Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study
Abstract
Background Bimatoprost 0.03% is associated with increased growth and prominence of eyelashes. Objective We sought to compare the safety and efficacy of once-daily bimatoprost 0.03% versus vehicle in increasing eyelash length, thickness, and darkness after topical administration to upper eyelid margins. Methods In this 5-month study, subjects were randomized to receive once-daily bimatoprost 0.03% (n = 137) or vehicle (n = 141). The primary end point was eyelash prominence assessed by the investigator global eyelash assessment scale. Secondary efficacy measures included eyelash length, thickness, and darkness measured by digital image analysis and patient-reported outcomes. Safety data included adverse event monitoring and ophthalmic examinations. Results A higher percentage of subjects treated with bimatoprost 0.03% (78.1%) versus vehicle (18.4%) demonstrated at least a 1-grade increase in global eyelash assessment score at week 16 (P < .0001). Subjects in the bimatoprost 0.03% group also had statistically significantly greater increases in eyelash length, thickness, and darkness (P < .0001) than those in the vehicle group. For adverse events, only conjunctival hyperemia occurred at a statistically significant higher incidence rate in the bimatoprost 0.03% versus the vehicle group (P = .03). Limitations Short-term duration of the trial was a limitation; black subjects were not enrolled secondary to technical requirements of digital image analysis. Conclusion Bimatoprost 0.03% was found to be effective at enhancing eyelashes in adults with a very good safety profile.
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Bimatoprost 0.03% has enhanced eyelash prominence in clinical trials enrolling mostly Caucasian subjects.
“Bimatoprost 0.03 % has enhanced eyelash prominence in clinical trials enrolling mostly Caucasian subjects.”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
In both the Japanese study and the North American cohort, GEA score improvements were significantly correlated with greater patient-reported satisfaction with eyelashes.
“Moreover, in both populations, the GEA score improvements were significantly correlated with greater patient-reported satisfaction with eyelashes, as measured with ESQ-9 in the current study and with the original 23-item ESQ in the North American study [15].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
In both the Japanese study 1 and the North American cohort, improvement in eyelash prominence was maintained at the post-treatment assessment at month 5.
“In both populations, the improvement in eyelash prominence was maintained at the post-treatment assessment at month 5.”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
The types of adverse events reported in the current trials were consistent with those of prior studies investigating mostly Caucasian populations with hypotrichosis of the eyelashes.
“The types of AEs reported in the current trials were consistent with those of prior studies investigating mostly Caucasian populations with hypotrichosis of the eyelashes [15, 17].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
The rate of conjunctival hyperemia reported at biomicroscopy was consistent with that previously reported in a mostly Caucasian cohort from a prior study.
“The rate of conjunctival hyperemia reported at biomicroscopy was consistent with that previously reported in a mostly Caucasian cohort from a prior study [15].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
Both the GEA and the GEA-J scales have been validated in previous clinical studies.
“Both the GEA and the GEA-J scales have been validated in previous clinical studies [15].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
In the North American study, statistically significant between-group differences in intraocular pressure were reported from week 1 through week 16, and by week 20 these differences had resolved.
“Statistically significant between-group differences in IOP were reported in the North American study from week 1 through week 16. By the week 20 visit, these differences had resolved [15].”
From Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies (2014) · cites this paper as [15]
Cites
The number needed to treat: a clinically useful measure of treatment effect
Cook, R. J., & Sackett, D. L. (1995) · BMJ · doi:10.1136/bmj.310.6977.452 · Cited by 1,885 · see citing works
Brandt, J. D., VanDenburgh, A. M., Chen, K., & Whitcup, S. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(01)00584-x · Cited by 152 · see citing works
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Bimatoprost for Eyelash Growth in Japanese Subjects: Two Multicenter Controlled Studies
Harii, K., Arase, S., Tsuboi, R., Weng, E., Daniels, S., & VanDenburgh, A. (2014) · Aesthetic Plastic Surgery · doi:10.1007/s00266-014-0293-7 · Cited by 29 · see citing works
Self-citation
- Authors
- Smith, S., Fagien, S., Whitcup, S. M., Ledon, F., Somogyi, C., Weng, E., & Beddingfield, F. C.
- Affiliations
- Therapeutics Clinical Research (US)
- University of California, Los Angeles (US)
- Corresponding author
- Smith, Stacy
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 66
- Issue
- 5
- Pages
- 801-806
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2069794340
- Cited by
- 79
- References
- 2
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- bimatoprost, eyelash length, topical prostamide, conjunctival hyperemia, adverse events
- MeSH terms
- Bimatoprost, Administration, Topical, Adult, Aged, Amides, California, Cloprostenol, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Eyelashes, Female, Follow-Up Studies, Humans, Male, Middle Aged, Reference Values, Treatment Outcome, Risk Assessment, Cross-Over Studies, Young Adult, Drug-Related Side Effects and Adverse Reactions
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