Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases
Open accessAbstract
Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.
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Omega-3 and omega-6 polyunsaturated fatty acids play an important role as human skin barriers, and also have certain effects in the prevention and treatment of skin inflammation.
“Omega-3 and omega-6 polyunsaturated fatty acids play an important role as human skin barriers, and also have certain effects in the prevention and treatment of skin inflammation [104].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [104]
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Bioactive Compounds for Skin Health: A Review
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- Authors
- Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z.
- Affiliations
- University Hospital Centre Zagreb (HR)
- Opća bolnica Dubrovnik (HR)
- University of Zagreb (HR)
- Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Šalata 4, 10 000 Zagreb, Croatia
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-01-23
- Volume
- 21
- Issue
- 3
- Pages
- 741
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7037798
- OpenAlex
- W3001152781
- Cited by
- 400
- References
- 177
- Citations by year
- 2026: 51 · 2025: 88 · 2024: 71 · 2023: 76 · 2022: 57 · 2021: 46 · 2020: 9 · 2019: 1
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- omega-3 polyunsaturated fatty acids, omega-6 fatty acids, inflammatory skin diseases, gamma-linolenic acid, long-chain polyunsaturated fatty acids, dietary supplementation, atopic dermatitis, psoriasis, acne, cell membrane lipid composition, gene expression, anti-inflammatory activity
- MeSH terms
- Acne Vulgaris, Dermatitis, Gene Expression Regulation, Humans, Psoriasis, Fatty Acids, Omega-3, gamma-Linolenic Acid, Fatty Acids, Omega-6, Toll-Like Receptors
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