Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS

Melin, Karin; Skarphedinsson, Gudmundur; Thomsen, Per Hove; Weidle, Bernhard; Torp, Nor Christian; Valderhaug, Robert; Højgaard, Davíð R.M.A.; Hybel, Katja A.; Nissen, Judith Becker; Jensen, Sanne; Dahl, Kitty; Skärsäter, Ingela; Haugland, Bente Storm; Ivarsson, Tord

doi:10.1016/j.jaac.2019.01.010

Cited by 65Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS

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Melin, Karin, Skarphedinsson, Gudmundur, Thomsen, Per Hove, Weidle, Bernhard, Torp, Nor Christian, Valderhaug, Robert, Højgaard, Davíð R.M.A., Hybel, Katja A. +6 more·2020·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1016/j.jaac.2019.01.010

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Abstract

Objective This study evaluated the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigated whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of 3-year outcomes.Method This study is a part of the Nordic Long-term OCD Treatment Study (NordLOTS), in which 269 children and adolescents were treated with CBT. Nonresponders to CBT were randomized to extended treatment with continued CBT or pharmacotherapy with sertraline. Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores no higher than 15 and no higher than 10 were defined as treatment response and remission, respectively. Participants were assessed 2 and 3 years after first-step CBT. Linear mixed-effects models were used to analyze the outcomes.Results Intent-to-treat analyses showed a significant decrease in CY-BOCS total score from baseline (24.6) to 3-year follow-up (5.0; p = .001), with a mean decrease of 5.9 from after treatment to 3-year follow-up. Three years after treatment, 90% (n = 242) of participants were rated as responders and 73% were in clinical remission. The duration of treatment did not influence the symptom level at 3-year follow-up (p = .998) and no significant difference was found (p = .169) between the extended treatment conditions.Conclusion The results suggest that evidence-based treatment for pediatric OCD has long-term positive effects, whether a first step of manual-based CBT or extended treatment with CBT or sertraline. The improvements were maintained, and the symptoms decreased further during follow-up and were, after 3 years, similarly independent of treatment duration and form of extended treatment.Clinical trial registration information Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.

