‐associated T‐helper 17 cells were found to accumulate in a microbiome‐dependent manner and to require both interleukin‐6 and interleukin‐23.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [52]
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Cites
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046 · see citing works
Self-citationPeriodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688 · see citing works
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585 · see citing works
Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 – 2012
Eke, P., Dye, B., Wei, L., Slade, G., Thornton-Evans, G., Borgnakke, W., Taylor, G., Page, R., Beck, J., & Genco, R. (2015) · The Journal of Periodontology · doi:10.1902/jop.2015.140520 · Cited by 1,442 · see citing works
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414 · see citing works
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works
Self-citationSTAT3 Mutations in the Hyper-IgE Syndrome
Holland, S. M., DeLeo, F. R., Elloumi, H. Z., Hsu, A. P., Uzel, G., Brodsky, N. N., Freeman, A. F., Demidowich, A. P., Davis, J., Turner, M. L. C., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073687 · Cited by 1,214 · see citing works
Self-citationInduction and molecular signature of pathogenic TH17 cells
Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2416 · Cited by 1,174 · see citing works
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works
Self-citationAbusleme, L., Dupuy, A. K., Dutzan, N., Silva, N., Burleson, J. A., Strausbaugh, L. D., Gamonal, J. A., & Diaz, P. I. (2013) · The ISME Journal · doi:10.1038/ismej.2012.174 · Cited by 1,102 · see citing works
Self-citationCompartmentalized Control of Skin Immunity by Resident Commensals
Naik, S., Bouladoux, N., Wilhelm, C., Molloy, M. J., Salcedo, R., Kastenmuller, W., Deming, C., Quinones, M., Koo, L., Conlan, S., et al. (2012) · Science · doi:10.1126/science.1225152 · Cited by 1,092 · see citing works
Self-citationChronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., et al. (2011) · Science · doi:10.1126/science.1200439 · Cited by 1,056 · cited 1× · see citing works
“Specifically, patients with primary immunodeficiencies affecting either TH17 cell differentiation or function (12, 13) all have susceptibility to oral candidiasis.”
Griffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P., Yang, Z. K., Podar, M., & Leys, E. J. (2011) · The ISME Journal · doi:10.1038/ismej.2011.191 · Cited by 1,006 · see citing works
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848 · see citing works
IL-17 Signaling: The Yin and the Yang
Amatya, N., Garg, A. V., & Gaffen, S. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.006 · Cited by 785 · see citing works
Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
Lee, J. S., Tato, C. M., Joyce-Shaikh, B., Gulen, M. F., Cayatte, C., Chen, Y., Blumenschein, W. M., Judo, M., Ayanoglu, G., McClanahan, T. K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.003 · Cited by 760 · see citing works
Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
Durant, L. R., Watford, W. T., Ramos, H. L., Laurence, A. D. J., Vahedi, G., Wei, L., Takahashi, H., Sun, H., Kanno, Y., Powrie, F. M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.003 · Cited by 722 · see citing works
Neutrophils as protagonists and targets in chronic inflammation
Soehnlein, O., Steffens, S., Hidalgo, A., & Weber, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.10 · Cited by 606 · see citing works
Polymicrobial synergy and dysbiosis in inflammatory disease
Lamont, R. J., & Hajishengallis, G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.004 · Cited by 585 · see citing works
Self-citationOptimization of the ligature-induced periodontitis model in mice
Abe, T., & Hajishengallis, G. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.05.002 · Cited by 550 · see citing works
Self-citationFocused specificity of intestinal TH17 cells towards commensal bacterial antigens
Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520 · see citing works
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 477 · see citing works
