CoChat
Sign Up
Cited by 133Skin Protection and AgingNonmelanoma Skin Cancer StudiesDermatology and Skin Diseases

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Broad-spectrum sunscreens provide better protection from solar ultraviolet-simulated radiation and natural sunlight-induced immunosuppression in human beings

Moyal, Dominique D., Fourtanier, Anny M.·2008·Journal of the American Academy of Dermatology
DOI 10.1016/j.jaad.2007.04.035
Open this paper in CoChat — free account

Abstract

Background It is well established that ultraviolet (UV) radiation induces immunomodulatory effects that may be involved in skin cancer. Recent studies have shown that UVA (320-400 nm) and UVB (290-320 nm) radiation are immunosuppressive. As a result, sunscreens, which mainly absorb UVB, may be less effective in preventing UV radiation-induced immunosuppression than broad-spectrum products. Objective We sought to study the effects of UVA exposure on human delayed-type hypersensitivity (DTH) response and compare the efficacy of sunscreens having different levels of sun-protection factor (SPF) and UVA protection against both solar-simulated radiation and outdoor real-life sunlight exposure conditions. Methods DTH was assessed using a kit which includes 7 recall antigens that most of the participants encountered during childhood immunization. Evaluation of DTH test response was made 48 hours after test application before and after UV exposure with or without sunscreens. Results In unprotected participants, the response to DTH tests was significantly reduced irrespective of UV types of exposure (full-spectrum UVA, long UVA, solar-simulated radiation). A UVB sunscreen failed to protect from solar-simulated radiation-induced immunosuppression. In contrast, a broad-spectrum sunscreen with the same SPF but providing a high protection in the UVA range significantly reduced local UV-induced immunosuppression and prevented the distant effects. In the outdoor study, as compared with DTH responses obtained before sun exposure, no alteration of immune response was detected when the skin was protected by a broad-spectrum sunscreen having a high protection level in the UVA (SPF 25, UVA protection factor 14). Conversely a broad-spectrum sunscreen with lower protection against UVA (SPF 25, UVA protection factor 6) failed to prevent UV-impaired response. Limitations These results have been obtained after repeated exposure. Additional experiments obtained under acute exposure are in progress. Conclusion These findings clearly demonstrated the role of UVA in the induction of photoimmunosuppression together with the need for sunscreen products providing efficient photoprotection throughout the entire UV spectrum.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jaad.2007.04.035

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Ullrich, 1999, Sunscreens and immunesuppression: is there a need for UVA protection?, Photochem Photobiol, 69, 74S
  2. Damian, 1999, Measurement of in vivo sunscreen immune protection factors in humans, Photochem Photobiol, 70, 910, 10.1111/j.1751-1097.1999.tb08301.x · DOI

Cited by

Sorted by citations

See all 133

Related

See all

Metadata

Authors
Moyal, D. D., & Fourtanier, A. M.
Affiliations
L'Oréal (France) (FR)
Corresponding author
Moyal, Dominique D.
ORCID
Fourtanier, Anny M.
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2008-05
Volume
58
Issue
5
Pages
S149-S154
ISSN
0190-9622 (ISSN-L)
DOI
10.1016/j.jaad.2007.04.035
OpenAlex
W1973106980
Cited by
133
References
20
Citations by year
2026: 5 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 11 · 2012: 6
FWCI
12.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the American Academy of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
broad-spectrum sunscreen, UVA protection, UV-induced immunosuppression, delayed-type hypersensitivity, simulated solar radiation, sun protection factor, UVA protection factor, skin cancer prevention, photoprotection
MeSH terms
Absorption, Adolescent, Adult, Female, Humans, Hypersensitivity, Delayed, Immune Tolerance, Male, Radiation Dosage, Skin, Skin Neoplasms, Sunlight, Sunscreening Agents, Ultraviolet Rays

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review