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Experiential avoidance is linked to emotional distress.
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From Coping strategies, anxiety and depression in ocd and schizophrenia: Changes during covid-19 (2021) · cites this paper as [18]
The Treatment and Procedures passage describes exposure-based CBT for pediatric OCD, and the Discussion passages report OCD symptom outcomes. Neither addresses a link between experiential avoidance and emotional distress. Searches for that phrase and for an association between avoidance and psychological distress found no supporting passage in our copy. (LLM, conf=0.76)
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Things that make you go Hmm: Myths and misconceptions within cognitive-behavioral treatment of obsessive-compulsive disorder
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A comparative, single-blind, randomized study on quetiapine and aripiperazole augmentation in treatment of selective serotonin reuptake inhibitor refractory obsessive-compulsive disorder
Talaeı, A., Hosseini, F. F., Aghili, Z., Akhondzadeh, S., Asadpour, E., Mehramiz, N. J., & Forouzanfar, F. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0381 · Cited by 14 · see citing works
Zwangsstörungen bei Kindern und Jugendlichen
Simons, M. (2023) · Die Psychotherapie · doi:10.1007/s00278-023-00657-7 · Cited by 13 · see citing works
Long-term outcomes of therapist-guided Internet-delivered cognitive behavior therapy for pediatric obsessive-compulsive disorder
Lenhard, F., Andersson, E., Mataix‐Cols, D., Rück, C., Aspvall, K., & Serlachius, E. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-00327-x · Cited by 12 · see citing works
Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder: 2021 Update
Noppen, B. L. V., Sassano-Higgins, S. A., Appasani, R. K., & Sapp, F. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20210015 · Cited by 12 · see citing works
Intensive treatments for children and adolescents with anxiety or obsessive-compulsive disorders: A systematic review and meta-analysis
Ganzevoort, C. O. W., Wolters, L. H., Hornstra, R., Grieve, C. M., Højgaard, D. R. M. A., Skarphedinsson, G. A., Weidle, B., Waite, P., Bertie, L.-A., Tomlinson, M., et al. (2024) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2024.102940 · Cited by 11 · see citing works
Long-term outcomes of a course of deep TMS for treatment-resistant OCD
Harmelech, T., Tendler, A., Arikan, M. K., Çetin, H. L., Esmeray, M. T., Ilhan, R., Vidrine, R., Muir, O., MacMillan, C., Sinclair, R., et al. (2022) · Brain Stimulation · doi:10.1016/j.brs.2021.12.011 · Cited by 10 · see citing works
“All sites were provided with a list of their patients who met response criteria at their last Y-BOCS evaluation following the Deep TMS treatment course (overall N ¼ 108) and were compensated for contacting these patients and reporting whether each of them had, since the end of their treatment, any medication change/CB…”
BackgroundInfluential
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) 2025 international guidelines for the management of patients with obsessive-compulsive disorder
Ameringen, M. V., Fineberg, N. A., Ravindran, A. V., Arnold, P. D., Beaulieu, S., Brakoulias, V., Brietzke, E. M., Dowlati, Y., Drummond, L. M., Ferretti, C. J., et al. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.12.039 · Cited by 10 · see citing works
What is the impact of pharmacotherapy on psychotherapy for obsessive-compulsive disorder?
Marazziti, D., Pozza, A., Avella, M. T., & Mucci, F. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1775814 · Cited by 9 · see citing works
Efficacy of group cognitive-behavioral therapy in adolescents with obsessive compulsive disorder: a systematic review and meta-analysis
Bortoncello, C. F., Cardoso, N. D. O., Salvador, E. Z., de Avila, R. C., Machado, W. D. L., & Ferrão, Y. A. (2022) · Brazilian Journal of Psychiatry · doi:10.47626/1516-4446-2021-2264 · Cited by 8 · see citing works
Stepped Care Internet-Delivered vs Face-to-Face Cognitive-Behavior Therapy for Pediatric Obsessive-Compulsive Disorder
Aspvall, K., Andersson, E., Lenhard, F., Melin, K., Norlin, L., Wallin, L., Silverberg-Mörse, M., Feldman, I., Bottai, M., Mataix‐Cols, D., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.13810 · Cited by 8 · see citing works
Current Research Updates on PANDAS and PANS
Franklin, M. E., Eken, S. C., & Osterlund, E. (2023) · Current Developmental Disorders Reports · doi:10.1007/s40474-023-00280-w · Cited by 7 · see citing works
eCBT Versus Standard Individual CBT for Paediatric Obsessive–Compulsive Disorder
Babiano-Espinosa, L., Skarphéðinsson, G., Weidle, B., Wolters, L. H., Compton, S. N., Ivarsson, T., & Skokauskas, N. (2022) · Child Psychiatry & Human Development · doi:10.1007/s10578-022-01350-7 · Cited by 7 · see citing works
“NordLOTS documented that the treatment gains were durable over a follow-up period of 3 years [23].”
Background
Online CBT Versus Standard CBT for Pediatric Obsessive-Compulsive Disorder
Weidle, B., Babiano-Espinosa, L., Skokauskas, N., Wolters, L. H., Henriksen, M., Arntzen, J., Skare, A., Ivarsson, T., Groff, T., & Skarphéðinsson, G. (2024) · Child Psychiatry & Human Development · doi:10.1007/s10578-024-01745-8 · Cited by 6 · see citing works
“Nord - LOTS has documented that the treatment gains were durable over a follow-up period of 3 years [32].”
Therapist guided, parent-led cognitive behavioural therapy (CBT) for pre-adolescent children with obsessive compulsive disorder (OCD): a non-concurrent multiple baseline case series
Chessell, C., Halldorsson, B., Walters, S., Farrington, A., Harvey, K., & Creswell, C. (2023) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465823000450 · Cited by 5 · see citing works
“…CY-BOCS is considered the ‘ gold standard ’ assessment for OCD in young people (Lewin and Piacentini, 2010) and is routinely used in OCD treatment trials (e.g. Bolton et al ., 2011; Farrell et al ., 2022; Melin et al ., 2020) and was therefore selected as the primary outcome measure for this study.”
Method
Long-term effectiveness and cost-effectiveness of guided internet-based cognitive behavioral therapy for obsessive-compulsive disorder: 24-month follow-up
Matsumoto, K., Hamatani, S., & Shimizu, E. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100725 · Cited by 5 · see citing works
“Previous studies examining long-term outcomes through ≥ 12-month follow-ups have not observed such delayed treatment effects in face-to-face ERP (H ø jgaard et al., 2017; Melin et al., 2020; Matsumoto et al., 2020).”
Background
A General Factor of Psychopathology Predicts Treatment and Long-Term Outcomes in Children and Adolescents With Obsessive-Compulsive Disorder
Cervin, M., Højgaard, D. R. M. A., Jensen, S. S., Torp, N. C., Skarphéðinsson, G., Nissen, J. B., Melin, K., Borrelli, D. F., Hybel, K. A., Thomsen, P. H., et al. (2024) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2024.06.003 · Cited by 4 · see citing works
Challenges Related to the Implementation of Measurement-Based Care for the Treatment of Major Depressive Disorder: A Feasibility Study
Tavakoli, E., Xiang, A., Husain, M. I., Blumberger, D. M., Kloiber, S. M., Müller, D. J., Ortiz, A., Perivolaris, A., & Mulsant, B. H. (2025) · Pharmacopsychiatry · doi:10.1055/a-2508-5757 · Cited by 4 · see citing works
Overcoming barriers in cognitive-behavioral therapy for youth anxiety and obsessive-compulsive disorder: Addressing parent behaviors
Chiappini, E. A., Parrish, C., Reynolds, E. K., & Mcguire, J. F. (2021) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2021.85.3.231 · Cited by 4 · see citing works
Long-term effect of stepped-care vs in-person cognitive behavioral therapy for pediatric obsessive-compulsive disorder
Lauri, K. O., Andersson, E., Mataix‐Cols, D., Norlin, L., Eriksson, V., Melin, K., Lenhard, F., Serlachius, E., & Aspvall, K. (2023) · Internet Interventions · doi:10.1016/j.invent.2023.100613 · Cited by 4 · see citing works
