Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults
Abstract
Background Genetic and environmental components may contribute to acne causation. Objective We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne. Methods We conducted a case-control study in dermatologic outpatient clinics in Italy. Cases (205) were consecutive those receiving a new diagnosis of moderate to severe acne. Control subjects (358) were people with no or mild acne, coming for a dermatologic consultation other than for acne. Results Moderate to severe acne was strongly associated with a family history of acne in first-degree relatives (odds ratio 3.41, 95% confidence interval 2.31-5.05). The risk was reduced in people with lower body mass index with a more pronounced effect in male compared with female individuals. No association with smoking emerged. The risk increased with increased milk consumption (odds ratio 1.78, 95% confidence interval 1.22-2.59) in those consuming more than 3 portions per week. The association was more marked for skim than for whole milk. Consumption of fish was associated with a protective effect (odds ratio 0.68, 95% confidence interval 0.47-0.99). No association emerged between menstrual variables and acne risk. Limitations Some degree of overmatching may arise from choosing dermatologic control subjects and from inclusion of mild acne in the control group. Conclusions Family history, body mass index, and diet may influence the risk of moder…
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35.7% (10/28) of observational studies exclusively commented on the association between dairy and acne.
“Overall, 35.7% (10/28) exclusively commented on the association between dairy and acne (Table II),24, 25, 26, 27, 28, 29, 30, 31, 32, 33”
From Diet and acne: A systematic review (2022) · cites this paper as [27]
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- Authors
- Di Landro, A., Cazzaniga, S., Parazzini, F., Ingordo, V., Cusano, F., Atzori, L., Cutrì, F. T., Musumeci, M. L., Zinetti, C., Pezzarossa, E., Bettoli, V., Caproni, M., Lo Scocco, G., Bonci, A., Bencini, P., & Naldi, L.
- Affiliations
- Centro Studi GISED (IT)
- University of Milan (IT)
- Azienda Ospedaliera G.Rummo (IT)
- University of Cagliari (IT)
- Federico II University Hospital (IT)
- University of Catania (IT)
- Istituti Ospitalieri di Cremona (IT)
- Arcispedale Sant'Anna (IT)
- Santa Maria Nuova Hospital (IT)
- Corresponding author
- Naldi, Luigi
- ORCID
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 67
- Issue
- 6
- Pages
- 1129-1135
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2123507773
- Cited by
- 255
- References
- 0
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 19 · 2023: 28 · 2022: 27 · 2021: 22 · 2020: 16 · 2019: 22 · 2018: 19 · 2017: 21 · 2016: 14 · 2015: 11 · 2014: 18 · 2013: 10 · 2012: 4
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- acne, moderate to severe acne, family history of acne, body mass index, dietary factors, milk consumption, skim milk, fish consumption, menstrual history, smoking, adolescents, young adults, genetic and environmental risk factors
- MeSH terms
- Acne Vulgaris, Adolescent, Diet, Female, Humans, Male, Menstruation, Risk Factors, Severity of Illness Index, Body Mass Index, Case-Control Studies, Young Adult
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