Dietary glycemic index and glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels in patients with acne
Abstract
Background Several isolated observations have suggested that acne can develop in groups when a high glycemic index diet is adopted. Objective This study was designed to examine associations among daily diet glycemic index, glycemic loads, serum insulin levels, and acne. Methods A total of 49 patients with acne and 42 healthy control subjects were included in the study. At the initial visit, fasting glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels were measured. A voluntary self-completed questionnaire was administered and participants were asked how frequently they consumed the specified amount of food. Overall glycemic index and dietary glycemic load were calculated. Results No significant differences were observed between patients with acne and control subjects in serum glucose, insulin, leptin levels, overall glycemic index, or dietary glycemic load. Limitations The information and data obtained from this questionnaire were limited to patients' own recollections. Conclusion Results of this study indicate that dietary glycemic index, glycemic load, and insulin levels do not have a role in pathogenesis of acne in younger patients.
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17.9% (5/28) of observational studies exclusively assessed the association between GI/glycemic load and acne.
“Overall, 17.9% (5/28) of the observational studies exclusively assessed the association between GI/glycemic load and acne (Table I).19, 20, 21, 22, 23”
From Diet and acne: A systematic review (2022) · cites this paper as [19]
In a study of Kitavans and Aché, no cases of acne were found among adolescents or adults after many months of observation.
“After many months of observation, the researchers found no cases of acne among adolescents or adults.19”
From Diet and acne: A systematic review (2022) · cites this paper as [19]
Cites
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The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism
Wallach, E. E., Barbieri, R. L., Smith, S., & Ryan, K. J. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60060-2 · Cited by 348 · see citing works
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Kwon, H., Yoon, J., Hong, J., Jung, J., Park, M., & Suh, D. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1346 · Cited by 157 · see citing works
Diet and acne: A systematic review
Meixiong, J., Ricco, C., Vasavda, C., & Ho, B. K. (2022) · JAAD International · doi:10.1016/j.jdin.2022.02.012 · Cited by 108 · see citing works
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The impact of diet on common skin disorders
Rezakovic, S., Pavlic, M., Navratil, M., Pocanic, L., Žužul, K., & Kostovic, K. (2014) · Journal of Nutritional Therapeutics · doi:10.6000/1929-5634.2014.03.03.6 · Cited by 4 · see citing works
- Authors
- Kaymak, Y., Adisen, E., Ilter, N., Bideci, A., Gurler, D., & Celik, B.
- Affiliations
- Gazi University (TR)
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 57
- Issue
- 5
- Pages
- 819-823
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2141286374
- Cited by
- 113
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 6
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- acne, dietary glycemic index, glycemic load, insulin, insulin-like growth factor I, insulin-like growth factor binding protein-3, leptin, serum glucose, acne pathogenesis, diet
- MeSH terms
- Acne Vulgaris, Adult, Blood Glucose, Diet, Female, Humans, Insulin, Insulin-Like Growth Factor I, Male, Surveys and Questionnaires, Insulin-Like Growth Factor Binding Protein 3, Leptin, Glycemic Index
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