Neurochemical properties measured by 1H magnetic resonance spectroscopy may predict cognitive behaviour therapy outcome in paediatric OCD: a pilot study
Ivarsson, T., Melin, K., Carlsson, Å., Ljungberg, M., Forssell-Aronsson, E. B., Starck, G., & Skarphéðinsson, G. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02407-y · Cited by 4 · see citing works
Editorial: Cognitive-Behavioral Therapy Versus Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder
Strayhorn, J. M. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.03.015 · Cited by 4 · see citing works
Psychotic vulnerability in pediatric obsessive-compulsive disorder: associations with clinical features and treatment outcome in two clinical samples
Borrelli, D. F., Højgaard, D. R. M. A., Storch, E. A., GELLER, D. A., Melin, K., Thomsen, P. H., Ivarsson, T., Weidle, B., Torp, N. C., Tonna, M., et al. (2025) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-025-02757-y · Cited by 2 · see citing works
“The NordLOTS sample has been described in detail elsewhere [31–33].”
Long- term remission status in pediatric obsessive-compulsive disorder: Evaluating the predictive value of symptom severity after treatment
Jensen, S. S., Mortensen, E. L., Skarphéðinsson, G., Højgaard, D. R. M. A., Hybel, K. A., Nissen, J. B., Ivarsson, T., Weidle, B., Torp, N. C., & Thomsen, P. H. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114906 · Cited by 2 · see citing works
“Intent-to-treat analyses showed that 73% of the sample were considered remitters three years after Step 1 according to a CY-BOCS score of ≤ 10 (Melin et al., 2020).”
Method
Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2022) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-022-00537-z · Cited by 2 · see citing works
“Several recent studies demonstrated the effect of extended treatments beyond a treatment length of 7 weeks [31] and 14 weeks [32] and on long-term stability [33].”
Background
Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD
Duholm, C. S., Jensen, S. S., Rask, C. U., Thomsen, P. H., Ivarsson, T., Skarphéðinsson, G., Torp, N. C., Weidle, B., Nissen, J. B., & Højgaard, D. R. M. A. (2022) · Child Psychiatry & Human Development · doi:10.1007/s10578-022-01480-y · Cited by 1 · see citing works
“If the patient reported deterioration of symptoms, 10 CBT sessions alto-gether (including the booster sessions) were offered [17].”
Standard individual cognitive-behavioral therapy for children and adolescents with pediatric obsessive-compulsive disorder
Skarphéðinsson, G., Højgaard, D. R. M. A., Hybel, K. A., Thomsen, P. H., & Ivarsson, T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85757-4.00023-7 · Cited by 1 · see citing works
Long-term functional impairment in pediatric OCD after and during treatment: An analysis of distinct trajectories
Smárason, O., Højgaard, D. R. M. A., Jensen, S. S., Storch, E. A., Arnkelsson, G. B., Wolters, L. H., Torp, N. C., Melin, K., Weidle, B., Nissen, J. B., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115223 · Cited by 1 · see citing works
CAMALEO TOC: Construction of a manual for the treatment of adolescents with obsessive compulsive disorder
Bortoncello, C. F., Cardoso, N. D. O., & Ferrão, Y. A. (2023) · Revista Brasileira de Terapias Cognitivas · doi:10.5935/1808-5687.20230021 · Cited by 1 · see citing works
“It is recommended that adolescents receive a diagnosis and appropriate treatment as early as possible (Melin et al., 2020).”
Background
Psychopharmacology for Pediatric OCD and Related Disorders
Greenberg, E., Johnson, G., & GELLER, D. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-57472-6_10 · Cited by 1 · see citing works
Long-term outcomes of therapist-guided Internet-delivered cognitive behavior therapy for pediatric obsessive-compulsive disorder: A naturalistic one-year follow-upPreprint
Lenhard, F., Andersson, E., Mataix‐Cols, D., Rück, C., Aspvall, K., & Serlachius, E. (2020) · doi:10.31234/osf.io/3nk2s · Cited by 1 · see citing works
Current Pharmacological Treatments for Childhood Onset OCD
Franklin, M. E., Eken, S. C., Karan, S. G. T., & Riemann, B. C. (2019) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-019-00196-6
Pediatric Obsessive-Compulsive Disorder
Guzick, A. G., Schneider, S. C., & Storch, E. A. (2020) · Comprehensive Clinical Psychology · doi:10.1016/b978-0-12-818697-8.00028-5
Transmission of shame? The psychoanalytic treatment of a child with OCD
Hannula, M.-L. (2024) · The Scandinavian Psychoanalytic Review · doi:10.1080/01062301.2025.2457237
“…outcomes of the treatment for paediatric OCD, 269 children and adolescents were treated with CBT and sertraline, and the results seem to be even more promising: Three years after treatment, up to 90% of participants were rated as responders and 73% were in clinical remission (Melin et al., 2020).”
Obsessive-Compulsive Disorder in Childhood and Adolescence
Højgaard, D. R. M. A., & Skarphéðinsson, G. (2025) · Springer eBooks · doi:10.1007/978-3-031-40858-8_200-1
Zwangsstörungen im Kindes- und Jugendalter
Walitza, S., Smigielski, L., Ball, J., Brezinka, V., & Rütter, C. (2025) · KJP up2date · doi:10.1055/a-2583-0677
The role of treatment expectations in predicting treatment outcomes: examining clinical and demographic influences
Torp, N. C., Højgaard, D. R. M. A., Aalberg, M., Hybel, K. A., Skarphéðinsson, G., Thomsen, P. H., Ivarsson, T., Weidle, B., Nissen, J. B., Melin, K., et al. (2025) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2025.2528075
“Exposure-based CBT (EB-CBT) has proven highly effective for pediatric OCD [7], demonstrating sustained efficacy in both short-term [8,9] and long-term studies [10,11].”
Additional file 5 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552785
Additional file 9 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552797
Additional file 8 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552794
Additional file 1 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552773
Additional file 6 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552788
Additional file 7 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552791
Additional file 3 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552779
Additional file 4 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552782
Additional file 2 of Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
Adam, J., Goletz, H., Dengs, S., Klingenberger, N., Könnecke, S., Vonderbank, C., Hautmann, C., Hellmich, M., Plück, J., & Döpfner, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552776
Comparative study for managing OCD and anxiety symptoms (COSMOS) study: Rationale, design, and methods
Zhou, J. X., Onyeka, O. “., Carter, J. A., Myers, A. M., Garcia, A., Contreras-Muñoz, J., Messerli, M. C., Dang, B. D., Vieira, A., Ahmed, A., et al. (2026) · Contemporary Clinical Trials · doi:10.1016/j.cct.2026.108286
Three-Year Follow-Up of children and adolescents with OCD Who Did Not Respond to Initial Cognitive-Behavioral Therapy (CBT): Outcomes of Continued CBT vs. Sertraline
Skarphéðinsson, G., Weidle, B., Torp, N. C., Højgaard, D. R. M. A., Jensen, S., Melin, K., Hybel, K. A., Thomsen, P. H., Nissen, J. B., & Ivarsson, T. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03009-3
“At the end of the three-year follow-up period, 90% of patients were classified as responders, and 73% reached clinical remission [20].”
Evidence So Far on Psychoeducation
Strayhorn, J. M., Chai, K. Y. Y., & Zhang‐James, Y. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-92-0922-4_8
CBT and pharmacotherapy after nonresponse for anxiety and obsessive-compulsive disorders in youth: a systematic review and meta-analysis
Ganzevoort, C. O. W., Hornstra, R., Wolters, L. H., Isaksen, C. S., Smárason, O., Hybel, K. A., Højgaard, D. R. M. A., Skarphéðinsson, G., Kreuze, L. J., & Nauta, M. H. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03192-3