Self-citationInterleukin 17 is a chief orchestrator of immunity
Veldhoen, M. (2017) · Nature Immunology · doi:10.1038/ni.3742 · Cited by 474 · see citing works
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
Eskan, M. A., Jotwani, R., Abe, T., Chmelar, J., Lim, J.-H., Liang, S., Ciero, P. A., Krauss, J. L., Li, F., Rauner, M., et al. (2012) · Nature Immunology · doi:10.1038/ni.2260 · Cited by 429 · see citing works
Self-citationTissue-Specific Immunity at the Oral Mucosal Barrier
Moutsopoulos, N. M., & Konkel, J. E. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.005 · Cited by 401 · see citing works
Self-citationThe dichotomous nature of T helper 17 cells
Stockinger, B., & Omenetti, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.50 · Cited by 399 · see citing works
Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity
Xiao, E., Mattos, M., Vieira, G. H. A., Chen, S., Corrêa, J. D., Wu, Y., Albiero, M. L., Bittinger, K., & Graves, D. T. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.014 · Cited by 396 · see citing works
Host defense against oral microbiota by bone-damaging T cells
Tsukasaki, M., Komatsu, N., Nagashima, K., Nitta, T., Pluemsakunthai, W., Shukunami, C., Iwakura, Y., Nakashima, T., Okamoto, K., & Takayanagi, H. (2018) · Nature Communications · doi:10.1038/s41467-018-03147-6 · Cited by 324 · see citing works
Characterization of the human immune cell network at the gingival barrier
Dutzan, N., Konkel, J. E., Greenwell-Wild, T., & Moutsopoulos, N. M. (2016) · Mucosal Immunology · doi:10.1038/mi.2015.136 · Cited by 305 · see citing works
Self-citationMoutsopoulos, N. M., Konkel, J. E., Sarmadi, M., Eskan, M. A., Greenwell‐Wild, T., Dutzan, N., Abusleme, L., Zenobia, C., Hosur, K. B., Abe, T., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007696 · Cited by 303 · see citing works
Self-citationLoss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases
Liu, X., Lee, Y. S., Yu, C., & Egwuagu, C. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6070 · Cited by 290 · see citing works
Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C. Y., Wu, C., Baloglu, E., Schmidt, D. R., Ramesh, R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.004 · Cited by 277 · see citing works
Hajishengallis, G., & Lamont, R. J. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.010 · Cited by 275 · see citing works
Self-citationEvidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease
Cardoso, C. R. D. B., Garlet, G. P., Crippa, G. E., Rosa, A. L., Júnior, W. M., Rossi, M. A., & Silva, J. S. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00463.x · Cited by 270 · see citing works
Kantarcı, A., Oyaizu, K., & Dyke, T. E. V. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.1.66 · Cited by 268 · see citing works
Dutzan, N., Abusleme, L., Bridgeman, H., Greenwell-Wild, T., Zangerle-Murray, T., Fife, M. E., Bouladoux, N., Linley, H., Brenchley, L., Wemyss, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.010 · Cited by 252 · see citing works
Self-citationWithers, D. R., Hepworth, M. R., Wang, X., Mackley, E. C., Halford, E. E., Dutton, E. E., Marriott, C. L., Brucklacher-Waldert, V., Veldhoen, M., Kelsen, J. R., et al. (2016) · Nature Medicine · doi:10.1038/nm.4046 · Cited by 244 · see citing works
Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
Santori, F. R., Huang, P., van de Pavert, S. A., Douglass, E. F., Leaver, D. J., Haubrich, B. A., Keber, R., Lorbek, G., Konijn, T., Rosales, B. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.004 · Cited by 239 · see citing works
Position Paper: Systemic Antibiotics in Periodontics
Slots, J. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.11.1553 · Cited by 215 · see citing works
Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis
Moutsopoulos, N. M., Kling, H. M., Angelov, N., Jin, W., Palmer, R. J., Jr., Nares, S., Osorio, M., & Wahl, S. M. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.03.003 · Cited by 210 · see citing works
Self-citationVerma, A. H., Richardson, J., Zhou, C., Coleman, B. M., Moyes, D., Ho, J., Huppler, A., Ramani, K., McGeachy, M., Mufazalov, I., et al. (2017) · Science immunology · doi:10.1126/sciimmunol.aam8834 · Cited by 203 · see citing works
