Characterizing the young patient with aortic dissection: results from the international registry of aortic dissection (IRAD)
Open accessAbstract
Objectives The goal of this study was to better characterize the young patient with aortic dissection (AoD).Background Aortic dissection is unusual in young patients, and frequently associated with unusual presentations.Methods Data were collected on 951 patients diagnosed with AoD between January 1996 and November 2001. Two categories of patients, <40 years and >or=40 years, were compared using chi-square cross tabulations for categorical and Student t test for continuous data.Results Sixty-eight patients (7%) with AoD were <40 years of age. Compared with patients >or=40 years, younger patients were less likely to have a prior history of hypertension (p < 0.05); however, younger patients were more likely to have Marfan syndrome, bicuspid aortic valve, and prior aortic surgery (all, p < 0.05). Clinical presentations in the two age groups were similar; however, younger patients were less likely to be hypertensive (25% vs. 45%, p = 0.003). The proximal aortas of young AoD patients were larger (all, p < 0.05) compared with older patients. These differences in aortic size between age groups were not entirely related to Marfan syndrome. Mortality among young patients was similar to patients >or=40 years of age (22% vs. 24%, p = NS), irrespective of the site of dissection.Conclusions Compared with older patients with AoD, young patients have unique risk factors for dissection: Marfan syndrome, bicuspid aortic valves, and larger aortic dimensions. Surprisingly, the mortality risk for young AoD patients is not lower than older AoD patients.
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The risk of aortic dissections may be increased during the peripartum period in TS.
“The risk of aortic dissections may be increased during the peripartum period in TS.515-517”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [515]
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- Authors
- Januzzi, J. L., Isselbacher, E. M., Fattori, R., Cooper, J. V., Smith, D. E., Fang, J., Eagle, K. A., Mehta, R. H., Nienaber, C. A., & Pape, L. A.
- Affiliations
- Massachusetts General Hospital (US)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- University of Michigan (US)
- University of Rostock (DE)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Pape, Linda A
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 43
- Issue
- 4
- Pages
- 665-669
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2056941285
- Cited by
- 511
- References
- 17
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 23 · 2023: 21 · 2022: 14 · 2021: 35 · 2020: 23 · 2019: 36 · 2018: 26 · 2017: 29 · 2016: 26 · 2015: 28 · 2014: 27 · 2013: 22 · 2012: 25
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
- Keywords
- aortic dissection, young patients, age comparison, Marfan syndrome, bicuspid aortic valve, hypertension, aortic size, mortality, risk factors, clinical features
- MeSH terms
- Adult, Age Factors, Aortic Dissection, Aortic Valve, Female, Humans, Male, Marfan Syndrome, Middle Aged, Registries, Risk Factors, Case-Control Studies, Aortic Aneurysm, Thoracic
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