Three-Year Outcome for Responders and Non-Responders of Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Melin, K., Skarphéðinsson, G., Thomsen, P. H., Weidle, B., Torp, N. C., Højgaard, D. R. M. A., Hybel, K. A., Nissen, J. B., Jensen, S. S., & Ivarsson, T. (2023)
Cognitive Behavior Treatment for Child and Adolescent Obsessive-Compulsive Disorder (OCD): One Year Treatment Responder Outcomes from the Nordic Long-term OCD Treatment Study (NordLOTS)
Højgaard, D. R. M. A., Hybel, K. A., Ivarsson, T., Skarphéðinsson, G., Nissen, J. B., Weidle, B., Melin, K., Torp, N. C., Valderhaug, R., Dahl, K., et al. (2017)
The Nordic Long-Term OCD Treatment Study (NordLOTS):Treatment Outcomes and One-year Follow-up of Initial Cognitive Behavioral Therapy Responders
Højgaard, D. R. M. A., Torp, N. C., Skarphéðinsson, G., Ivarsson, T., Dahl, K., Melin, K., Nissen, J. B., Hybel, K. A., Valderhaug, R., Weidle, B., et al. (2018)
Three-Year Follow-Up of children and adolescents with OCD Who Did Not Respond to Initial Cognitive-Behavioral Therapy (CBT): Outcomes of Continued CBT vs. Sertraline
Skarphéðinsson, G., Weidle, B., Torp, N. C., Højgaard, D. R. M. A., Jensen, S., Melin, K., Hybel, K. A., Thomsen, P. H., Nissen, J. B., & Ivarsson, T. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03009-3
Long-term outcomes of obsessive-compulsive disorder in children and adolescents
Melin, K. (2019) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1 · see citing works