Glowacki, A. J., Yoshizawa, S., Jhunjhunwala, S., Vieira, A. E., Garlet, G. P., Sfeir, C. S., & Little, S. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302829110 · Cited by 199 · see citing works
IL ‐17: overview and role in oral immunity and microbiome
Abusleme, L., & Moutsopoulos, N. M. (2016) · Oral Diseases · doi:10.1111/odi.12598 · Cited by 185 · see citing works
Self-citationNeutrophil Hyper-responsiveness in Periodontitis
Matthews, J. B., Wright, H. J., Roberts, A., Ling‐Mountford, N., Cooper, P. R., & Chapple, I. (2007) · Journal of Dental Research · doi:10.1177/154405910708600806 · Cited by 183 · see citing works
The Involvement of IL-23 and the Th17 Pathway in Periodontitis
Ohyama, H., Kato‐Kogoe, N., Kuhara, A., Nishimura, F., Nakasho, K., Yamanegi, K., Yamada, N., Hata, M., Yamane, J., & Terada, N. (2009) · Journal of Dental Research · doi:10.1177/0022034509339889 · Cited by 182 · see citing works
Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1
Moutsopoulos, N. M., Zerbe, C. S., Greenwell‐Wild, T., Dutzan, N., Brenchley, L., DiPasquale, G., Uzel, G., Axelrod, K. C., Lisco, A., Notarangelo, L. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612197 · Cited by 176 · see citing works
Self-citationSmall molecule inhibitors of ROR γt: Targeting T h17 cells and other applications
Huh, J. R., & Littman, D. R. (2012) · European Journal of Immunology · doi:10.1002/eji.201242740 · Cited by 174 · see citing works
Subgingival Microbiome Shifts and Community Dynamics in Periodontal Diseases
Diaz, P. I., Hoare, A., & Hong, B. (2016) · Journal of the California Dental Association · doi:10.1080/19424396.2016.12221035 · Cited by 152 · see citing works
Self-citationImmune and regulatory functions of neutrophils in inflammatory bone loss
Hajishengallis, G., Moutsopoulos, N. M., Hajishengallis, E., & Chavakis, T. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.002 · Cited by 146 · see citing works
Self-citationAl‐Mossawi, H., Chen, L., Fang, H., Ridley, A., de Wit, J., Yager, N., Hammitzsch, A., Pulyakhina, I., Fairfax, B. P., Simone, D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01771-2 · Cited by 138 · see citing works
Position Paper Periodontal Maintenance
Cohen, R. E. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.9.1395 · Cited by 127 · see citing works
Comprehensive Periodontal Therapy: A Statement by the American Academy of Periodontology
(2011) · Journal of Periodontology · doi:10.1902/jop.2011.117001 · Cited by 101 · see citing works
Allam, J., Duan, Y., Heinemann, F., Winter, J., Götz, W., Deschner, J., Wenghoefer, M., Bieber, T. R. M., Jepsen, S. V., & Novak, N. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01752.x · Cited by 94 · see citing works
Mendelian Genetics of Human Susceptibility to Fungal InfectionPreprint
Lionakis, M. S., Netea, M. G., & Holland, S. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019638 · Cited by 87 · see citing works
Self-citationInhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity
Guo, Y., MacIsaac, K. D., Chen, Y., Miller, R. J., JAIN, R. K., Joyce-Shaikh, B., Ferguson, H. M., Wang, I., Cristescu, R., Mudgett, J. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.073 · Cited by 58 · see citing works
Oral Microbiome Characterization in Murine Models
Abusleme, L., Hong, B.-Y., Hoare, A., Konkel, J. E., Diaz, P., & Moutsopoulos, N. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2655 · Cited by 58 · see citing works
Self-citationNares, S., Moutsopoulos, N. M., Angelov, N., Rangel, Z. G., Munson, P. J., Sinha, N., & Wahl, S. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080677 · Cited by 36 · see citing works
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Flagged first, then by citations
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871 · see citing works
Self-citationOsteoimmunology: evolving concepts in bone–immune interactions in health and disease
Tsukasaki, M., & Takayanagi, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0178-8 · Cited by 789 · see citing works
