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Cited by 386Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

The Brown Longitudinal Obsessive Compulsive Study: Clinical Features and Symptoms of the Sample at Intake

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Pinto, Anthony, Mancebo, Maria C., Eisen, Jane L., Pagano, Maria E., Rasmussen, Steve A.·2006·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v67n0503PMC PMC3272757
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Abstract

OBJECTIVE: This article describes the method and intake findings of the Brown Longitudinal Obsessive Compulsive Study, the first comprehensive prospective investigation of the naturalistic course of obsessive-compulsive disorder (OCD) in a large clinical sample using longitudinal research methodology. METHOD: Intake data, collected between June 2001 and October 2004, are presented for 293 adult participants in a prospective, naturalistic study of OCD. Participants had a primary diagnosis of DSM-IV OCD and had sought treatment for the disorder. RESULTS: Our findings indicate that OCD typically has a gradual onset and a continuous course regardless of age at onset. There is a substantial lag between the onset of the disorder and initiation of treatment. OCD, which almost always coexists with other psychiatric symptoms, leads to serious social and occupational impairment. Compared with participants with late-onset OCD, early-onset participants had higher rates of lifetime panic disorder, eating disorders, and obsessive-compulsive personality disorder. The groups also differed on the types of obsessive-compulsive symptoms that were first noticed, as well as on rates of current obsessions and compulsions. CONCLUSION: The demographics, clinical characteristics, comorbidity rates, and symptom presentation of the sample are consistent with those reported for cross-sectional studies of OCD, including the DSM-IV Field Trial. The current sample has a number of advantages over previously collected prospective samples of OCD in that it is large, diagnostically well characterized, recruited from multiple settings, and treatment seeking. This unique data set will contribute to the identification of meaningful phenotypes in OCD based on stability of symptom dimensions, prospective course patterns, and treatment response.

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  • There is a substantial average gap of up to 17 years between symptom onset and receipt of treatment, together with high rates of disengagement from efficacious treatments such as psychological therapy.

    “There is a substantial average gap of up to 17 years between symptom onset and receipt of treatment [10, 11], together with high rates of disengagement from efficacious treatments such as psychological therapy [12].”

    From Testing the psychometric properties of the illness perceptions questionnaire for OCD (IPQ-O) (2019) · cites this paper as [11]

    The Results report a substantial treatment delay in this OCD sample, but say participants first received treatment more than 17 years after initially experiencing symptoms, rather than up to 17 years later. The disengagement claim is attached to citation [12], not to this source. (LLM, conf=0.86)

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Research works printed but not linked: 5

  1. [1]Murray CJ, Lopez AD. The Global Burden of Disease. Boston, Mass: Harvard University Press; 1996. [Google Scholar]
  2. [16]First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-I/P, version 2.0) New York, NY: Biometrics Research, New York State Psychiatric Institute; 1996. [Google Scholar]
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  5. [25]American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4. Washington, DC: American Psychiatric Association; 2000. Text Revision. [Google Scholar]

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Authors
Pinto, A., Mancebo, M. C., Eisen, J. L., Pagano, M. E., & Rasmussen, S. A.
Affiliations
  • Butler Hospital (US)
  • Brown University (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2006-05-15
Volume
67
Issue
05
Pages
703-711
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v67n0503
PMC
PMC3272757
OpenAlex
W2135721147
Cited by
386
References
45
Citations by year
2026: 15 · 2025: 21 · 2024: 19 · 2023: 17 · 2022: 29 · 2021: 41 · 2020: 21 · 2019: 25 · 2018: 16 · 2017: 23 · 2016: 18 · 2015: 19 · 2014: 17 · 2013: 25 · 2012: 12
FWCI
14.37
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH060218)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
obsessive-compulsive disorder, age of onset, treatment-seeking delay, comorbidities, panic disorder, eating disorders, obsessive-compulsive personality disorder, obsessions and compulsions, presenting symptoms
MeSH terms
Adult, Mental Disorders, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Obsessive-Compulsive Disorder, Patient Acceptance of Health Care, Personality Inventory, Prospective Studies, Psychiatric Status Rating Scales, Severity of Illness Index, Comorbidity, Age of Onset, Age Distribution, Diagnostic and Statistical Manual of Mental Disorders

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