Authors: Melin, K., Skarphedinsson, G., Thomsen, P. H., Weidle, B., Torp, N. C., Valderhaug, R., Højgaard, D. R. M. A., Hybel, K. A., Nissen, J. B., Jensen, S., Dahl, K., Skärsäter, I., Haugland, B. S., & Ivarsson, T.
Affiliations: University of Gothenburg (SE)
Aarhus University Hospital (DK)
Norwegian University of Science and Technology (NO)
Vestre Viken Hospital Trust (NO)
Center for Child and Adolescent Mental Health, Eastern and Southern Norway (NO)
Halmstad University (SE)
Uni Research (Norway) (NO)
Corresponding author: Melin, Karin
ORCID: Melin, Karin
Thomsen, Per Hove
Weidle, Bernhard
Torp, Nor Christian
Højgaard, Davíð R.M.A.
Hybel, Katja A.
Nissen, Judith Becker
Jensen, Sanne
Skärsäter, Ingela
Haugland, Bente Storm
Ivarsson, Tord
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2020-02
Volume: 59
Issue: 2
Pages: 244-253
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1016/j.jaac.2019.01.010
OpenAlex: W2914065342
Cited by: 65
References: 48
Citations by year: 2026: 5 · 2025: 5 · 2024: 17 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 5
FWCI: 7.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Stiftelsen Clas Groschinskys Minnesfond
TrygFonden
Lundbeck Foundation
Danish Council for Strategic Research
Norwegian Research Council
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: pediatric obsessive-compulsive disorder, stepped care, cognitive behavioral therapy, sertraline, long-term outcomes, treatment response, clinical remission, extended treatment, treatment duration, symptom maintenance, children and adolescents
MeSH terms: Adolescent, Child, Follow-Up Studies, Humans, Obsessive-Compulsive Disorder, Cognitive Behavioral Therapy, Treatment Outcome, Sertraline

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Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS

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