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
The role of the microbiota in periodontal disease
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020) · Periodontology 2000 · doi:10.1111/prd.12296 · Cited by 698 · see citing works
Self-citationThe cytokine network involved in the host immune response to periodontitis
Pan, W., Wang, Q., & Chen, Q. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0064-z · Cited by 709 · see citing works
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
Kitamoto, S., Nagao‐Kitamoto, H., Jiao, Y., Gillilland, M. G., Hayashi, A., Imai, J., Sugihara, K., Miyoshi, M., Brazil, J. C., Kuffa, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.048 · Cited by 685 · see citing works
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity
Williams, D. W., Greenwell‐Wild, T., Brenchley, L., Dutzan, N., Overmiller, A. M., Sawaya, A. P., Webb, S., Martı́n, D., Hajishengallis, G., Divaris, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.013 · Cited by 523 · see citing works
Self-citationCurrent understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 533 · see citing works
Self-citationHost–microbiota interactions in immune-mediated diseases
Ruff, W. E., Greiling, T. M., & Kriegel, M. A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0367-2 · Cited by 489 · see citing works
The Nexus Between Periodontal Inflammation and Dysbiosis
Dyke, T. E. V., Bartold, P. M., & Reynolds, E. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00511 · Cited by 465 · see citing works
Microbial signatures of health, gingivitis and periodontitis
Abusleme, L., Hoare, A., Hong, B., & Diaz, P. I. (2021) · Periodontology 2000 · doi:10.1111/prd.12362 · Cited by 400 · see citing works
Self-citationValm, A. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.016 · Cited by 425 · see citing works
Periodontal Disease: The Good, The Bad, and The Unknown
Sedghi, L. M., Bacino, M. S., & Kapila, Y. L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.766944 · Cited by 385 · see citing works
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities
Li, X., Wang, H., Yu, X., Saha, G., Kalafati, L., Ioannidis, C., Mitroulis, I., Netea, M. G., Chavakis, T., & Hajishengallis, G. (2022) · Cell · doi:10.1016/j.cell.2022.03.043 · Cited by 337 · see citing works
Self-citationA guide to complement biology, pathology and therapeutic opportunity
Mastellos, D. C., Hajishengallis, G., & Lambris, J. D. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00926-1 · Cited by 343 · see citing works
Self-citationShen, Z., Kuang, S., Zhang, Y., Yang, M., Qin, W., Shi, X., & Lin, Z. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.07.002 · Cited by 295 · see citing works
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Sun, X., Gao, J., Meng, X. L., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 297 · see citing works
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 302 · see citing works
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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Silva, L. M., Doyle, A. D., Greenwell‐Wild, T., Dutzan, N., Tran, C. L., Abusleme, L., Juang, L. J., Leung, J., Chun, E. M., Lum, A. G., et al. (2021) · Science · doi:10.1126/science.abl5450 · Cited by 191 · see citing works
Self-citationKim, T. S., Silva, L. M., Theofilou, V. I., Greenwell‐Wild, T., Li, L., Williams, D. W., Ikeuchi, T., Brenchley, L., Core, N. G. A. C. B., Bugge, T. H., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221751 · Cited by 181 · see citing works
Self-citationMaintaining homeostatic control of periodontal bone tissue
Hathaway‐Schrader, J. D., & Novince, C. M. (2021) · Periodontology 2000 · doi:10.1111/prd.12368 · Cited by 171 · see citing works
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
Break, T. J., Oikonomou, V., Dutzan, N., Desai, J. V., Swidergall, M., Freiwald, T., Chauss, D., Harrison, O. J., Alejo, J., Williams, D. W., et al. (2021) · Science · doi:10.1126/science.aay5731 · Cited by 175 · see citing works
Self-citationInflammatory Networks Linking Oral Microbiome with Systemic Health and Disease
Kleinstein, S. E., Nelson, K. E., & Freire, M. (2020) · Journal of Dental Research · doi:10.1177/0022034520926126 · Cited by 170 · see citing works
Frailty, aging, and periodontal disease: Basic biologic considerations
Clark, D. L., Kotronia, E., & Ramsay, S. E. (2021) · Periodontology 2000 · doi:10.1111/prd.12380 · Cited by 159 · see citing works
Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
Huang, H., Pan, W., Wang, Y., Kim, H. S., Shao, D., Huang, B., Ho, T., Lao, Y., Quek, C. H., Shi, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33492-6 · Cited by 153 · see citing works
Drummond, R. A., Desai, J. V., Ricotta, E. E., Swamydas, M., Deming, C., Conlan, S., Quinones, M., Matei-Rascu, V., Sheriff, L., Lecky, D., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.013 · Cited by 141 · see citing works
Self-citationCalvo, S. S.-C., Bharath, L. P., Pugh, G. H., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B., & Nikolajczyk, B. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00575-1 · Cited by 141 · see citing works
Distal Consequences of Oral Inflammation
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01403 · Cited by 142 · see citing works
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
Pussinen, P. J., Kopra, E., Pietiäinen, M., Lehto, M. J., Zarić, S., Paju, S., & Salminen, A. (2022) · Periodontology 2000 · doi:10.1111/prd.12433 · Cited by 138 · see citing works
Mucosal immunology of the ocular surface
de Paiva, C. S., Leger, A. J. S., & Caspi, R. R. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00551-6 · Cited by 141 · see citing works
T and B Cells in Periodontal Disease: New Functions in A Complex Scenario
Figueredo, C. M., Lira-Junior, R., & Love, R. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163949 · Cited by 132 · see citing works
RANKL and osteoimmunology in periodontitis
Tsukasaki, M. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01165-3 · Cited by 127 · see citing works
Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment
Yan, N. J., Xu, J., Liu, G., Ma, C., Bao, L., Cong, Y., Wang, Z., Zhao, Y., Xu, W., & Chen, C. (2022) · ACS Nano · doi:10.1021/acsnano.2c05923 · Cited by 123 · see citing works
Suárez, L. J., Garzon, H. S., Arboleda, S., & Rodríguez, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591255 · Cited by 122 · see citing works
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
Wang, H., Divaris, K., Pan, B., Li, X., Lim, J., Saha, G., Barovic, M., Giannakou, D., Korostoff, J. M., Bing, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.003 · Cited by 118 · see citing works
Self-citationExploring the oral-gut linkage: Interrelationship between oral and systemic diseases
Yamazaki, K., & Kamada, N. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.11.006 · Cited by 117 · see citing works
Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1795362 · Cited by 116 · see citing works
Covid‐19 and oral diseases: Crosstalk, synergy or association?
Brandini, D. A., Takamiya, A. S., Thakkar, P., Schaller, S. J., Rahat, R., & Naqvi, A. R. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2226 · Cited by 115 · see citing works
Álvarez, C., Monasterio, G., Cavalla, F., Córdova, L. A., Hernández, M., Heymann, D., Garlet, G. P., Sorsa, T. A., Pärnänen, P., Lee, H., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01664 · Cited by 111 · see citing works
Trained immunity in chronic inflammatory diseases and cancer
Hajishengallis, G., Netea, M. G., & Chavakis, T. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01132-x · Cited by 111 · see citing works
Self-citationPeriodontal inflammation: Integrating genes and dysbiosis
Zhang, S., Yu, N., & Arce, R. M. (2019) · Periodontology 2000 · doi:10.1111/prd.12267 · Cited by 101 · see citing works
Complement-Dependent Mechanisms and Interventions in Periodontal Disease
Hajishengallis, G., Kajikawa, T., Hajishengallis, E., Maekawa, T., Reis, E. S., Mastellos, D. C., Yancopoulou, D., Hastürk, H., & Lambris, J. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00406 · Cited by 95 · see citing works
Self-citationPeriodontitis and Hypertension: Is the Association Causal?
Pinto, R. D., Pietropaoli, D., Aguilera, E. M., D’Aiuto, F., Cześnikiewicz‐Guzik, M., Monaco, A., Guzik, T. J., & Ferri, C. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00392-z · Cited by 98 · see citing works
Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms
Zhang, Z., Deng, M., Hao, M., & Tang, J. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0421-750r · Cited by 72 · see citing works
DEL-1-Regulated Immune Plasticity and Inflammatory Disorders
Hajishengallis, G., & Chavakis, T. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.010 · Cited by 90 · see citing works
Self-citationIL-10 Dampens an IL-17–Mediated Periodontitis-Associated Inflammatory Network
Sun, L., Girnary, M. S., Wang, L.-F., Jiao, Y., Zeng, E., Mercer, K., Zhang, J., Marchesan, J., Yu, N., Moss, K., et al. (2020) · Journal of Immunology · doi:10.4049/jimmunol.1900532 · Cited by 73 · see citing works
Prinz, I., Sandrock, I., & Mrowietz, U. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191397 · Cited by 89 · see citing works
Impact of systemic factors in shaping the periodontal microbiome
Teles, F., Wang, Y., Hajishengallis, G., Hastürk, H., & Marchesan, J. T. (2020) · Periodontology 2000 · doi:10.1111/prd.12356 · Cited by 89 · see citing works
Self-citationPhase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation
Hastürk, H., Hajishengallis, G., Lambris, J. D., Mastellos, D. C., & Yancopoulou, D. (2021) · Journal of Clinical Investigation · doi:10.1172/jci152973 · Cited by 88 · see citing works
Self-citationAn update on periodontal inflammation and bone loss
Zhang, M., Liu, Y., Afzali, H., & Graves, D. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385436 · Cited by 93 · see citing works
Periodontal connection with intestinal inflammation: Microbiological and immunological mechanisms
Kitamoto, S., & Kamada, N. (2022) · Periodontology 2000 · doi:10.1111/prd.12424 · Cited by 86 · see citing works
Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease
Cugini, C., Ramasubbu, N., Tsiagbe, V. K., & Fine, D. H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.617485 · Cited by 86 · see citing works
Möller, B., Kollert, F., Sculean, A., & Villiger, P. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01108 · Cited by 82 · see citing works
Fischer, F., Romero, R., Hellhund, A., Linne, U., Bertrams, W., Pinkenburg, O., Eldin, H. S., Binder, K., Jacob, R., Walker, A., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1829962 · Cited by 80 · see citing works
Porphyromonas Gingivalis in the Development of Periodontitis: Impact on Dysbiosis and Inflammation.
Benahmed, A. G., Mujawdiya, P. K., Noor, S., & Gasmi, A. (2022) · PubMed Central · doi:10.22092/ari.2021.356596.1875 · Cited by 78 · see citing works
Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis
Álvarez, C., Suliman, S., Almarhoumi, R., Vega, M. E., Rojas, C., Monasterio, G., Galindo, M. A., Vernal, R., & Kantarcı, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-76038-w · Cited by 77 · see citing works
Th17 Cells in Periodontitis and Its Regulation by A20
Huang, N., Dong, H., Luo, Y., & Shao, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742925 · Cited by 78 · see citing works
Skin Immunity to Dermatophytes: From Experimental Infection Models to Human Disease
Burstein, V. L., Beccacece, I., Guasconi, L., Mena, C. J., Cervi, L., & Chiapello, L. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.605644 · Cited by 78 · see citing works
Impact of gut microbiota on gut‐distal autoimmunity: a focus on T cells
Sprouse, M. L., Bates, N. A., Felix, K. M., & Wu, H.-J. J. (2018) · Immunology · doi:10.1111/imm.13037 · Cited by 75 · see citing works
Anticandidal Activities by Lactobacillus Species: An Update on Mechanisms of Action
Vázquez-Muñoz, R., & Dongari‐Bagtzoglou, A. I. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.689382 · Cited by 71 · see citing works
Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research
Li, Y., Cui, J., Liu, Y., Chen, K., Huang, L., & Liu, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.730203 · Cited by 70 · see citing works
The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis
Deng, J., Lu, C., Zhao, Q., Chen, K., Ma, S., & Li, Z. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12958 · Cited by 71 · see citing works
Uriarte, S. M., & Hajishengallis, G. (2022) · Immunological Reviews · doi:10.1111/imr.13152 · Cited by 71 · see citing works
Self-citationThe neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
Ando, Y., Tsukasaki, M., Huynh, N. C., Zang, S., Yan, M., Muro, R., Nakamura, K., Komagamine, M., Komatsu, N., Okamoto, K., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-023-00275-8 · Cited by 73 · see citing works
Pan, S., Lan, Y., Yang, Y., Zhang, Y., Yu, S., Wang, T., Zhu, Y., Yang, S., Yuan, X., Gao, X. Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c05266 · Cited by 71 · see citing works
Oral Versus Gastrointestinal Mucosal Immune Niches in Homeostasis and Allostasis
Suárez, L. J., Arboleda, S., Angelov, N., & Arce, R. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705206 · Cited by 71 · see citing works
The oral microbiome in autoimmune diseases: friend or foe?
Huang, X., Huang, X., Huang, Y., Zheng, J., Ye, L., Mai, Z., Zhao, X., Cui, L., & Huang, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03995-x · Cited by 74 · see citing works
de Molon, R. S., Vernal, R., Oliveira, G. E., Steffens, J. P., Ervolino, E., Theodoro, L. H., van den Beucken, J. J. J. P., & Tetradis, S. (2026) · Bone Research · doi:10.1038/s41413-025-00478-1 · Cited by 83 · see citing works
Wang, C., Hao, Y., Gianfilippo, R. D., Sugai, J. V., Li, J., Gong, W., Kornman, K. S., Wang, H., Kamada, N., Xie, Y., et al. (2021) · Theranostics · doi:10.7150/thno.57775 · Cited by 67 · see citing works
Interleukin-17 induces pyroptosis in osteoblasts through the NLRP3 inflammasome pathway in vitro
Lei, L., Sun, J., Han, J., Jiang, X., Wang, Z., & Chen, L. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107781 · Cited by 67 · see citing works
Differential immune cell infiltrations between healthy periodontal and chronic periodontitis tissues
Li, W., Zhang, Z., & Wang, Z. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01287-0 · Cited by 66 · see citing works
Surma, S., Romańczyk, M., Witalińska-Łabuzek, J., Czerniuk, M. R., Łabuzek, K., & Filipiak, K. J. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01140-x · Cited by 70 · see citing works
Elsayed, R., Elashiry, M., Liu, Y., El-Awady, A., Hamrick, M., & Cutler, C. W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.669989 · Cited by 64 · see citing works
Pietropaoli, D., Pinto, R. D., Ferri, C., Marzo, G., Giannoni, M., Ortu, E., & Monaco, A. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13216 · Cited by 63 · see citing works
Oral Mucositis: An Update on Innate Immunity and New Interventional Targets
Chen, C., Zhang, Q., Yu, W., Chang, B., & Le, A. D. (2020) · Journal of Dental Research · doi:10.1177/0022034520925421 · Cited by 68 · see citing works
Specific inhibition of IL‐6 receptor attenuates inflammatory bone loss in experimental periodontitis
Vieira, G. H. A., Rivas, A. C. A., Costa, K., Oliveira, L. F. F., Suzuki, K. T., Messora, M. R., Ricoldi, M. S. T., Almeida, A. L. G., & Taba, M. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0455 · Cited by 63 · see citing works
Rojas, C., García, M. P., Polanco, A., González, L., Sierra‐Cristancho, A., Melgar-Rodríguez, S. A., Cafferata, E. A., & Vernal, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.663328 · Cited by 63 · see citing works
Hajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 67 · see citing works
Self-citationThe Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases
Irwandi, R. A., Chiesa, S. T., Hajishengallis, G., Papayannopoulos, V., Deanfield, J. E., & D’Aiuto, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915081 · Cited by 65 · see citing works
Self-citationRajendran, M., Looney, S. W., Singh, N., Elashiry, M., Meghil, M. M., El‐Awady, A., Tawfik, O. K., Susin, C., Arce, R. M., & Cutler, C. W. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900046 · Cited by 63 · see citing works
Tongue Coating Bacteria as a Potential Stable Biomarker for Gastric Cancer Independent of Lifestyle
Xu, S., Xiang, C., Wu, J., Teng, Y., Wu, Z., Wang, R., Lu, B., Zhan, Z., Wu, H., & Zhang, J. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06637-0 · Cited by 61 · see citing works
Nagao, J.-I., Kishikawa, S., Tanaka, H., Toyonaga, K., Narita, Y., Yasumatsu, K., Tasaki, S., Arita-Morioka, K.-I., Nakayama, J., & Tanaka, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111314 · Cited by 60 · see citing works
Guided Bone Regeneration Using Barrier Membrane in Dental Applications
Kim, K., Su, Y., Kucine, A. J., Cheng, K., & Zhu, D. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00690 · Cited by 61 · see citing works
Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
Bellone, M., Brevi, A., & Huber, S. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-19 · Cited by 59 · see citing works
Yuh, D., Maekawa, T., Li, X., Kajikawa, T., Bdeir, K. H., Chavakis, T., & Hajishengallis, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013024 · Cited by 58 · see citing works
Self-citationActive gingival inflammation is linked to hypertension
Pietropaoli, D., Monaco, A., D’Aiuto, F., Muñoz Aguilera, E., Ortu, E., Giannoni, M., Czesnikiewicz-Guzik, M., Guzik, T. J., Ferri, C., & Del Pinto, R. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002514 · Cited by 56 · see citing works
T Helper 17 Cells as Pathogenic Drivers of Periodontitis
Dutzan, N., & Abusleme, L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-28524-1_9 · Cited by 58 · see citing works
Self-citationTan, J., Dai, A., Pan, L., Zhang, L., Wang, Z., Ke, T., Sun, W., Wu, Y., Ding, P., & Chen, L. (2021) · Journal of Immunology Research · doi:10.1155/2021/9919024 · Cited by 56 · see citing works
RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis
Yuan, G., Fu, C., Yang, S. T., Yuh, D.-Y., Hajishengallis, G., & Yang, S. (2021) · Journal of Dental Research · doi:10.1177/00220345211045303 · Cited by 57 · see citing works
Self-citationEpithelial-derived interleukin-23 promotes oral mucosal immunopathology
Kim, T. S., Ikeuchi, T., Theofilou, V. I., Williams, D. W., Greenwell‐Wild, T., June, A., Adade, E. E., Li, L., Abusleme, L., Dutzan, N., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.020 · Cited by 55 · see citing works
Self-citationElashiry, M., Elsayed, R., & Cutler, C. W. (2021) · Cells · doi:10.3390/cells11010115 · Cited by 55 · see citing works
Osteoimmunology in Periodontitis: Local Proteins and Compounds to Alleviate Periodontitis
Sirisereephap, K., Maekawa, T., Tamura, H., Hiyoshi, T., Domon, H., Isono, T., Terao, Y., Maeda, T., & Tabeta, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105540 · Cited by 56 · see citing works
Álvarez, C., Abdalla, H. B., Suliman, S., Rojas, P., Wu, Y., Almarhoumi, R., Huang, R., Galindo, M. A., Vernal, R., & Kantarcı, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664756 · Cited by 53 · see citing works
- Authors
- Dutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., Morell, R. J., Freeman, A. F., Lazarevic, V., Trinchieri, G., Diaz, P. I., Holland, S. M., Belkaid, Y., Hajishengallis, G., & Moutsopoulos, N. M.
- Affiliations
- Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
- University of Pennsylvania (US)
- National Institutes of Health (US)
- Genomics and Computational Biology Core, NIDCD, NIH, Bethesda, MD 20892, USA.
- UConn Health (US)
- Corresponding author
- Moutsopoulos, Niki M.
- ORCID
- Dutzan, Nicolas
- Kajikawa, Tetsuhiro
- Abusleme, Loreto
- Zuazo, Carlos E.
- Ikeuchi, Tomoko
- Brenchley, Laurie
- Abe, Toshiharu
- Hurabielle, Charlotte
- Martin, Daniel
- Morell, Robert J.
- Freeman, Alexandra F.
- Lazarevic, Vanja
- Trinchieri, Giorgio
- Diaz, Patricia I.
- Holland, Steven M.
- Belkaid, Yasmine
- Hajishengallis, George
- Moutsopoulos, Niki M.
- Venue
- Science Translational Medicine
- Published
- 2018-10-17
- Volume
- 10
- Issue
- 463
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6330016
- OpenAlex
- W2896857921
- Cited by
- 382
- References
- 58
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 49 · 2023: 46 · 2022: 47 · 2021: 70 · 2020: 57 · 2019: 28 · 2018: 1
- FWCI
- 44.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fondation pour la Recherche Médicale
- NIAID (IRP)
- NIDCR (Intramural, DE024153, DE026152)
- NCI Intramural
- La Roche-Posay
- CEDEF
- Philippe Foundation
- fondation groupe pasteur mutualité
- Société Française de Dermatologie
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- dysbiosis, oral microbiota, Th17 cells, oral inflammation, periodontitis, oral immunity, targeted therapy
- MeSH terms
- Animals, Bacteria, Bone Resorption, Cell Differentiation, Humans, Inflammation, Mouth Mucosa, Neutrophils, Periodontitis, Interleukin-6, Mice, Interleukin-23, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota, Dysbiosis
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